Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Stub1 STIP1 homology and U-Box containing protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 56424, updated on 22-Apr-2017
    Official Symbol
    Stub1provided by MGI
    Official Full Name
    STIP1 homology and U-Box containing protein 1provided by MGI
    Primary source
    MGI:MGI:1891731
    See related
    Ensembl:ENSMUSG00000039615
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Chip; AW046544; 0610033N24Rik; 2210017D18Rik; 2310040B03Rik
    Orthologs
    Location:
    17 A3.3; 17 12.93 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (25830636..25833361, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (25967581..25970306, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 16 Neighboring gene WD repeat domain 24 Neighboring gene jumonji domain containing 8 Neighboring gene microRNA 3082 Neighboring gene rhomboid, veinlet-like 1 (Drosophila) Neighboring gene ras homolog family member T2 Neighboring gene WD repeat domain 90

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp70 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Hsp70 protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp90 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    TPR domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    TPR domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    misfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging TAS
    Traceable Author Statement
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase activity involved in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    ubiquitin-ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to misfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to misfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum unfolded protein response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    misfolded or incompletely synthesized protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    misfolded or incompletely synthesized protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein folding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein maturation TAS
    Traceable Author Statement
    more info
    PubMed 
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination TAS
    Traceable Author Statement
    more info
    PubMed 
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glucocorticoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glucocorticoid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent SMAD protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin conjugating enzyme complex TAS
    Traceable Author Statement
    more info
    PubMed 
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    STIP1 homology and U box-containing protein 1
    Names
    E3 ubiquitin-protein ligase CHIP
    RING-type E3 ubiquitin transferase CHIP
    carboxy terminus of Hsp70-interacting protein
    NP_062693.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019719.3NP_062693.1  STIP1 homology and U box-containing protein 1

      See identical proteins and their annotated locations for NP_062693.1

      Status: PROVISIONAL

      Source sequence(s)
      AC159277
      Consensus CDS
      CCDS28533.1
      UniProtKB/Swiss-Prot
      Q9WUD1
      Related
      ENSMUSP00000040431.8, ENSMUST00000044911.8
      Conserved Domains (4) summary
      pfam04564
      Location:228300
      U-box; U-box domain
      sd00006
      Location:2755
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:6191
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:2691
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      25830636..25833361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center