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    Cd34 CD34 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12490, updated on 12-Sep-2017
    Official Symbol
    Cd34provided by MGI
    Official Full Name
    CD34 antigenprovided by MGI
    Primary source
    MGI:MGI:88329
    See related
    Ensembl:ENSMUSG00000016494 Vega:OTTMUSG00000050886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU040960
    Orthologs
    Location:
    1 H6; 1 98.38 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (194938821..194961292)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (196765015..196787486)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene microRNA 3962 Neighboring gene predicted gene, 39748 Neighboring gene predicted gene, 16897 Neighboring gene predicted gene, 39749 Neighboring gene predicted gene, 32250

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    sulfate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-2 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    paracrine signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glial cell-derived neurotrophic factor secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of granulocyte colony-stimulating factor production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of odontogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    tissue homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glomerular endothelium fenestra ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    hematopoietic progenitor cell antigen CD34
    Names
    cluster designation 34

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111059.1NP_001104529.1  hematopoietic progenitor cell antigen CD34 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001104529.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter protein (isoform 1).
      Source sequence(s)
      AK044121, AV319386, BY249301, BY327943
      Consensus CDS
      CCDS48490.1
      UniProtKB/TrEMBL
      Q543Y2
      Related
      ENSMUSP00000106439.2, OTTMUSP00000069340, ENSMUST00000110815.8, OTTMUST00000128965
      Conserved Domains (1) summary
      pfam06365
      Location:187325
      CD34_antigen; CD34/Podocalyxin family
    2. NM_133654.3NP_598415.1  hematopoietic progenitor cell antigen CD34 isoform 2 precursor

      See identical proteins and their annotated locations for NP_598415.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) has a longer C-terminus compared to isoform 1.
      Source sequence(s)
      AK044121, AK053874, AV319386, BU058977, BY249301, BY327943
      Consensus CDS
      CCDS15640.1
      UniProtKB/Swiss-Prot
      Q64314
      UniProtKB/TrEMBL
      Q543B6, Q543Y2
      Related
      ENSMUSP00000016638.2, OTTMUSP00000069339, ENSMUST00000016638.7, OTTMUST00000128964
      Conserved Domains (1) summary
      pfam06365
      Location:187381
      CD34_antigen; CD34/Podocalyxin family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      194938821..194961292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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