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    Pdgfa platelet derived growth factor, alpha [ Mus musculus (house mouse) ]

    Gene ID: 18590, updated on 23-May-2017
    Official Symbol
    Pdgfaprovided by MGI
    Official Full Name
    platelet derived growth factor, alphaprovided by MGI
    Primary source
    MGI:MGI:97527
    See related
    Ensembl:ENSMUSG00000025856 Vega:OTTMUSG00000025151
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    5 G2; 5 77.65 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (138976381..138997686, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (139452925..139470907, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31891 Neighboring gene predicted gene, 38726 Neighboring gene protein kinase, cAMP dependent regulatory, type I beta Neighboring gene dynein, axonemal assembly factor 5 Neighboring gene Sad1 and UNC84 domain containing 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    platelet-derived growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    animal organ morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    bone development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell projection assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    digestive tract development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    platelet-derived growth factor subunit A
    Names
    PDGF A-chain
    PDGF subunit A
    PDGF-1
    platelet-derived growth factor A-chain
    platelet-derived growth factor alpha polypeptide

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008808.3NP_032834.1  platelet-derived growth factor subunit A precursor

      See identical proteins and their annotated locations for NP_032834.1

      Status: PROVISIONAL

      Source sequence(s)
      AC117698
      Consensus CDS
      CCDS19802.1
      UniProtKB/Swiss-Prot
      P20033
      UniProtKB/TrEMBL
      Q99L56
      Related
      ENSMUSP00000075463.7, OTTMUSP00000030442, ENSMUST00000076095.13, OTTMUST00000061873
      Conserved Domains (2) summary
      smart00141
      Location:94181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:2195
      PDGF_N; Platelet-derived growth factor, N terminal region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      138976381..138997686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240971.2XP_011239273.1  platelet-derived growth factor subunit A isoform X1

      See identical proteins and their annotated locations for XP_011239273.1

      UniProtKB/TrEMBL
      G5E891
      Conserved Domains (2) summary
      smart00141
      Location:94181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:2195
      PDGF_N; Platelet-derived growth factor, N terminal region
    2. XM_006504659.3XP_006504722.1  platelet-derived growth factor subunit A isoform X1

      See identical proteins and their annotated locations for XP_006504722.1

      UniProtKB/TrEMBL
      G5E891
      Related
      ENSMUSP00000038870.6, OTTMUSP00000030453, ENSMUST00000046901.13, OTTMUST00000061887
      Conserved Domains (2) summary
      smart00141
      Location:94181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:2195
      PDGF_N; Platelet-derived growth factor, N terminal region
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