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    CDK2 cyclin dependent kinase 2 [ Homo sapiens (human) ]

    Gene ID: 1017, updated on 13-Aug-2017
    Official Symbol
    CDK2provided by HGNC
    Official Full Name
    cyclin dependent kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:1771
    See related
    Ensembl:ENSG00000123374 MIM:116953; Vega:OTTHUMG00000170575
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDKN2; p33(CDK2)
    Summary
    This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
    Orthologs
    Location:
    12q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (55966769..55972789)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56360556..56366573)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase alpha Neighboring gene premelanosome protein Neighboring gene RAB13, member RAS oncogene family pseudogene Neighboring gene RAB5B, member RAS oncogene family Neighboring gene sulfite oxidase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study.
    NHGRI GWA Catalog
    Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
    NHGRI GWA Catalog
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    NHGRI GWA Catalog
    Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat CDK2 regulates HIV-1 Tat-mediated transcription by phosphorylation of CDK9 at position Ser90 and decreases 7SK RNA levels PubMed
    tat Iron chelators 311 and ICL670 decrease cellular activity of CDK2 and reduce HIV-1 Tat phosphorylation by CDK2 PubMed
    tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed
    tat Amino acid residues serine 16 and 46 of HIV-1 Tat are phosphorylated by CDK2; mutation of these two residues reduces HIV-1 transcription in cells PubMed
    tat HIV-1 Tat 41/44 peptide TAALS from the core domain of Tat inhibits Tat-mediated HIV-1 gene expression and replication by binding the Cdk2/Cyclin E complex and inhibiting the phosphorylation of serine 5 of RNAPII PubMed
    tat Cdk2 phosphorylates HIV-1 Tat PubMed
    tat Cdk2/cyclin E stimulates Tat-dependent HIV-1 transcription PubMed
    tat Tat-mediated phosphorylation of RNA Polymerase C-terminal domain involves dynamic interactions of Cdk2 with Tat amino acids 15-24 and 36-49 and requires cysteine 22 in the activation domain of Tat and amino acids 42-72 of Tat PubMed
    tat HIV-1 Tat induces Cdk2 to phosphorylate the RNA Polymerase C-terminal domain PubMed
    tat Cdk2 activity is enhanced by HIV-1 Tat expression in Jurkat T cells and is associated with Tat-induced apoptosis PubMed
    tat HIV-1 Tat induces Cyclin E-associated cdk activity in lymphocytes, indicating Tat drives cells to the late G1 phase of the cell cycle PubMed
    tat HIV-1 Tat induces a G1 arrest in cells of glial origin, leading to a downregulation of cyclin E-Cdk2 kinase activity and phosphorylation of Rb PubMed

    Go to the HIV-1, Human Interaction Database

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    • Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
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    • Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
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    • DNA Damage Response, organism-specific biosystem (from WikiPathways)
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    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
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    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
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    • FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
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    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
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    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
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    • G0 and Early G1, organism-specific biosystem (from REACTOME)
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    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G1/S DNA Damage Checkpoints, organism-specific biosystem (from REACTOME)
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    • G1/S Transition, organism-specific biosystem (from REACTOME)
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    • G2 Phase, organism-specific biosystem (from REACTOME)
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    • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
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    • G2/M Transition, organism-specific biosystem (from REACTOME)
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    • Gene Expression, organism-specific biosystem (from REACTOME)
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    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
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    • Hemostasis, organism-specific biosystem (from REACTOME)
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    • Herpes simplex infection, organism-specific biosystem (from KEGG)
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    • Herpes simplex infection, conserved biosystem (from KEGG)
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    • Homology Directed Repair, organism-specific biosystem (from REACTOME)
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    • ID signaling pathway, organism-specific biosystem (from WikiPathways)
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    • Integrated Cancer Pathway, organism-specific biosystem (from WikiPathways)
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    • M/G1 Transition, organism-specific biosystem (from REACTOME)
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    • Measles, organism-specific biosystem (from KEGG)
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    • Meiosis, organism-specific biosystem (from REACTOME)
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    • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
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    • Oocyte meiosis, organism-specific biosystem (from KEGG)
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      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
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    • Processing of DNA double-strand break ends, organism-specific biosystem (from REACTOME)
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    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
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    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
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    • Prostate cancer, organism-specific biosystem (from KEGG)
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    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
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    • Regulation of DNA replication, organism-specific biosystem (from REACTOME)
      Regulation of DNA replication, organism-specific biosystemDNA replication is regulated at various levels via ORC proteins. This pathway includes annotation of individual events that lead to the regulation of replication.
    • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
    • Regulation of TP53 Activity through Phosphorylation, organism-specific biosystem (from REACTOME)
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    • Regulation of TP53 Degradation, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Degradation, organism-specific biosystemIn unstressed cells, TP53 (p53) has a short half-life as it undergoes rapid ubiquitination and proteasome-mediated degradation. The E3 ubiquitin ligase MDM2, which is a transcriptional target of TP53...
    • Regulation of TP53 Expression and Degradation, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Expression and Degradation, organism-specific biosystemTP53 (p53) tumor suppressor protein is a transcription factor that functions as a homotetramer (Jeffrey et al. 1995). The protein levels of TP53 are low in unstressed cells due to MDM2-mediated ubiqu...
    • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
      Regulation of mitotic cell cycle, organism-specific biosystem
      Regulation of mitotic cell cycle
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of retinoblastoma protein, organism-specific biosystem
      Regulation of retinoblastoma protein
    • Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
      Removal of licensing factors from origins, organism-specific biosystemLicensing factors are removed from the origin by various means like biochemical modification (phosphorylation) or by physical association with other proteins. This pathway includes the annotations of...
    • Retinoblastoma (RB) in Cancer, organism-specific biosystem (from WikiPathways)
      Retinoblastoma (RB) in Cancer, organism-specific biosystemDescribes the role of retinoblastoma (RB) gene in cancer.
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continues,...
    • SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystem (from REACTOME)
      SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystemDuring G1, the activity of cyclin-dependent kinases (CDKs) is kept in check by the CDK inhibitors (CKIs) p27 and p21, thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 20...
    • Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystem (from REACTOME)
      Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystemThe culture medium of senescent cells in enriched in secreted proteins when compared with the culture medium of quiescent i.e. presenescent cells and these secreted proteins constitute the so-called ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling Pathways in Glioblastoma, organism-specific biosystem (from WikiPathways)
      Signaling Pathways in Glioblastoma, organism-specific biosystemThe most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core p...
    • Signaling by PTK6, organism-specific biosystem (from REACTOME)
      Signaling by PTK6, organism-specific biosystemPTK6 (BRK) is an oncogenic non-receptor tyrosine kinase that functions downstream of ERBB2 (HER2) (Xiang et al. 2008, Peng et al. 2015) and other receptor tyrosine kinases, such as EGFR (Kamalati et ...
    • Signaling events mediated by PRL, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by PRL, organism-specific biosystem
      Signaling events mediated by PRL
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    • Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
      Switching of origins to a post-replicative state, organism-specific biosystem
      Switching of origins to a post-replicative state
    • Synthesis of DNA, organism-specific biosystem (from REACTOME)
      Synthesis of DNA, organism-specific biosystemThe actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of ...
    • TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystem (from REACTOME)
      TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystemUnder a variety of stress conditions, TP53 (p53), stabilized by stress-induced phosphorylation at least on S15 and S20 serine residues, can induce the transcription of genes involved in cell cycle ar...
    • TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest, organism-specific biosystem (from REACTOME)
      TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest, organism-specific biosystemThe most prominent TP53 target involved in G1 arrest is the inhibitor of cyclin-dependent kinases CDKN1A (p21). CDKN1A is one of the earliest genes induced by TP53 (El-Deiry et al. 1993). CDKN1A bind...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • miRNA Regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
      miRNA Regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...
    • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
      p53 pathway, organism-specific biosystem
      p53 pathway
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53-Dependent G1 DNA Damage Response, organism-specific biosystem (from REACTOME)
      p53-Dependent G1 DNA Damage Response, organism-specific biosystemMost of the damage-induced modifications of p53 are dependent on the ATM kinase. The first link between ATM and p53 was predicted based on the earlier studies that showed that AT cells exhibit a redu...
    • p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
      p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystemThe arrest at G1/S checkpoint is mediated by the action of a widely known tumor suppressor protein, p53. Loss of p53 functions, as a result of mutations in cancer prevent the G1/S checkpoint (Kuerbi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cyclin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    contributes_to histone kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase activity TAS
    Traceable Author Statement
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
    Traceable Author Statement
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication TAS
    Traceable Author Statement
    more info
    PubMed 
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    G2/M transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    Ras protein signal transduction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nitric oxide TAS
    Traceable Author Statement
    more info
    PubMed 
    centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    centrosome duplication TAS
    Traceable Author Statement
    more info
    PubMed 
    histone phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    meiotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    mitotic G1 DNA damage checkpoint TAS
    Traceable Author Statement
    more info
    PubMed 
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA-dependent DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of gene silencing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    response to organic substance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    X chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    Y chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome TAS
    Traceable Author Statement
    more info
    PubMed 
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    condensed chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin A1-CDK2 complex IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin A2-CDK2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin E1-CDK2 complex IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin E2-CDK2 complex IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cyclin-dependent kinase 2
    Names
    cdc2-related protein kinase
    cell division protein kinase 2
    p33 protein kinase
    NP_001277159.1
    NP_001789.2
    NP_439892.2
    XP_011536034.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034014.1 RefSeqGene

      Range
      5001..11021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001290230.1NP_001277159.1  cyclin-dependent kinase 2 isoform 3

      See identical proteins and their annotated locations for NP_001277159.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AA789250, AK293246, BC003065, DA814453
      Consensus CDS
      CCDS76567.1
      UniProtKB/Swiss-Prot
      P24941
      UniProtKB/TrEMBL
      B4DDL9, E7ESI2
      Related
      ENSP00000393605.2, OTTHUMP00000244050, ENST00000440311.6, OTTHUMT00000409654
      Conserved Domains (2) summary
      PLN00009
      Location:1229
      PLN00009; cyclin-dependent kinase A; Provisional
      cl21453
      Location:3226
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001798.4NP_001789.2  cyclin-dependent kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_001789.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA789250, AK291941, BC003065, DA814453
      Consensus CDS
      CCDS8898.1
      UniProtKB/Swiss-Prot
      P24941
      UniProtKB/TrEMBL
      A0A024RB77
      Related
      ENSP00000266970.4, OTTHUMP00000244047, ENST00000266970.8, OTTHUMT00000409650
      Conserved Domains (2) summary
      PLN00009
      Location:1289
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07860
      Location:3286
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
    3. NM_052827.3NP_439892.2  cyclin-dependent kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_439892.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as CDK2deltaT) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2, also known as d-HSCDK2) is shorter than isoform 1.
      Source sequence(s)
      AA789250, AB012305, BC003065, DA814453
      Consensus CDS
      CCDS8899.1
      UniProtKB/Swiss-Prot
      P24941
      UniProtKB/TrEMBL
      A0A024RB10
      Related
      ENSP00000243067.4, OTTHUMP00000244052, ENST00000354056.4, OTTHUMT00000409656
      Conserved Domains (2) summary
      PLN00009
      Location:1255
      PLN00009; cyclin-dependent kinase A; Provisional
      cl21453
      Location:3252
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      55966769..55972789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537732.1XP_011536034.1  cyclin-dependent kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_011536034.1

      UniProtKB/TrEMBL
      G3V5T9
      Related
      ENSP00000452514.1, OTTHUMP00000244049, ENST00000553376.5, OTTHUMT00000409653
      Conserved Domains (2) summary
      PLN00009
      Location:1337
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07860
      Location:3334
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      56327686..56333684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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