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    Rnf2 ring finger protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 19821, updated on 8-Apr-2018
    Official Symbol
    Rnf2provided by MGI
    Official Full Name
    ring finger protein 2provided by MGI
    Primary source
    MGI:MGI:1101759
    See related
    Ensembl:ENSMUSG00000026484 Vega:OTTMUSG00000049593
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dinG; Ring1B; AI326319; AI450156; AU019207
    Expression
    Broad expression in CNS E11.5 (RPKM 21.3), placenta adult (RPKM 21.2) and 25 other tissues See more
    Orthologs
    Location:
    1; 1 G1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (151469406..151500922, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (153316536..153347953, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene SWT1 RNA endoribonuclease homolog (S. cerevisiae) Neighboring gene tRNA methyltransferase 1 like Neighboring gene microRNA 7682 Neighboring gene predicted gene, 36527 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene Neighboring gene family with sequence similarity 129, member A

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RING-like zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H2A monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    histone H2A-K119 monoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone ubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    PRC1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    PcG protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    sex chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    E3 ubiquitin-protein ligase RING2
    Names
    RING finger protein 1B
    RING-type E3 ubiquitin transferase RING2
    NP_035407.1
    XP_006529332.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360844.1NP_001347773.1  E3 ubiquitin-protein ligase RING2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC115060, AC165946
      Conserved Domains (2) summary
      pfam16207
      Location:255339
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
      cd16740
      Location:56102
      RING-HC_RING2; RING finger, HC subclass, found in really interesting new gene 2 protein (RING2) and similar proteins
    2. NM_001360845.1NP_001347774.1  E3 ubiquitin-protein ligase RING2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AC115060, AC165946
      Conserved Domains (3) summary
      pfam16207
      Location:246330
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
      cd16531
      Location:5191
      RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
      cl26688
      Location:11103
      DWNN; DWNN domain
    3. NM_001360847.1NP_001347776.1  E3 ubiquitin-protein ligase RING2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AC115060, AC165946, AK030319
      Conserved Domains (3) summary
      pfam16207
      Location:246330
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
      cd16531
      Location:5191
      RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
      cl26688
      Location:11103
      DWNN; DWNN domain
    4. NM_011277.3NP_035407.1  E3 ubiquitin-protein ligase RING2 isoform b

      See identical proteins and their annotated locations for NP_035407.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AC115060, AC165946, AK012358
      Consensus CDS
      CCDS15362.1
      UniProtKB/Swiss-Prot
      Q9CQJ4
      Related
      ENSMUSP00000075476.4, OTTMUSP00000068351, ENSMUST00000076110.10
      Conserved Domains (3) summary
      pfam16207
      Location:246330
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
      cd16531
      Location:5191
      RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
      cl26688
      Location:11103
      DWNN; DWNN domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      151469406..151500922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529269.3XP_006529332.1  E3 ubiquitin-protein ligase RING2 isoform X1

      Conserved Domains (2) summary
      pfam16207
      Location:255339
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
      cd16740
      Location:56102
      RING-HC_RING2; RING finger, HC subclass, found in really interesting new gene 2 protein (RING2) and similar proteins
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