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    emrE DLP12 prophage; multidrug resistance protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948442, updated on 5-Sep-2017
    Gene symbol
    emrE
    Gene description
    DLP12 prophage; multidrug resistance protein
    Primary source
    EcoGene:EG10629
    Locus tag
    b0543
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
    Also known as
    eb; ECK0534; JW0531; mvrC
    Summary
    EmrE defunct PDB structures 1S7B and 2F2M, and any conclusions derived from these structures, have been retracted due to a software data inversion error (Ma, 2007; Chang, 2007). [More information is available at EcoGene: EG10629]. EmrE is a multidrug efflux protein with a broad substrate specificity. [More information is available at EcoCyc: EG10629].
    Sequence:
    NC_000913.3 (568315..568647)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene IS3 transposase A Neighboring gene IS3 transposase B Neighboring gene pseudo Neighboring gene DLP12 prophage; putative recombinase Neighboring gene inactive polymorphonuclear leukocyte migration suppressor; DLP12 prophage; UPF0098 family secreted protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    amino-acid betaine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    choline transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    drug:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to DNA damage stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    choline transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    drug export IEA
    Inferred from Electronic Annotation
    more info
     
    glycine betaine transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    xenobiotic metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    DLP12 prophage; multidrug resistance protein
    NP_415075.1
    • methylviologen resistance

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      568315..568647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415075.1 DLP12 prophage; multidrug resistance protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415075.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P23895
      Conserved Domains (1) summary
      PRK09541
      Location:1110
      emrE; multidrug efflux protein; Reviewed
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