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    CDC28 cyclin-dependent serine/threonine-protein kinase CDC28 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 852457, updated on 8-May-2017
    Gene symbol
    CDC28
    Gene description
    cyclin-dependent serine/threonine-protein kinase CDC28
    Primary source
    SGD:S000000364
    Locus tag
    YBR160W
    Gene type
    protein coding
    RNA name
    cyclin-dependent serine/threonine-protein kinase CDC28
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CDK1; HSL5; SRM5
    See CDC28 in Map Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (560078..560974)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Amn1p Neighboring gene ketoreductase Neighboring gene mannosylinositol phosphorylceramide synthase catalytic subunit CSH1 Neighboring gene Tos1p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II core binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    7-methylguanosine mRNA capping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    histone phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    meiotic DNA double-strand break processing IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitotic cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitotic sister chromatid biorientation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation of RNA polymerase II C-terminal domain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of meiotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nuclear cell cycle DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of nuclear cell cycle DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of spindle pole body separation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of spindle pole body separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of trehalose catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of trehalose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of triglyceride catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of triglyceride catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to nuclear periphery IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation involved in DNA double-strand break processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation involved in cellular protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein phosphorylation involved in cellular protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation involved in double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation involved in mitotic spindle assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein phosphorylation involved in protein localization to spindle microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of budding cell apical bud growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of budding cell apical bud growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of filamentous growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of nucleosome density IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of telomere maintenance via telomerase IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with astral microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular bud neck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with spindle pole body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Names
    cyclin-dependent serine/threonine-protein kinase CDC28
    NP_009718.3
    • Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; regulates metabolism, basal transcription, chromosome dynamics, growth and morphogenesis; transcript induction in osmostress involves antisense RNA; human homologs CDK1, CDK2, CDK3 can complement yeast conditional cdc28 mutants; human CDK1, CDK2 can complement yeast cdc28 null mutant

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      560078..560974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178508.3NP_009718.3  TPA: cyclin-dependent serine/threonine-protein kinase CDC28 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_009718.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00546
      Conserved Domains (2) summary
      PLN00009
      Location:8297
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07835
      Location:8295
      STKc_CDK1_CdkB_like; Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase
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