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    Vamp2 vesicle-associated membrane protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 22318, updated on 22-Apr-2017
    Official Symbol
    Vamp2provided by MGI
    Official Full Name
    vesicle-associated membrane protein 2provided by MGI
    Primary source
    MGI:MGI:1313277
    See related
    Ensembl:ENSMUSG00000020894 Vega:OTTMUSG00000005972
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Syb2; Syb-2; sybII
    Orthologs
    Location:
    11; 11 B3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (69088528..69092381)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (68902030..68905883)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 107 Neighboring gene small nucleolar RNA, C/D box 118 Neighboring gene period circadian clock 1 Neighboring gene nuclear encoded tRNA threonine 5 (anticodon AGT)

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    SNARE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SNARE binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    myosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    syntaxin-1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    syntaxin-1 binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    SNARE complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion regulated exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion regulated exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eosinophil degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    exocytic insertion of neurotransmitter receptor to postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exocytic insertion of neurotransmitter receptor to postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion-dependent exocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SNARE complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    storage vacuole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synaptobrevin 2-SNAP-25-syntaxin-1a complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptobrevin 2-SNAP-25-syntaxin-1a complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex ISO
    Inferred from Sequence Orthology
    more info
     
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    zymogen granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    vesicle-associated membrane protein 2
    Names
    VAMP-2
    synaptobrevin II
    synaptobrevin-2
    vesicle-associated membrane 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009497.3NP_033523.1  vesicle-associated membrane protein 2

      See identical proteins and their annotated locations for NP_033523.1

      Status: PROVISIONAL

      Source sequence(s)
      AL645527
      Consensus CDS
      CCDS24881.1
      UniProtKB/Swiss-Prot
      P63044
      UniProtKB/TrEMBL
      Q8CHR4
      Related
      ENSMUSP00000021273.6, OTTMUSP00000006177, ENSMUST00000021273.12, OTTMUST00000013340
      Conserved Domains (2) summary
      cd15870
      Location:3092
      R-SNARE_VAMP2; SNARE motif of VAMP2
      pfam00957
      Location:28101
      Synaptobrevin; Synaptobrevin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      69088528..69092381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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