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    GOPC golgi associated PDZ and coiled-coil motif containing [ Homo sapiens (human) ]

    Gene ID: 57120, updated on 8-May-2017
    Official Symbol
    GOPCprovided by HGNC
    Official Full Name
    golgi associated PDZ and coiled-coil motif containingprovided by HGNC
    Primary source
    HGNC:HGNC:17643
    See related
    Ensembl:ENSG00000047932 MIM:606845; Vega:OTTHUMG00000015457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAL; FIG; PIST; GOPC1; dJ94G16.2
    Summary
    This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
    Orthologs
    Location:
    6q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (117560269..117602542, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (117881432..117923705, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RAP1B, member of RAS oncogene family pseudogene 3 Neighboring gene RNA, U6 small nuclear 253, pseudogene Neighboring gene discoidin, CUB and LCCL domain containing 1 Neighboring gene nephrocan, pseudogene Neighboring gene uncharacterized LOC101927919

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
    NHGRI GWA Catalog
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases regulate CFTR trafficking, organism-specific biosystem (from REACTOME)
      RHO GTPases regulate CFTR trafficking, organism-specific biosystemActivated RHO GTPase RHOQ (TC10) regulates the trafficking of CFTR (cystic fibrosis transmembrane conductance regulator) by binding to GOPC (Golgi-associated and PDZ and coiled-coil motif-containing ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ion channel binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Golgi to plasma membrane transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    apical protein localization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytoplasmic sequestering of CFTR protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of anion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homooligomerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi-associated vesicle membrane TAS
    Traceable Author Statement
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    lysosomal membrane TAS
    Traceable Author Statement
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    trans-Golgi network transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    trans-Golgi network transport vesicle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    Golgi-associated PDZ and coiled-coil motif-containing protein
    Names
    CFTR-associated ligand
    PDZ protein interacting specifically with TC10
    PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10
    dJ94G16.2 PIST
    fused in glioblastoma
    golgi-associated PDZ and coiled-coil motif containing protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017408.2NP_001017408.1  Golgi-associated PDZ and coiled-coil motif-containing protein isoform b

      See identical proteins and their annotated locations for NP_001017408.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AY033606, BC009553, DA109449, Z85999
      Consensus CDS
      CCDS34523.1
      UniProtKB/Swiss-Prot
      Q9HD26
      Related
      ENSP00000052569.6, OTTHUMP00000017087, ENST00000052569.10, OTTHUMT00000041987
      Conserved Domains (2) summary
      cd00992
      Location:278360
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam07716
      Location:158191
      bZIP_2; Basic region leucine zipper
    2. NM_020399.3NP_065132.1  Golgi-associated PDZ and coiled-coil motif-containing protein isoform a

      See identical proteins and their annotated locations for NP_065132.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AF287894, AY033606, BX419592, DA109449, Z85999
      Consensus CDS
      CCDS5117.1
      UniProtKB/Swiss-Prot
      Q9HD26
      Related
      ENSP00000357484.2, OTTHUMP00000017088, ENST00000368498.6, OTTHUMT00000041988
      Conserved Domains (2) summary
      cd00992
      Location:286368
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam07716
      Location:166199
      bZIP_2; Basic region leucine zipper

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      117560269..117602542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      118145375..118187647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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