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    DCTN1 dynactin subunit 1 [ Homo sapiens (human) ]

    Gene ID: 1639, updated on 5-Nov-2017
    Official Symbol
    DCTN1provided by HGNC
    Official Full Name
    dynactin subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:2711
    See related
    Ensembl:ENSG00000204843 MIM:601143; Vega:OTTHUMG00000129963
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P135; DP-150; DAP-150
    Summary
    This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
    Expression
    Ubiquitous expression in brain (RPKM 71.1), testis (RPKM 43.6) and 25 other tissues See more
    Orthologs
    Location:
    2p13.1
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (74361154..74392087, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74588281..74619214, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NECAP endocytosis associated 1 pseudogene 2 Neighboring gene TATA-box binding protein associated factor 13 pseudogene 2 Neighboring gene DCTN1 antisense RNA 1 Neighboring gene chromosome 2 open reading frame 81 Neighboring gene high mobility group AT-hook 1 pseudogene 8 Neighboring gene WD repeat domain 54

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr relocalizes DCTN1 (p150glued) from the plus ends of microtubules in infected primary human macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    • AURKA Activation by TPX2, organism-specific biosystem (from REACTOME)
      AURKA Activation by TPX2, organism-specific biosystemTPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. ...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Anchoring of the basal body to the plasma membrane, organism-specific biosystem (from REACTOME)
      Anchoring of the basal body to the plasma membrane, organism-specific biosystemCilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core su...
    • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
      Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
    • COPI-independent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
      COPI-independent Golgi-to-ER retrograde traffic, organism-specific biosystemIn addition to the better characterized COPI-dependent retrograde Golgi-to-ER pathway, a second COPI-independent pathway has also been identified. This pathway is RAB6 dependent and transports cargo...
    • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
      COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Centrosome maturation, organism-specific biosystem (from REACTOME)
      Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
    • Cilium Assembly, organism-specific biosystem (from REACTOME)
      Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
    • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
      ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
    • G2/M Transition, organism-specific biosystem (from REACTOME)
      G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
    • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
      Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • IRE1alpha activates chaperones, organism-specific biosystem (from REACTOME)
      IRE1alpha activates chaperones, organism-specific biosystemIRE1-alpha is a single-pass transmembrane protein that resides in the endoplasmic reticulum (ER) membrane. The C-terminus of IRE1-alpha is located in the cytosol; the N-terminus is located in the ER ...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
      Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
    • Loss of Nlp from mitotic centrosomes, organism-specific biosystem (from REACTOME)
      Loss of Nlp from mitotic centrosomes, organism-specific biosystemDuring interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated...
    • Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystem (from REACTOME)
      Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystemIn addition to recruiting proteins and complexes necessary for increased microtubule nucleation, centrosomal maturation involves the loss of proteins involved in interphase microtubule organization ...
    • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
      MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
      Mitotic G2-G2/M phases, organism-specific biosystem
      Mitotic G2-G2/M phases
    • N-cadherin signaling events, organism-specific biosystem (from Pathway Interaction Database)
      N-cadherin signaling events, organism-specific biosystem
      N-cadherin signaling events
    • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
      Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
      Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...
    • Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
      Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemThe kinase activity of PLK1 is required for cell cycle progression as PLK1 phosphorylates and regulates a number of cellular proteins during mitosis. Centrosomic AURKA (Aurora A kinase), catalyticall...
    • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
      Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
    • Unfolded Protein Response (UPR), organism-specific biosystem (from REACTOME)
      Unfolded Protein Response (UPR), organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...
    • Vasopressin-regulated water reabsorption, organism-specific biosystem (from KEGG)
      Vasopressin-regulated water reabsorption, organism-specific biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
    • Vasopressin-regulated water reabsorption, conserved biosystem (from KEGG)
      Vasopressin-regulated water reabsorption, conserved biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    • XBP1(S) activates chaperone genes, organism-specific biosystem (from REACTOME)
      XBP1(S) activates chaperone genes, organism-specific biosystemXbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotri...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: SLC4A5

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    dynein complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    IRE1-mediated unfolded protein response TAS
    Traceable Author Statement
    more info
     
    antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
    Traceable Author Statement
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    centriole-centriole cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ciliary basal body-plasma membrane docking TAS
    Traceable Author Statement
    more info
     
    establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    melanosome transport IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule anchoring at centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nervous system development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear envelope disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    regulation of mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transport along microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell leading edge IEA
    Inferred from Electronic Annotation
    more info
     
    centriolar subdistal appendage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dynactin complex IEA
    Inferred from Electronic Annotation
    more info
     
    dynein complex IEA
    Inferred from Electronic Annotation
    more info
     
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with retromer complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    dynactin subunit 1
    Names
    150 kDa dynein-associated polypeptide
    dynactin 1 (p150, glued homolog, Drosophila)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008735.2 RefSeqGene

      Range
      5001..35934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_237

    mRNA and Protein(s)

    1. NM_001135040.2NP_001128512.1  dynactin subunit 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the 5' coding region and 5' UTR, compared to variant 4. These differences cause translation initiation from an upstream AUG and a protein (isoform 3) with a longer N-terminus containing a CAP-Gly domain, compared to isoform 4.
      Source sequence(s)
      AK314352, BC013978, CA448857, DA315227
      Consensus CDS
      CCDS46341.1
      UniProtKB/Swiss-Prot
      Q14203
      Related
      ENSP00000386843.3, OTTHUMP00000202448, ENST00000409567.7, OTTHUMT00000327943
      Conserved Domains (7) summary
      pfam01302
      Location:3094
      CAP_GLY; CAP-Gly domain
      pfam06112
      Location:78167
      Herpes_capsid; Gammaherpesvirus capsid protein
      pfam08172
      Location:294435
      CASP_C; CASP C terminal
      pfam12455
      Location:505785
      Dynactin; Dynein associated protein
      pfam14915
      Location:207527
      CCDC144C; CCDC144C protein coiled-coil region
      pfam16046
      Location:9321014
      FAM76; FAM76 protein
      cl23943
      Location:226322
      PCRF; PCRF domain
    2. NM_001135041.2NP_001128513.1  dynactin subunit 1 isoform 4

      See identical proteins and their annotated locations for NP_001128513.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the shortest transcript and it encodes the shortest protein (isoform 4).
      Source sequence(s)
      BC013978, BC071583, CA448857, DA111497
      Consensus CDS
      CCDS46342.1
      UniProtKB/Swiss-Prot
      Q14203
      Related
      ENSP00000387270.1, OTTHUMP00000202491, ENST00000409438.5, OTTHUMT00000328053
      Conserved Domains (5) summary
      pfam08172
      Location:180321
      CASP_C; CASP C terminal
      pfam12455
      Location:391671
      Dynactin; Dynein associated protein
      pfam14915
      Location:93413
      CCDC144C; CCDC144C protein coiled-coil region
      pfam16046
      Location:818900
      FAM76; FAM76 protein
      cl23943
      Location:112208
      PCRF; PCRF domain
    3. NM_001190836.1NP_001177765.1  dynactin subunit 1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences in the 5' end, compared to variant 4. These differences cause translation initiation from an upstream AUG and a protein (isoform 5) with a longer N-terminus, compared to isoform 4.
      Source sequence(s)
      AK297286, BC013978, CA448857, DC309469
      Consensus CDS
      CCDS54368.1
      UniProtKB/Swiss-Prot
      Q14203
      Related
      ENSP00000386406.1, OTTHUMP00000202531, ENST00000409240.5, OTTHUMT00000328165
      Conserved Domains (7) summary
      pfam01302
      Location:1377
      CAP_GLY; CAP-Gly domain
      pfam06112
      Location:61150
      Herpes_capsid; Gammaherpesvirus capsid protein
      pfam08172
      Location:277418
      CASP_C; CASP C terminal
      pfam12455
      Location:488768
      Dynactin; Dynein associated protein
      pfam14915
      Location:190510
      CCDC144C; CCDC144C protein coiled-coil region
      pfam16046
      Location:915997
      FAM76; FAM76 protein
      cl23943
      Location:209305
      PCRF; PCRF domain
    4. NM_001190837.1NP_001177766.1  dynactin subunit 1 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences in the 5' end and in the 3' coding region, compared to variant 4. These differences cause translation initiation from an upstream AUG and a protein (isoform 6) with longer N- and C-termini, compared to isoform 4.
      Source sequence(s)
      AK314352, BX640799, CA448857, DA315227, X98801
      Consensus CDS
      CCDS54369.1
      UniProtKB/Swiss-Prot
      Q14203
      UniProtKB/TrEMBL
      Q6MZZ3
      Related
      ENSP00000377571.3, ENST00000394003.7
      Conserved Domains (6) summary
      pfam01302
      Location:3094
      CAP_GLY; CAP-Gly domain
      pfam08172
      Location:307448
      CASP_C; CASP C terminal
      pfam12455
      Location:518798
      Dynactin; Dynein associated protein
      pfam14915
      Location:220540
      CCDC144C; CCDC144C protein coiled-coil region
      pfam16046
      Location:130285
      FAM76; FAM76 protein
      cl23943
      Location:239335
      PCRF; PCRF domain
    5. NM_004082.4NP_004073.2  dynactin subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_004073.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has multiple differences in the 5' UTR, 5' coding region and 3' coding region, compared to variant 4. These differences cause translation initiation from an upstream AUG and a protein (isoform 1) with a longer N-terminus containing a CAP-Gly domain and a longer C-terminus, compared to isoform 4. Isoform 1 is also called p150.
      Source sequence(s)
      BC013978, BX640799, CA448857, DA315227, X98801
      Consensus CDS
      CCDS1939.1
      UniProtKB/Swiss-Prot
      Q14203
      UniProtKB/TrEMBL
      Q6MZZ3
      Related
      ENSP00000354791.3, OTTHUMP00000160423, ENST00000361874.7, OTTHUMT00000252227
      Conserved Domains (6) summary
      pfam01302
      Location:3094
      CAP_GLY; CAP-Gly domain
      pfam08172
      Location:314455
      CASP_C; CASP C terminal
      pfam12455
      Location:525805
      Dynactin; Dynein associated protein
      pfam14915
      Location:227547
      CCDC144C; CCDC144C protein coiled-coil region
      pfam16046
      Location:135292
      FAM76; FAM76 protein
      cl23943
      Location:246342
      PCRF; PCRF domain
    6. NM_023019.3NP_075408.1  dynactin subunit 1 isoform 2

      See identical proteins and their annotated locations for NP_075408.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional in-frame exon in the 3' end, compared to variant 4, resulting in a protein (isoform 2) with a longer C-terminus, compared to isoform 4. Isoform 2 is also called p135.
      Source sequence(s)
      BC013978, BC071583, CA448857, DA111497, X98801
      Consensus CDS
      CCDS46343.1
      UniProtKB/Swiss-Prot
      Q14203
      Related
      ENSP00000487724.1, OTTHUMP00000279639, ENST00000633691.1, OTTHUMT00000485027
      Conserved Domains (5) summary
      pfam08172
      Location:180321
      CASP_C; CASP C terminal
      pfam12455
      Location:391671
      Dynactin; Dynein associated protein
      pfam14915
      Location:93413
      CCDC144C; CCDC144C protein coiled-coil region
      pfam16046
      Location:818900
      FAM76; FAM76 protein
      cl23943
      Location:112208
      PCRF; PCRF domain

    RNA

    1. NR_033935.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains an alternate 5' exon and an additional segment in the 3' end, compared to variant 4. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the additional 3' segment results in an early start codon which renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BX647925, BX647972, CA448857, DC309469
      Related
      ENST00000434055.5, OTTHUMT00000328164

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      74361154..74392087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      74517708..74548641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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