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    CD276 CD276 molecule [ Homo sapiens (human) ]

    Gene ID: 80381, updated on 8-May-2017
    Official Symbol
    CD276provided by HGNC
    Official Full Name
    CD276 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:19137
    See related
    Ensembl:ENSG00000103855 MIM:605715; Vega:OTTHUMG00000137585
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B7H3; B7-H3; B7RP-2; 4Ig-B7-H3
    Summary
    The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
    Orthologs
    Location:
    15q24.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (73683966..73714518)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (73976560..74006859)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NPTN intronic transcript 1 Neighboring gene neuroplastin Neighboring gene uncharacterized LOC105370891 Neighboring gene chromosome 15 open reading frame 59 Neighboring gene C15orf59 antisense RNA 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes.
    NHGRI GWA Catalog
    Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
    NHGRI GWA Catalog
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interferon-gamma biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    CD276 antigen
    Names
    B7 homolog 3
    costimulatory molecule

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051242.1 RefSeqGene

      Range
      5316..35553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024736.1NP_001019907.1  CD276 antigen isoform a precursor

      See identical proteins and their annotated locations for NP_001019907.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK075549, BC062581, CA420873
      Consensus CDS
      CCDS32288.1
      UniProtKB/Swiss-Prot
      Q5ZPR3
      Related
      ENSP00000320084.5, OTTHUMP00000174914, ENST00000318443.9, OTTHUMT00000268979
      Conserved Domains (2) summary
      smart00410
      Location:156237
      IG_like; Immunoglobulin like
      cl11960
      Location:261357
      Ig; Immunoglobulin domain
    2. NM_001329628.1NP_001316557.1  CD276 antigen isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in its 5' coding region compared to variant 1. The encoded isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      AC022188, AC100838, CA420873
      UniProtKB/Swiss-Prot
      Q5ZPR3
    3. NM_001329629.1NP_001316558.1  CD276 antigen isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (c) has a shorter N-terminus and lacks a predicted signal peptide compared to isoform a.
      Source sequence(s)
      AK292711, BC011578, BC062581, CA420873
      UniProtKB/Swiss-Prot
      Q5ZPR3
      UniProtKB/TrEMBL
      A0A0C4DGH0, A8K9J6
      Conserved Domains (2) summary
      smart00410
      Location:1091
      IG_like; Immunoglobulin like
      cl11960
      Location:115211
      Ig; Immunoglobulin domain
    4. NM_025240.2NP_079516.1  CD276 antigen isoform b precursor

      See identical proteins and their annotated locations for NP_079516.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in its 5' coding region compared to variant 1. The encoded isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      AF302102, AK075549, BC062581, CA420873
      Consensus CDS
      CCDS10251.1
      UniProtKB/Swiss-Prot
      Q5ZPR3
      Related
      ENSP00000320058.5, ENST00000318424.9
      Conserved Domains (2) summary
      smart00410
      Location:156238
      IG_like; Immunoglobulin like
      cl11960
      Location:43139
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      73683966..73714518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022638.1XP_016878127.1  CD276 antigen isoform X1

      UniProtKB/Swiss-Prot
      Q5ZPR3
      Conserved Domains (2) summary
      smart00410
      Location:156237
      IG_like; Immunoglobulin like
      cl11960
      Location:261357
      Ig; Immunoglobulin domain
    2. XM_005254700.4XP_005254757.1  CD276 antigen isoform X1

      See identical proteins and their annotated locations for XP_005254757.1

      UniProtKB/Swiss-Prot
      Q5ZPR3
      Conserved Domains (2) summary
      smart00410
      Location:156237
      IG_like; Immunoglobulin like
      cl11960
      Location:261357
      Ig; Immunoglobulin domain
    3. XM_011522095.2XP_011520397.1  CD276 antigen isoform X1

      See identical proteins and their annotated locations for XP_011520397.1

      UniProtKB/Swiss-Prot
      Q5ZPR3
      Conserved Domains (2) summary
      smart00410
      Location:156237
      IG_like; Immunoglobulin like
      cl11960
      Location:261357
      Ig; Immunoglobulin domain
    4. XM_011522096.2XP_011520398.1  CD276 antigen isoform X1

      See identical proteins and their annotated locations for XP_011520398.1

      UniProtKB/Swiss-Prot
      Q5ZPR3
      Conserved Domains (2) summary
      smart00410
      Location:156237
      IG_like; Immunoglobulin like
      cl11960
      Location:261357
      Ig; Immunoglobulin domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      74094539..74124834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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