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    Prnp prion protein [ Mus musculus (house mouse) ]

    Gene ID: 19122, updated on 15-Oct-2017
    Official Symbol
    Prnpprovided by MGI
    Official Full Name
    prion proteinprovided by MGI
    Primary source
    MGI:MGI:97769
    See related
    Ensembl:ENSMUSG00000079037 Vega:OTTMUSG00000014846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PrP; PrPC; Sinc; CD230; PrPSc; Prn-i; Prn-p; PrP<C>; AA960666; AI325101; prP27-30; prP33-35C
    Orthologs
    Location:
    2 F2; 2 64.07 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (131909928..131938436)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (131735664..131764167)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene endogenous retroviral sequence 3 Neighboring gene laminin receptor 1 (ribosomal protein SA), pseudogene 1 Neighboring gene prion protein readthrough transcript Neighboring gene prion like protein doppel Neighboring gene Ras association (RalGDS/AF-6) domain family member 2 Neighboring gene predicted gene, 39939

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Ferroptosis, organism-specific biosystem (from KEGG)
      Ferroptosis, organism-specific biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
    • Ferroptosis, conserved biosystem (from KEGG)
      Ferroptosis, conserved biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
    • NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
      NCAM signaling for neurite out-growth, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • NCAM1 interactions, organism-specific biosystem (from REACTOME)
      NCAM1 interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Prion diseases, organism-specific biosystem (from KEGG)
      Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
    • Prion diseases, conserved biosystem (from KEGG)
      Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Readthrough Prn

    Readthrough gene: Prn, Included gene: Prnd

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    amyloid-beta binding TAS
    Traceable Author Statement
    more info
    PubMed 
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    copper ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    cupric ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cuprous ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    glycosaminoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    lamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transducer activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    type 5 metabotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    type 5 metabotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT amyloid precursor protein metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    calcium-mediated signaling using intracellular calcium source IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    calcium-mediated signaling using intracellular calcium source ISO
    Inferred from Sequence Orthology
    more info
     
    cellular copper ion homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to amyloid-beta IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to copper ion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    learning or memory IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    modulation of age-related behavioral decline IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of amyloid precursor protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of amyloid-beta formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of calcineurin-NFAT signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dendritic spine maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-17 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleobase-containing compound metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein targeting to membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion import across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of intracellular calcium activated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of peptidyl-tyrosine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of potassium ion transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to amyloid-beta IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    response to copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with amyloid-beta complex ISO
    Inferred from Sequence Orthology
    more info
     
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane raft TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278256.1NP_001265185.1  major prion protein precursor

      See identical proteins and their annotated locations for NP_001265185.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK158908, AK159056, AV361844, CK622972
      Consensus CDS
      CCDS16766.1
      UniProtKB/Swiss-Prot
      P04925
      UniProtKB/TrEMBL
      Q4FJQ7
      Conserved Domains (3) summary
      smart00157
      Location:23241
      PRP; Major prion protein
      pfam00377
      Location:133252
      Prion; Prion/Doppel alpha-helical domain
      pfam11587
      Location:128
      Prion_bPrPp; Major prion protein bPrPp - N terminal
    2. NM_011170.3NP_035300.1  major prion protein precursor

      See identical proteins and their annotated locations for NP_035300.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK148061, AK158908, AV361844, CK622972
      Consensus CDS
      CCDS16766.1
      UniProtKB/Swiss-Prot
      P04925
      UniProtKB/TrEMBL
      Q3UG89, Q4FJQ7
      Related
      ENSMUSP00000088833.6, OTTMUSP00000015760, ENSMUST00000091288.12, OTTMUST00000035259
      Conserved Domains (3) summary
      smart00157
      Location:23241
      PRP; Major prion protein
      pfam00377
      Location:133252
      Prion; Prion/Doppel alpha-helical domain
      pfam11587
      Location:128
      Prion_bPrPp; Major prion protein bPrPp - N terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      131909928..131938436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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