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    SIRT2 sirtuin 2 [ Homo sapiens (human) ]

    Gene ID: 22933, updated on 23-Jul-2017
    Official Symbol
    SIRT2provided by HGNC
    Official Full Name
    sirtuin 2provided by HGNC
    Primary source
    HGNC:HGNC:10886
    See related
    Ensembl:ENSG00000068903 MIM:604480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIR2; SIR2L; SIR2L2
    Summary
    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
    Orthologs
    Location:
    19q13.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (38878555..38899862, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39369195..39390502, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene Ras and Rab interactor like Neighboring gene NFKB inhibitor beta Neighboring gene coiled-coil glutamate rich protein 2 Neighboring gene seryl-tRNA synthetase 2, mitochondrial Neighboring gene mitochondrial ribosomal protein S12

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ35621, FLJ37491

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT NAD+ ADP-ribosyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    NAD+ binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD-dependent histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD-dependent histone deacetylase activity (H4-K16 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD-dependent protein deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD-dependent protein deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    beta-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tubulin deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    catabolic autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to caloric restriction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to epinephrine stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to hepatocyte growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to molecule of bacterial origin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    chromatin silencing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    chromatin silencing at rDNA NAS
    Non-traceable Author Statement
    more info
    PubMed 
    chromatin silencing at telomere NAS
    Non-traceable Author Statement
    more info
    PubMed 
    gene silencing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    hepatocyte growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H3 deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H4 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylation TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    myelination in peripheral nervous system ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of NLRP3 inflammasome complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of catabolic autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of oligodendrocyte progenitor proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of reactive oxygen species metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of striated muscle tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-lysine deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of attachment of spindle microtubules to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of execution phase of apoptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of meiotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of oocyte maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ADP-ribosylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    NOT protein ADP-ribosylation TAS
    Traceable Author Statement
    more info
    PubMed 
    protein deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of exit from mitosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to redox state NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ripoptosome assembly involved in necroptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    substantia nigra development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    tubulin deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tubulin deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tubulin deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    Schmidt-Lanterman incisure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin silencing complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glial cell projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    juxtaparanode region of axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lateral loop ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    meiotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nuclear heterochromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    paranodal junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    paranode region of axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    NAD-dependent protein deacetylase sirtuin-2
    Names
    NAD-dependent deacetylase sirtuin-2
    SIR2-like protein 2
    regulatory protein SIR2 homolog 2
    silent information regulator 2
    sir2-related protein type 2
    sirtuin type 2
    NP_001180215.1
    NP_036369.2
    NP_085096.1
    XP_006723174.1
    XP_011524956.1
    XP_011524957.1
    XP_016881989.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193286.1NP_001180215.1  NAD-dependent protein deacetylase sirtuin-2 isoform 3

      See identical proteins and their annotated locations for NP_001180215.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' region, resulting in a downstream in-frame AUG start codon, and also lacks a big segment in the 3' region, resulting in a frame-shift, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, and a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AF131800, BF529906, DA541045
      Consensus CDS
      CCDS74361.1
      UniProtKB/Swiss-Prot
      Q8IXJ6
      UniProtKB/TrEMBL
      A0A0A0MRF5
      Related
      ENSP00000351809.6, ENST00000358931.9
      Conserved Domains (1) summary
      cd01408
      Location:40228
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    2. NM_012237.3NP_036369.2  NAD-dependent protein deacetylase sirtuin-2 isoform 1

      See identical proteins and their annotated locations for NP_036369.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF083107, BF529906, DA705079
      Consensus CDS
      CCDS12523.1
      UniProtKB/Swiss-Prot
      Q8IXJ6
      Related
      ENSP00000249396.7, ENST00000249396.11
      Conserved Domains (2) summary
      cd01408
      Location:77331
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
      pfam16602
      Location:350388
      USP19_linker; Linker region of USP19 deubiquitinase
    3. NM_030593.2NP_085096.1  NAD-dependent protein deacetylase sirtuin-2 isoform 2

      See identical proteins and their annotated locations for NP_085096.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' region, resulting in a downstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      BC003012, BF529906, DA541045
      Consensus CDS
      CCDS46069.1
      UniProtKB/Swiss-Prot
      Q8IXJ6
      UniProtKB/TrEMBL
      A0A024R0G8
      Related
      ENSP00000375931.2, ENST00000392081.6
      Conserved Domains (2) summary
      cd01408
      Location:40294
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
      pfam16602
      Location:313351
      USP19_linker; Linker region of USP19 deubiquitinase

    RNA

    1. NR_034146.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks the 5' two exons but has an alternate 5' segment, resulting in an upstream open reading frame (uORF) with strong Kozak signal, as compared to variant 1. The uORF overlaps the downstream ORF (dORF), and inhibits the protein translation from the dORF. Therefore, this transcript is a nonsense-mediated mRNA decay candidate and can not make a functional protein.
      Source sequence(s)
      AK290716, BF346568, BF529906

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      38878555..38899862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526655.1XP_011524957.1  NAD-dependent protein deacetylase sirtuin-2 isoform X2

      See identical proteins and their annotated locations for XP_011524957.1

      UniProtKB/Swiss-Prot
      Q8IXJ6
      Conserved Domains (2) summary
      cd01408
      Location:7261
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
      pfam16602
      Location:280318
      USP19_linker; Linker region of USP19 deubiquitinase
    2. XM_011526654.1XP_011524956.1  NAD-dependent protein deacetylase sirtuin-2 isoform X1

      See identical proteins and their annotated locations for XP_011524956.1

      UniProtKB/Swiss-Prot
      Q8IXJ6
      UniProtKB/TrEMBL
      A0A024R0G8
      Related
      ENSP00000481932.1, ENST00000613542.4
      Conserved Domains (2) summary
      cd01408
      Location:40294
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
      pfam16602
      Location:313351
      USP19_linker; Linker region of USP19 deubiquitinase
    3. XM_006723111.1XP_006723174.1  NAD-dependent protein deacetylase sirtuin-2 isoform X1

      See identical proteins and their annotated locations for XP_006723174.1

      UniProtKB/Swiss-Prot
      Q8IXJ6
      UniProtKB/TrEMBL
      A0A024R0G8
      Conserved Domains (2) summary
      cd01408
      Location:40294
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
      pfam16602
      Location:313351
      USP19_linker; Linker region of USP19 deubiquitinase
    4. XM_017026500.1XP_016881989.1  NAD-dependent protein deacetylase sirtuin-2 isoform X3

    RNA

    1. XR_001753639.1 RNA Sequence

    2. XR_001753638.1 RNA Sequence

    Reference GRCh38.p7 PATCHES

    Genomic

    1. NW_014040929.1 Reference GRCh38.p7 PATCHES

      Range
      288227..309534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      39369665..39390970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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