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    Mapk6 mitogen-activated protein kinase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58840, updated on 26-Sep-2017
    Official Symbol
    Mapk6provided by RGD
    Official Full Name
    mitogen-activated protein kinase 6provided by RGD
    Primary source
    RGD:62087
    See related
    Ensembl:ENSRNOG00000009381
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ERK3
    Summary
    kinase that is activated following insulin and Ngf treatment [RGD, Feb 2006]
    Expression
    Biased expression in Muscle (RPKM 315.1), Testes (RPKM 287.0) and 9 other tissues See more
    Orthologs
    Location:
    8q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (82328013..82351108, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (81931183..81954196, complement)

    Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene G protein subunit beta 5 Neighboring gene BCL2 like 10 Neighboring gene uncharacterized LOC102551227 Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC124957

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to organic substance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of dendritic spine development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    septin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    septin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    mitogen-activated protein kinase 6
    Names
    ERK-3
    MAP kinase 6
    MAPK 6
    extracellular signal-regulated kinase 3
    p55-MAPK
    NP_113810.2
    XP_006243471.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031622.2NP_113810.2  mitogen-activated protein kinase 6

      See identical proteins and their annotated locations for NP_113810.2

      Status: VALIDATED

      Source sequence(s)
      BC109380, BE104187, CB742965
      UniProtKB/Swiss-Prot
      P27704
      Related
      ENSRNOP00000013053.3, ENSRNOT00000013053.6
      Conserved Domains (2) summary
      cd07854
      Location:14355
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
      smart00220
      Location:20316
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

      Range
      82328013..82351108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243409.3XP_006243471.1  mitogen-activated protein kinase 6 isoform X1

      See identical proteins and their annotated locations for XP_006243471.1

      UniProtKB/Swiss-Prot
      P27704
      Conserved Domains (2) summary
      cd07854
      Location:14355
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
      smart00220
      Location:20316
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    Alternate Rn_Celera

    Genomic

    1. AC_000076.1 Alternate Rn_Celera

      Range
      75936355..75959409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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