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    ANAPC11 anaphase promoting complex subunit 11 [ Homo sapiens (human) ]

    Gene ID: 51529, updated on 9-Jul-2017
    Official Symbol
    ANAPC11provided by HGNC
    Official Full Name
    anaphase promoting complex subunit 11provided by HGNC
    Primary source
    HGNC:HGNC:14452
    See related
    Ensembl:ENSG00000141552 MIM:614534; Vega:OTTHUMG00000177982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APC11; Apc11p; HSPC214
    Orthologs
    Location:
    17q25.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (81890790..81900533)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79849599..79858363)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985024 Neighboring gene Rho GDP dissociation inhibitor alpha Neighboring gene Aly/REF export factor Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B Neighboring gene sirtuin 7

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • APC-Cdc20 mediated degradation of Nek2A, organism-specific biosystem (from REACTOME)
      APC-Cdc20 mediated degradation of Nek2A, organism-specific biosystemLike Cyclin A, NIMA-related kinase 2A (Nek2A) is degraded during pro-metaphase in a checkpoint-independent manner.
    • APC/C complex, organism-specific biosystem (from KEGG)
      APC/C complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • APC/C complex, conserved biosystem (from KEGG)
      APC/C complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
    • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
      APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
    • APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystemThe degradation of cyclin B1, which appears to occur at the mitotic spindle, is delayed until the metaphase /anaphase transition by the spindle assembly checkpoint and is required in order for sister...
    • APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystemThe separation of sister chromatids in anaphase requires the destruction of the anaphase inhibitor, securin. Securin associates with and inactivates the protease, separase. Separase cleaves the cohe...
    • APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemFollowing phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the ...
    • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
      APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemFrom late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Gemin...
    • APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, organism-specific biosystem (from REACTOME)
      APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, organism-specific biosystemAPC:CDC20 mediates the degradation of a number of cell cycle proteins including Cyclin A and Nek2A.
    • Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemAPC/C:Cdc20 is first activated at the prometaphase/metaphase transition through phosphorylation of core subunits of the APC/C by mitotic kinases as well as recruitment of the APC/C activator protein ...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystem (from REACTOME)
      Autodegradation of Cdh1 by Cdh1:APC/C, organism-specific biosystemCdh1 is degraded by the APC/C during in G1 and G0. This auto-regulation may contribute to reducing the levels of Cdh1 levels during G1 and G0 (Listovsky et al., 2004).
    • Cdc20:Phospho-APC/C mediated degradation of Cyclin A, organism-specific biosystem (from REACTOME)
      Cdc20:Phospho-APC/C mediated degradation of Cyclin A, organism-specific biosystemCyclin A, functions in mitosis as well as DNA replication and is degraded in the interim by the APC/C to permit normal chromosome segregation, cell division, and the onset of S phase (see Lukas an...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cellular Senescence, organism-specific biosystem (from REACTOME)
      Cellular Senescence, organism-specific biosystemCellular senescence involves irreversible growth arrest accompanied by phenotypic changes such as enlarged morphology, reorganization of chromatin through formation of senescence-associated heterochr...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystem (from REACTOME)
      Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystemThe activity of the APC/C must be appropriately regulated during the cell cycle to ensure the timely degradation of its substrates. Of particular importance is the conversion from APC/C:Cdc20 to APC...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inactivation of APC/C via direct inhibition of the APC/C complex, organism-specific biosystem (from REACTOME)
      Inactivation of APC/C via direct inhibition of the APC/C complex, organism-specific biosystemIn the direct inhibition model, the cytosolic Mitotic Checkpoint Complex, consisting of hBUBR1, hBUB3, Cdc20 and Mad2, directly inhibits APC/C by binding to it.
    • Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, organism-specific biosystem (from REACTOME)
      Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, organism-specific biosystemThe target of the mitotic checkpoint is the Anaphase Promoting Complex/Cyclosome (APC/C) an E3 ubiquitin ligase that targets proteins whose destruction is essential for mitotic exit. Currently, there...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
    • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
    • Mitotic Spindle Checkpoint, organism-specific biosystem (from REACTOME)
      Mitotic Spindle Checkpoint, organism-specific biosystemThe mitotic checkpoint or spindle assembly checkpoint is an evolutionarily conserved mechanism that ensures that cells with misaligned chromosomes do not exit mitosis and divide to form aneuploid cel...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Phosphorylation of the APC/C, organism-specific biosystem (from REACTOME)
      Phosphorylation of the APC/C, organism-specific biosystemPhosphorylation of APC subunits is required for Cdc20 mediated activation by of the APC/C at the metaphase anaphase transition (Kramer et al., 2000). While the kinases responsible for phosphorylation...
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
      Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemThe APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zacha...
    • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
      Regulation of mitotic cell cycle, organism-specific biosystem
      Regulation of mitotic cell cycle
    • Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystem (from REACTOME)
      Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystemThe culture medium of senescent cells in enriched in secreted proteins when compared with the culture medium of quiescent i.e. presenescent cells and these secreted proteins constitute the so-called ...
    • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
      Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: NPB

    Homology

    Clone Names

    • MGC882

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cullin family protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    anaphase-promoting complex subunit 11
    Names
    APC11 anaphase promoting complex subunit 11 homolog
    anaphase promoting complex subunit 11 (yeast APC11 homolog)
    cyclosome subunit 11
    hepatocellular carcinoma-associated RING finger protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002244.2NP_001002244.1  anaphase-promoting complex subunit 11 isoform 1

      See identical proteins and their annotated locations for NP_001002244.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK308091, BC000607, HY067392
      Consensus CDS
      CCDS32769.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      UniProtKB/TrEMBL
      A0A024R8S1
      Related
      ENSP00000349957.3, OTTHUMP00000258269, ENST00000357385.7, OTTHUMT00000440101
      Conserved Domains (2) summary
      pfam12678
      Location:237
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:151
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_001002245.2NP_001002245.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001002245.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AK308091, BC000607, HY067392
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000461648.2, OTTHUMP00000258272, ENST00000571024.6, OTTHUMT00000440104
      Conserved Domains (2) summary
      pfam12678
      Location:277
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:184
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    3. NM_001002246.2NP_001002246.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001002246.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site and contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AF151048, AK308091, BC000607, HY067392
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000460064.2, OTTHUMP00000258270, ENST00000574924.6, OTTHUMT00000440102
      Conserved Domains (2) summary
      pfam12678
      Location:277
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:184
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    4. NM_001002247.2NP_001002247.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001002247.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AK308091, BC000607, HY067392
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000463640.1, OTTHUMP00000259242, ENST00000579978.5, OTTHUMT00000441617
      Conserved Domains (2) summary
      pfam12678
      Location:277
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:184
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    5. NM_001002248.2NP_001002248.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001002248.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site and contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AF151048, AK308091, BC000607, HY067392
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000339695.5, OTTHUMP00000258268, ENST00000344877.9, OTTHUMT00000440100
      Conserved Domains (2) summary
      pfam12678
      Location:277
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:184
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    6. NM_001002249.2NP_001002249.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001002249.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an exon and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AK308091, BC066308, BM845909
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000376181.3, OTTHUMP00000258273, ENST00000392376.7, OTTHUMT00000440105
      Conserved Domains (2) summary
      pfam12678
      Location:277
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:184
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    7. NM_001289414.1NP_001276343.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001276343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks an exon and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AA356010, AK308091, AW965775
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000458143.1, OTTHUMP00000258266, ENST00000571570.5, OTTHUMT00000440098
      Conserved Domains (2) summary
      pfam12678
      Location:277
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:184
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    8. NM_001289415.1NP_001276344.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001276344.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AK308091, BC171898, HY067392
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000458265.2, OTTHUMP00000258271, ENST00000572851.6, OTTHUMT00000440103
      Conserved Domains (2) summary
      pfam12678
      Location:277
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:184
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    9. NM_001289416.1NP_001276345.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001276345.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) lacks an exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AK308091, BC066308, BM845909, BY796995
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000463598.1, OTTHUMP00000259250, ENST00000583839.1, OTTHUMT00000441625
      Conserved Domains (2) summary
      pfam12678
      Location:277
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:184
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    10. NM_001289417.1NP_001276346.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001276346.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) uses an alternate splice site and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AC145207, AK308091, CA335305, HY067392
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000464615.1, OTTHUMP00000259247, ENST00000578550.5, OTTHUMT00000441622
      Conserved Domains (2) summary
      pfam12678
      Location:277
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:184
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    11. NM_001289418.1NP_001276347.1  anaphase-promoting complex subunit 11 isoform 3

      See identical proteins and their annotated locations for NP_001276347.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) uses an alternate splice site in the 5' UTR and an alternate splice site in the 5' coding region, and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1. Variants 12 and 13 encode isoform 3.
      Source sequence(s)
      AI356704, AK308091, DB501853, DB573049, HY067392
      Consensus CDS
      CCDS74180.1
      UniProtKB/TrEMBL
      A0A087X1B5
    12. NM_001289419.1NP_001276348.1  anaphase-promoting complex subunit 11 isoform 3

      See identical proteins and their annotated locations for NP_001276348.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) uses an alternate splice site and contains an alternate exon in the 5' UTR, uses an alternate splice site in the 5' coding region, and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1. Variants 12 and 13 encode isoform 3.
      Source sequence(s)
      AC145207, AK308091, HY067392, HY142453
      Consensus CDS
      CCDS74180.1
      UniProtKB/TrEMBL
      A0A087X1B5
      Related
      ENSP00000484031.1, ENST00000612413.4
    13. NM_001289420.1NP_001276349.1  anaphase-promoting complex subunit 11 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) lacks an exon and contains two alternate exons in the 5' UTR, and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC145207, AK308091, BC066308, BM762129, BM845909
      UniProtKB/Swiss-Prot
      Q9NYG5
      Conserved Domains (2) summary
      pfam12678
      Location:237
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:151
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    14. NM_016476.11NP_057560.8  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_057560.8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AF151048, AK308091, BC000607, BF512771, HY067392
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      Q9NYG5
      Related
      ENSP00000459200.2, OTTHUMP00000259246, ENST00000571874.6, OTTHUMT00000441621
      Conserved Domains (2) summary
      pfam12678
      Location:277
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:184
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      81890790..81900533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      79934870..79944613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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