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    KIF21A kinesin family member 21A [ Homo sapiens (human) ]

    Gene ID: 55605, updated on 14-Apr-2018
    Official Symbol
    KIF21Aprovided by HGNC
    Official Full Name
    kinesin family member 21Aprovided by HGNC
    Primary source
    HGNC:HGNC:19349
    See related
    Ensembl:ENSG00000139116 MIM:608283; Vega:OTTHUMG00000169335
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FEOM1; CFEOM1; FEOM3A
    Summary
    This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
    Expression
    Broad expression in brain (RPKM 25.3), kidney (RPKM 9.6) and 22 other tissues See more
    Orthologs
    Location:
    12q12
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (39293228..39443390, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (39687030..39837192, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984484 Neighboring gene long intergenic non-protein coding RNA 2406 Neighboring gene uncharacterized LOC101927019 Neighboring gene ribosomal protein L7a pseudogene Neighboring gene ATP binding cassette subfamily D member 2 Neighboring gene chromosome 12 open reading frame 40

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
      COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
      Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
      Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
    • Kinesins, organism-specific biosystem (from REACTOME)
      Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ20052, KIAA1708, DKFZp779C159

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    kinesin-like protein KIF21A
    Names
    kinesin-like protein KIF2
    renal carcinoma antigen NY-REN-62

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017067.1 RefSeqGene

      Range
      5001..155163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001173463.1NP_001166934.1  kinesin-like protein KIF21A isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks four in-frame exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AB051495, AB290166, AC084373, AW131223, BC136414
      Consensus CDS
      CCDS53775.1
      UniProtKB/Swiss-Prot
      Q7Z4S6
      Related
      ENSP00000445606.2, OTTHUMP00000240842, ENST00000544797.6, OTTHUMT00000403580
      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13081618
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:655791
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:13021615
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:649786
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13531412
      7WD40; WD40 repeat [structural motif]
    2. NM_001173464.1NP_001166935.1  kinesin-like protein KIF21A isoform 1

      See identical proteins and their annotated locations for NP_001166935.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB051495, AB290166, AW131223, AY368076
      Consensus CDS
      CCDS53776.1
      UniProtKB/Swiss-Prot
      Q7Z4S6
      Related
      ENSP00000354878.5, OTTHUMP00000240843, ENST00000361418.9, OTTHUMT00000403581
      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13451655
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:13391652
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13901449
      7WD40; WD40 repeat [structural motif]
    3. NM_001173465.1NP_001166936.1  kinesin-like protein KIF21A isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks four in-frame exons in the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AB051495, AB290166, AC084373, AC090668, AM177179, AW131223, BC041430, DA293947
      Consensus CDS
      CCDS53774.1
      UniProtKB/Swiss-Prot
      Q7Z4S6
      Related
      ENSP00000438075.2, OTTHUMP00000240844, ENST00000541463.6, OTTHUMT00000403582
      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:12921602
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:655791
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:12861599
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:649786
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13371396
      7WD40; WD40 repeat [structural motif]
    4. NM_017641.3NP_060111.2  kinesin-like protein KIF21A isoform 2

      See identical proteins and their annotated locations for NP_060111.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB290166, AC084373, AW131223
      Consensus CDS
      CCDS31773.1
      UniProtKB/Swiss-Prot
      Q7Z4S6
      Related
      ENSP00000354851.3, OTTHUMP00000240839, ENST00000361961.7, OTTHUMT00000403577
      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13321642
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:655791
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:13261639
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:649786
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13771436
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      39293228..39443390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019609.2XP_016875098.1  kinesin-like protein KIF21A isoform X14

    2. XM_006719493.3XP_006719556.1  kinesin-like protein KIF21A isoform X7

      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13261636
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:655791
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:13201633
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:649786
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13711430
      7WD40; WD40 repeat [structural motif]
    3. XM_017019611.2XP_016875100.1  kinesin-like protein KIF21A isoform X16

    4. XM_017019608.2XP_016875097.1  kinesin-like protein KIF21A isoform X9

    5. XM_017019607.2XP_016875096.1  kinesin-like protein KIF21A isoform X5

    6. XM_005269010.3XP_005269067.1  kinesin-like protein KIF21A isoform X4

      Related
      ENSP00000490369.1, OTTHUMP00000281790, ENST00000636569.1
      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13331643
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:655791
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:13271640
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:649786
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13781437
      7WD40; WD40 repeat [structural motif]
    7. XM_011538556.3XP_011536858.1  kinesin-like protein KIF21A isoform X8

      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13231633
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:13171630
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13681427
      7WD40; WD40 repeat [structural motif]
    8. XM_017019610.2XP_016875099.1  kinesin-like protein KIF21A isoform X15

    9. XM_005269009.3XP_005269066.1  kinesin-like protein KIF21A isoform X3

      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13391649
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:13331646
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13841443
      7WD40; WD40 repeat [structural motif]
    10. XM_005269014.3XP_005269071.1  kinesin-like protein KIF21A isoform X13

      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:12851595
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:12791592
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13301389
      7WD40; WD40 repeat [structural motif]
    11. XM_005269013.3XP_005269070.1  kinesin-like protein KIF21A isoform X12

      UniProtKB/Swiss-Prot
      Q7Z4S6
      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:12981608
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:12921605
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13431402
      7WD40; WD40 repeat [structural motif]
    12. XM_006719494.3XP_006719557.1  kinesin-like protein KIF21A isoform X11

      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13021612
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:12961609
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13471406
      7WD40; WD40 repeat [structural motif]
    13. XM_005269012.3XP_005269069.1  kinesin-like protein KIF21A isoform X10

      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13031613
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:12971610
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13481407
      7WD40; WD40 repeat [structural motif]
    14. XM_005269011.3XP_005269068.1  kinesin-like protein KIF21A isoform X6

      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13281638
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:13221635
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13731432
      7WD40; WD40 repeat [structural motif]
    15. XM_005269008.3XP_005269065.1  kinesin-like protein KIF21A isoform X2

      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13411651
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:13351648
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13861445
      7WD40; WD40 repeat [structural motif]
    16. XM_005269007.3XP_005269064.1  kinesin-like protein KIF21A isoform X1

      UniProtKB/Swiss-Prot
      Q7Z4S6
      Conserved Domains (7) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13461656
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:13401653
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:13911450
      7WD40; WD40 repeat [structural motif]
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