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    VCL vinculin [ Gallus gallus (chicken) ]

    Gene ID: 396422, updated on 11-May-2017
    Symbol
    VCLprovided by CGNC
    Full Name
    vinculinprovided by CGNC
    Primary source
    CGNC:3778
    See related
    Ensembl:ENSGALG00000005079
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    Location:
    chromosome: 6
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Gallus_gallus-5.0 (GCF_000002315.4) 6 NC_006093.4 (15392444..15448529, complement)
    102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 6 NC_006093.3 (14961415..15014936, complement)

    Chromosome 6 - NC_006093.4Genomic Context describing neighboring genes Neighboring gene adenosine kinase Neighboring gene adaptor related protein complex 3 mu 1 subunit Neighboring gene plasminogen activator, urokinase Neighboring gene uncharacterized LOC107053655 Neighboring gene calcium/calmodulin dependent protein kinase II gamma

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystem
      Regulation of Actin Cytoskeleton
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    alpha-actinin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alpha-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cadherin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    dystroglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    muscle alpha-actinin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    vinculin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    adherens junction assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    morphogenesis of an epithelium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    costamere ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    fascia adherens IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    inner dense plaque of desmosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    muscle tendon junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    outer dense plaque of desmosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    podosome IEA
    Inferred from Electronic Annotation
    more info
     
    sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skeletal muscle myofibril IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT smooth muscle dense body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    terminal web IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zonula adherens IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    vinculin
    Names
    metavinculin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205441.1NP_990772.1  vinculin

      See identical proteins and their annotated locations for NP_990772.1

      Status: PROVISIONAL

      Source sequence(s)
      J04126
      UniProtKB/Swiss-Prot
      P12003
      Related
      ENSGALP00000048583.1, ENSGALT00000061988.1
      Conserved Domains (1) summary
      pfam01044
      Location:661066
      Vinculin; Vinculin family

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Gallus_gallus-5.0 Primary Assembly

    Genomic

    1. NC_006093.4 Reference Gallus_gallus-5.0 Primary Assembly

      Range
      15392444..15448529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015288203.1XP_015143689.1  vinculin isoform X4

      UniProtKB/Swiss-Prot
      P12003
      UniProtKB/TrEMBL
      F1NYY0
      Related
      ENSGALP00000008131.5, ENSGALT00000008145.5
      Conserved Domains (1) summary
      pfam01044
      Location:661135
      Vinculin; Vinculin family
    2. XM_015288200.1XP_015143686.1  vinculin isoform X1

      Conserved Domains (1) summary
      pfam01044
      Location:661067
      Vinculin; Vinculin family
    3. XM_015288201.1XP_015143687.1  vinculin isoform X2

      Conserved Domains (1) summary
      pfam01044
      Location:66985
      Vinculin; Vinculin family
    4. XM_015288202.1XP_015143688.1  vinculin isoform X3

      Conserved Domains (1) summary
      pfam01044
      Location:66916
      Vinculin; Vinculin family
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