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    ALPI alkaline phosphatase, intestinal [ Homo sapiens (human) ]

    Gene ID: 248, updated on 22-Apr-2017
    Official Symbol
    ALPIprovided by HGNC
    Official Full Name
    alkaline phosphatase, intestinalprovided by HGNC
    Primary source
    HGNC:HGNC:437
    See related
    Ensembl:ENSG00000163295 MIM:171740; Vega:OTTHUMG00000133258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IAP
    Summary
    There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014]
    Orthologs
    Location:
    2q37.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (232456112..232460745)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (233320833..233325455)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene endothelin converting enzyme like 1 pseudogene 1 Neighboring gene DIS3 like 3'-5' exoribonuclease 2 pseudogene 1 Neighboring gene endothelin converting enzyme like 1 Neighboring gene protease, serine 56

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Cells exposed in vitro to HIV-1 gp120 show a defect in inositol polyphosphate-mediated signal transduction resulting from the downregulation of inositol (1,3,4,5)P4 5-phosphomonoesterase (PME) by gp120 PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    alkaline phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    alkaline phosphatase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    alkaline phosphatase activity TAS
    Traceable Author Statement
    more info
     
    magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    C-terminal protein lipidation TAS
    Traceable Author Statement
    more info
     
    dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    digestion TAS
    Traceable Author Statement
    more info
     
    phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    intestinal-type alkaline phosphatase
    Names
    Kasahara isozyme
    alkaline phosphomonoesterase
    glycerophosphatase
    intestinal alkaline phosphatase
    NP_001622.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001631.4NP_001622.2  intestinal-type alkaline phosphatase precursor

      See identical proteins and their annotated locations for NP_001622.2

      Status: REVIEWED

      Source sequence(s)
      AC068134, BC132678, DA376676
      Consensus CDS
      CCDS2492.1
      UniProtKB/Swiss-Prot
      P09923
      UniProtKB/TrEMBL
      A0A024R4A2
      Related
      ENSP00000295463.3, OTTHUMP00000164357, ENST00000295463.3, OTTHUMT00000257035
      Conserved Domains (1) summary
      pfam00245
      Location:52487
      Alk_phosphatase; Alkaline phosphatase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      232456112..232460745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      233326941..233331574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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