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    Glrx glutaredoxin [ Mus musculus (house mouse) ]

    Gene ID: 93692, updated on 1-May-2017
    Official Symbol
    Glrxprovided by MGI
    Official Full Name
    glutaredoxinprovided by MGI
    Primary source
    MGI:MGI:2135625
    See related
    Ensembl:ENSMUSG00000021591 Vega:OTTMUSG00000020964
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Grx1; Glrx1; TTase; C86710; D13Wsu156e
    Orthologs
    Location:
    13 C1; 13 40.95 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (75839873..75850151)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (75977334..75987599)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene elongation factor RNA polymerase II 2 Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 41005 Neighboring gene Rho-related BTB domain containing 3 Neighboring gene WD repeat domain 77 pseudogene Neighboring gene ribosomal protein S2 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    electron carrier activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutathione disulfide oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein disulfide oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-disulfide reductase (glutathione) activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to estradiol stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hydrogen peroxide-mediated programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell adhesion molecule production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    glutaredoxin-1
    Names
    TTase-1
    glutaredoxin (thioltransferase)
    glutaredoxin 1 (thioltransferase)
    thioltransferase-1
    NP_444338.2
    XP_006517540.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053108.4NP_444338.2  glutaredoxin-1

      See identical proteins and their annotated locations for NP_444338.2

      Status: VALIDATED

      Source sequence(s)
      AK153086, BY272278, CO796000
      Consensus CDS
      CCDS26651.1
      UniProtKB/Swiss-Prot
      Q9QUH0
      UniProtKB/TrEMBL
      Q3U6L3
      Related
      ENSMUSP00000022082.7, OTTMUSP00000022985, ENSMUST00000022082.7, OTTMUST00000049564
      Conserved Domains (1) summary
      TIGR02180
      Location:1599
      GRX_euk; Glutaredoxin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      75839873..75850151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517477.1XP_006517540.1  glutaredoxin-1 isoform X1

      See identical proteins and their annotated locations for XP_006517540.1

      UniProtKB/Swiss-Prot
      Q9QUH0
      UniProtKB/TrEMBL
      Q3U6L3
      Conserved Domains (1) summary
      TIGR02180
      Location:1599
      GRX_euk; Glutaredoxin
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