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    SPRY2 sprouty RTK signaling antagonist 2 [ Homo sapiens (human) ]

    Gene ID: 10253, updated on 22-Apr-2017
    Official Symbol
    SPRY2provided by HGNC
    Official Full Name
    sprouty RTK signaling antagonist 2provided by HGNC
    Primary source
    HGNC:HGNC:11270
    See related
    Ensembl:ENSG00000136158 MIM:602466; Vega:OTTHUMG00000017140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IGAN3; hSPRY2
    Summary
    This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    13q31.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 13 NC_000013.11 (80335976..80341115, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (80910111..80915086, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370275 Neighboring gene uncharacterized LOC101927238 Neighboring gene uncharacterized LOC105370276 Neighboring gene RNA, U6 small nuclear 61, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    IgA nephropathy, susceptibility to, 3
    MedGen: CN235210 OMIM: 616818 GeneReviews: Not available
    not available

    NHGRI GWAS Catalog

    Description
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    NHGRI GWA Catalog
    Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
    NHGRI GWA Catalog
    Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.
    NHGRI GWA Catalog
    Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.
    NHGRI GWA Catalog
    Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
    NHGRI GWA Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    NHGRI GWA Catalog
    Identification of new genetic risk variants for type 2 diabetes.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef SPRY2 upregulation inhibits HIV-1 Gag-, Nef-, and Tat-specific T cell polyfunctionality independently of the PD-1 pathway PubMed
    Pr55(Gag) gag SPRY2 upregulation inhibits HIV-1 Gag-, Nef-, and Tat-specific T cell polyfunctionality independently of the PD-1 pathway PubMed
    gag SPRY2 interactions with PI(4,5)P2 and PLCgamma allow it to influence HIV-1 Gag release through interference with PI(4,5)P2 dynamics PubMed
    gag SPRY-mediated inhibition of HIV-1 Gag release is repressed by IP3R PubMed
    gag SPRY2 associates with ESCR-II component EAP20 to promote HIV-1 Gag release PubMed
    Tat tat SPRY2 upregulation inhibits HIV-1 Gag-, Nef-, and Tat-specific T cell polyfunctionality independently of the PD-1 pathway PubMed
    tat The expression of SPRY2 gene is upregulated in both Jurkat-Tat101 and Jurkat-Tat72 cells PubMed

    Go to the HIV-1, Human Interaction Database

    • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
    • EGFR downregulation, organism-specific biosystem (from REACTOME)
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    • Ectoderm Differentiation, organism-specific biosystem (from WikiPathways)
      Ectoderm Differentiation, organism-specific biosystemModel depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
    • FGF signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FGF signaling pathway, organism-specific biosystem
      FGF signaling pathway
    • Internalization of ErbB1, organism-specific biosystem (from Pathway Interaction Database)
      Internalization of ErbB1, organism-specific biosystem
      Internalization of ErbB1
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • Negative regulation of FGFR1 signaling, organism-specific biosystem (from REACTOME)
      Negative regulation of FGFR1 signaling, organism-specific biosystemOnce activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-m...
    • Negative regulation of FGFR2 signaling, organism-specific biosystem (from REACTOME)
      Negative regulation of FGFR2 signaling, organism-specific biosystemOnce activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-m...
    • Negative regulation of FGFR3 signaling, organism-specific biosystem (from REACTOME)
      Negative regulation of FGFR3 signaling, organism-specific biosystemOnce activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-m...
    • Negative regulation of FGFR4 signaling, organism-specific biosystem (from REACTOME)
      Negative regulation of FGFR4 signaling, organism-specific biosystemOnce activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-m...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling Pathways in Glioblastoma, organism-specific biosystem (from WikiPathways)
      Signaling Pathways in Glioblastoma, organism-specific biosystemThe most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core p...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR1, organism-specific biosystem (from REACTOME)
      Signaling by FGFR1, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
      Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR3, organism-specific biosystem (from REACTOME)
      Signaling by FGFR3, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR4, organism-specific biosystem (from REACTOME)
      Signaling by FGFR4, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by PTP1B, organism-specific biosystem
      Signaling events mediated by PTP1B
    • Spry regulation of FGF signaling, organism-specific biosystem (from REACTOME)
      Spry regulation of FGF signaling, organism-specific biosystemSprouty was initially characterized as a negative regulator of FGFR signaling in Drosophila. Human cells contain four genes encoding Sprouty proteins, of which Spry2 is the best studied and most wid...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC23039

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein serine/threonine kinase inhibitor activity IC
    Inferred by Curator
    more info
    PubMed 
    Process Evidence Code Pubs
    bud elongation involved in lung branching IEA
    Inferred from Electronic Annotation
    more info
     
    cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of mitotic spindle orientation IEA
    Inferred from Electronic Annotation
    more info
     
    inner ear morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    lung growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell projection organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    negative regulation of fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neurotrophin TRK receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050650.1 RefSeqGene

      Range
      5001..10140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318536.1NP_001305465.1  protein sprouty homolog 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Transcript variants 1-4 encode the same protein.
      Source sequence(s)
      AK313810, BC015745
      Consensus CDS
      CCDS9463.1
      UniProtKB/Swiss-Prot
      O43597
      Conserved Domains (1) summary
      pfam05210
      Location:184280
      Sprouty; Sprouty protein (Spry)
    2. NM_001318537.1NP_001305466.1  protein sprouty homolog 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Transcript variants 1-4 encode the same protein.
      Source sequence(s)
      AL713749, BC015745, DA230586
      Consensus CDS
      CCDS9463.1
      UniProtKB/Swiss-Prot
      O43597
      Related
      ENSP00000366306.1, OTTHUMP00000018544, ENST00000377102.5, OTTHUMT00000045387
      Conserved Domains (1) summary
      pfam05210
      Location:184280
      Sprouty; Sprouty protein (Spry)
    3. NM_001318538.1NP_001305467.1  protein sprouty homolog 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Transcript variants 1-4 encode the same protein.
      Source sequence(s)
      AL713749, BC015745, DA160975, DA230586
      Consensus CDS
      CCDS9463.1
      UniProtKB/Swiss-Prot
      O43597
      Conserved Domains (1) summary
      pfam05210
      Location:184280
      Sprouty; Sprouty protein (Spry)
    4. NM_005842.3NP_005833.1  protein sprouty homolog 2

      See identical proteins and their annotated locations for NP_005833.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Transcript variants 1-4 encode the same protein.
      Source sequence(s)
      BC015745, CX866409
      Consensus CDS
      CCDS9463.1
      UniProtKB/Swiss-Prot
      O43597
      Related
      ENSP00000366308.3, OTTHUMP00000018543, ENST00000377104.3, OTTHUMT00000045386
      Conserved Domains (1) summary
      pfam05210
      Location:184280
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p7 Primary Assembly

      Range
      80335976..80341115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018924.2 Alternate CHM1_1.1

      Range
      80877733..80882872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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