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    TAF10 TATA-box binding protein associated factor 10 [ Homo sapiens (human) ]

    Gene ID: 6881, updated on 8-Apr-2018
    Official Symbol
    TAF10provided by HGNC
    Official Full Name
    TATA-box binding protein associated factor 10provided by HGNC
    Primary source
    HGNC:HGNC:11543
    See related
    Ensembl:ENSG00000166337 MIM:600475; Vega:OTTHUMG00000133402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAF2A; TAF2H; TAFII30
    Summary
    Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in spleen (RPKM 44.4), testis (RPKM 44.3) and 25 other tissues See more
    Orthologs
    Location:
    11p15.4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (6610817..6612244, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6632048..6633475, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene dynein heavy chain domain 1 Neighboring gene ribosomal RNA processing 8 Neighboring gene uncharacterized LOC107984305 Neighboring gene integrin linked kinase Neighboring gene tripeptidyl peptidase 1 Neighboring gene dachsous cadherin-related 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
    tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
    tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
    tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
    tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    estrogen receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitinyl hydrolase activity TAS
    Traceable Author Statement
    more info
     
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA-templated transcription, initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription by RNA polymerase II IC
    Inferred by Curator
    more info
    PubMed 
    transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
     
    transcription elongation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    transcription initiation from RNA polymerase II promoter IC
    Inferred by Curator
    more info
    PubMed 
    transcription initiation from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    PCAF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    STAGA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor TFTC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    transcription initiation factor TFIID subunit 10
    Names
    STAF28
    TAF(II)30
    TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
    TAFII-30
    TATA box binding protein (TBP)-associated factor, RNA polymerase II, H, 30kD
    transcription initiation factor TFIID 30 kD subunit
    transcription initiation factor TFIID 30 kDa subunit

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006284.3NP_006275.1  transcription initiation factor TFIID subunit 10

      See identical proteins and their annotated locations for NP_006275.1

      Status: REVIEWED

      Source sequence(s)
      AC091564, BM990572
      Consensus CDS
      CCDS7769.1
      UniProtKB/Swiss-Prot
      Q12962
      Related
      ENSP00000299424.4, OTTHUMP00000164586, ENST00000299424.8, OTTHUMT00000257259
      Conserved Domains (1) summary
      cd07982
      Location:115217
      TAF10; The TATA Binding Protein (TBP) Associated Factor 10

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      6610817..6612244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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