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    Anxa2 annexin A2 [ Mus musculus (house mouse) ]

    Gene ID: 12306, updated on 23-Apr-2017
    Official Symbol
    Anxa2provided by MGI
    Official Full Name
    annexin A2provided by MGI
    Primary source
    MGI:MGI:88246
    See related
    Ensembl:ENSMUSG00000032231 Vega:OTTMUSG00000030907
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cal1h; AW215814
    Orthologs
    Location:
    9 C; 9 38.58 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (69453683..69491792)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (69301490..69339592)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene purine-nucleoside phosphorylase pseudogene Neighboring gene ribosomal protein L7A pseudogene Neighboring gene microRNA 3109 Neighboring gene predicted gene, 31469 Neighboring gene forkhead box B1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rab GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding involved in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipase A2 inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to receptor activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    body fluid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    catabolism by host of symbiont protein ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to acid chemical IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen fibril organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibrinolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane budding ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation by host of symbiont molecular function ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of development of symbiont involved in interaction with host ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of low-density lipoprotein particle receptor catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of low-density lipoprotein particle receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    osteoclast development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of low-density lipoprotein particle clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of low-density lipoprotein particle receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of low-density lipoprotein receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of low-density lipoprotein receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor recycling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor-mediated endocytosis involved in cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of receptor-mediated endocytosis involved in cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vacuole organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein targeting to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    PCSK9-AnxA2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    Schmidt-Lanterman incisure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basement membrane IEA
    Inferred from Electronic Annotation
    more info
     
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lipid particle ISO
    Inferred from Sequence Orthology
    more info
     
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    macropinosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath adaxonal region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress fiber ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    annexin A2
    Names
    33-kDa calcimedin
    33-kDa lymphocyte Ca<2+>- binding protein
    33kDa lymphocyte Ca<2+>- binding protein
    36-kDa calelectrin
    PAP-IV
    annexin II
    annexin-2
    calpactin I heavy chain
    calpactin-1 heavy chain
    chromobindin-8
    lipocortin II
    p36
    placental anticoagulant protein IV
    protein I

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007585.3NP_031611.1  annexin A2

      See identical proteins and their annotated locations for NP_031611.1

      Status: PROVISIONAL

      Source sequence(s)
      CT009708
      Consensus CDS
      CCDS23316.1
      UniProtKB/Swiss-Prot
      P07356
      UniProtKB/TrEMBL
      Q542G9
      Related
      ENSMUSP00000034756.8, OTTMUSP00000040269, ENSMUST00000034756.14, OTTMUST00000076481
      Conserved Domains (1) summary
      pfam00191
      Location:109174
      Annexin; Annexin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      69453683..69491792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510796.2XP_006510859.1  annexin A2 isoform X1

      See identical proteins and their annotated locations for XP_006510859.1

      UniProtKB/Swiss-Prot
      P07356
      UniProtKB/TrEMBL
      Q542G9
      Conserved Domains (1) summary
      pfam00191
      Location:109174
      Annexin; Annexin
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