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    Il13ra2 interleukin 13 receptor, alpha 2 [ Mus musculus (house mouse) ]

    Gene ID: 16165, updated on 12-Mar-2017
    Official Symbol
    Il13ra2provided by MGI
    Official Full Name
    interleukin 13 receptor, alpha 2provided by MGI
    Primary source
    MGI:MGI:1277954
    See related
    Ensembl:ENSMUSG00000031289 Vega:OTTMUSG00000018962
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD213a2; IL-13R-alpha-2
    Summary
    This gene encodes a receptor protein that binds to interleukin 13 (IL-13) with very high affinity. The encoded protein acts as a decoy receptor, and does not elicit any signal upon the binding of IL-13. Mice lacking the encoded protein exhibit increased levels of serum immunoglobulins, immune-dependent production of interferon gamma and, increased bone marrow macrophage progenitor frequency. Macrophages lacking the encoded protein release less nitric oxide and IL-12 in response to lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
    Orthologs
    Location:
    X F2; X 68.46 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (147383478..147429192, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (143818021..143838375, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 2C Neighboring gene microRNA 1298 Neighboring gene microRNA 448 Neighboring gene vomeronasal 1 receptor 239, pseudogene Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    immunoglobulin mediated immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    interleukin-13 receptor subunit alpha-2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306059.1NP_001292988.1  interleukin-13 receptor subunit alpha-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001292988.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL662932, AL807780, BX005200
      UniProtKB/Swiss-Prot
      O88786
      Conserved Domains (1) summary
      pfam09240
      Location:134229
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    2. NM_008356.4NP_032382.1  interleukin-13 receptor subunit alpha-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032382.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL662932, AL807780, BX005200
      Consensus CDS
      CCDS30460.1
      UniProtKB/Swiss-Prot
      O88786
      Related
      ENSMUSP00000033646, OTTMUSP00000020481, ENSMUST00000033646, OTTMUST00000045547
      Conserved Domains (1) summary
      pfam09240
      Location:134229
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      147383478..147429192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528707.3XP_006528770.1  interleukin-13 receptor subunit alpha-2 isoform X1

      See identical proteins and their annotated locations for XP_006528770.1

      UniProtKB/Swiss-Prot
      O88786
      Related
      ENSMUSP00000108446, ENSMUST00000112827
      Conserved Domains (1) summary
      pfam09240
      Location:134229
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    2. XM_017318395.1XP_017173884.1  interleukin-13 receptor subunit alpha-2 isoform X2

      UniProtKB/Swiss-Prot
      O88786
      Conserved Domains (1) summary
      pfam09240
      Location:134229
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    3. XM_006528708.3XP_006528771.1  interleukin-13 receptor subunit alpha-2 isoform X1

      See identical proteins and their annotated locations for XP_006528771.1

      UniProtKB/Swiss-Prot
      O88786
      Conserved Domains (1) summary
      pfam09240
      Location:134229
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
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