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    Wnk1 WNK lysine deficient protein kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 232341, updated on 3-Sep-2017
    Official Symbol
    Wnk1provided by MGI
    Official Full Name
    WNK lysine deficient protein kinase 1provided by MGI
    Primary source
    MGI:MGI:2442092
    See related
    Ensembl:ENSMUSG00000045962 Vega:OTTMUSG00000031633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hsn2; Prkwnk1; EG406236; mKIAA0344; 6430573H23Rik
    Orthologs
    Location:
    6; 6 F1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (119923969..120038679, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (119873987..119988673, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 76, member A pseudogene Neighboring gene RAD52 homolog, DNA repair protein Neighboring gene microRNA 706 Neighboring gene ninjurin 2 Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 3

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC175896, MGC175898

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    chloride channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    potassium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of pancreatic juice secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cellular process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction by trans-phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    serine/threonine-protein kinase WNK1
    Names
    protein kinase lysine-deficient 1
    protein kinase with no lysine 1
    NP_001171949.1
    NP_001171950.1
    NP_001186012.1
    NP_001186013.1
    NP_941992.2
    XP_011239622.1
    XP_017177031.1
    XP_017177032.1
    XP_017177033.1
    XP_017177034.1
    XP_017177035.1
    XP_017177036.1
    XP_017177037.1
    XP_017177038.1
    XP_017177039.1
    XP_017177041.1
    XP_017177042.1
    XP_017177043.1
    XP_017177044.1
    XP_017177045.1
    XP_017177046.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185020.1NP_001171949.1  serine/threonine-protein kinase WNK1 isoform 2

      See identical proteins and their annotated locations for NP_001171949.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame compared to variant 5. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 5.
      Source sequence(s)
      AK133738, BC056761, BC138445
      Consensus CDS
      CCDS85147.1
      UniProtKB/Swiss-Prot
      P83741
      Related
      ENSMUSP00000145304.1, OTTMUSP00000073491, ENSMUST00000203030.2, OTTMUST00000140147
      Conserved Domains (3) summary
      smart00220
      Location:226479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    2. NM_001185021.1NP_001171950.1  serine/threonine-protein kinase WNK1 isoform 3

      See identical proteins and their annotated locations for NP_001171950.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame compared to variant 5. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 5.
      Source sequence(s)
      AK133738, BC056761, BC145282
      Consensus CDS
      CCDS51888.1
      UniProtKB/Swiss-Prot
      P83741
      Related
      ENSMUSP00000086019.5, OTTMUSP00000073490, ENSMUST00000088646.11, OTTMUST00000140146
      Conserved Domains (3) summary
      smart00220
      Location:226479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    3. NM_001199083.1NP_001186012.1  serine/threonine-protein kinase WNK1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame compared to variant 5. This variant represents the exon combination of the brain and spinal cord variant described in Figure 2F of PubMed ID 18521183. This variant encodes isoform 4, which is shorter than isoform 5 but has the same N- and C-termini.
      Source sequence(s)
      AC113092, AK133738, BC054836, BC171955, CN693598
      Consensus CDS
      CCDS57445.1
      UniProtKB/Swiss-Prot
      P83741
      UniProtKB/TrEMBL
      Q7TPR2
      Related
      ENSMUSP00000136777.1, ENSMUST00000177761.7
      Conserved Domains (3) summary
      smart00220
      Location:226479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    4. NM_001199084.1NP_001186013.1  serine/threonine-protein kinase WNK1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5). This variant represents the exon combination of the dorsal root ganglia and sciatic nerve variant described in Figure 2F of PubMed ID 18521183.
      Source sequence(s)
      AC113092, AK133738, BC054836, BC145282, BC171955, CN693598
      Consensus CDS
      CCDS57444.1
      UniProtKB/Swiss-Prot
      P83741
      UniProtKB/TrEMBL
      Q7TPR2
      Related
      ENSMUSP00000086017.6, ENSMUST00000088644.12
      Conserved Domains (3) summary
      smart00220
      Location:226479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    5. NM_198703.3NP_941992.2  serine/threonine-protein kinase WNK1 isoform 1

      See identical proteins and their annotated locations for NP_941992.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has multiple differences in the coding region but maintains the reading frame compared to variant 5. The resulting protein (isoform 1) is shorter but has the same N- and C-termini compared to isoform 5.
      Source sequence(s)
      AK133738, AY309076, BC056761, BC171955
      Consensus CDS
      CCDS20478.1
      UniProtKB/Swiss-Prot
      P83741
      Related
      ENSMUSP00000063001.6, OTTMUSP00000041662, ENSMUST00000060043.12, OTTMUST00000078356
      Conserved Domains (3) summary
      smart00220
      Location:226479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      119923969..120038679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321542.1XP_017177031.1  serine/threonine-protein kinase WNK1 isoform X1

    2. XM_017321556.1XP_017177045.1  serine/threonine-protein kinase WNK1 isoform X15

    3. XM_011241320.2XP_011239622.1  serine/threonine-protein kinase WNK1 isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:226479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    4. XM_017321557.1XP_017177046.1  serine/threonine-protein kinase WNK1 isoform X16

      UniProtKB/Swiss-Prot
      P83741
      Conserved Domains (3) summary
      smart00220
      Location:226479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    5. XM_017321555.1XP_017177044.1  serine/threonine-protein kinase WNK1 isoform X14

    6. XM_017321554.1XP_017177043.1  serine/threonine-protein kinase WNK1 isoform X13

      UniProtKB/Swiss-Prot
      P83741
      Conserved Domains (3) summary
      smart00220
      Location:226479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    7. XM_017321553.1XP_017177042.1  serine/threonine-protein kinase WNK1 isoform X12

    8. XM_017321552.1XP_017177041.1  serine/threonine-protein kinase WNK1 isoform X11

    9. XM_017321550.1XP_017177039.1  serine/threonine-protein kinase WNK1 isoform X10

    10. XM_017321546.1XP_017177035.1  serine/threonine-protein kinase WNK1 isoform X6

    11. XM_017321549.1XP_017177038.1  serine/threonine-protein kinase WNK1 isoform X9

      UniProtKB/Swiss-Prot
      P83741
      Conserved Domains (3) summary
      smart00220
      Location:226479
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14030
      Location:195483
      STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
      pfam12202
      Location:500537
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    12. XM_017321548.1XP_017177037.1  serine/threonine-protein kinase WNK1 isoform X8

    13. XM_017321547.1XP_017177036.1  serine/threonine-protein kinase WNK1 isoform X7

    14. XM_017321545.1XP_017177034.1  serine/threonine-protein kinase WNK1 isoform X5

    15. XM_017321543.1XP_017177032.1  serine/threonine-protein kinase WNK1 isoform X3

    16. XM_017321544.1XP_017177033.1  serine/threonine-protein kinase WNK1 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037155.1: Suppressed sequence

      Description
      NM_001037155.1: This RefSeq was permanently suppressed because it represents a nervous system-specific exon of WNK1, GeneID 232341, but there currently is insufficient support for a transcript containing this exon.
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