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    Lpin1 lipin 1 [ Mus musculus (house mouse) ]

    Gene ID: 14245, updated on 6-Aug-2017
    Official Symbol
    Lpin1provided by MGI
    Official Full Name
    lipin 1provided by MGI
    Primary source
    MGI:MGI:1891340
    See related
    Ensembl:ENSMUSG00000020593
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    fld; Lipin1; Kiaa0188; mKIAA0188; 4631420P06
    Orthologs
    Location:
    12 A1.1; 12 7.9 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (16535669..16646969, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (16542475..16596576, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L11 pseudogene Neighboring gene predicted gene, 36372 Neighboring gene neurotensin receptor 2 Neighboring gene gene regulated by estrogen in breast cancer protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase II transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peroxisome proliferator activated receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phosphatidate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    fat cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    fatty acid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial fission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of histone deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    triglyceride mobilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    phosphatidate phosphatase LPIN1
    Names
    fatty liver dystrophy protein
    NP_001123884.1
    NP_056578.2
    NP_766538.2
    XP_006515038.1
    XP_006515039.1
    XP_006515040.1
    XP_006515041.1
    XP_006515045.1
    XP_006515046.1
    XP_006515047.1
    XP_006515049.1
    XP_006515050.1
    XP_006515051.1
    XP_011242117.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130412.1NP_001123884.1  phosphatidate phosphatase LPIN1 isoform a

      See identical proteins and their annotated locations for NP_001123884.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant differs in the 5' UTR, compared to variant 1. This variant encodes isoform a. Isoform a is also known as isoform alpha. Variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AK009789, AK014526, AK030921, BY127780, BY209929, CK621866, CX205142
      Consensus CDS
      CCDS25823.1
      UniProtKB/Swiss-Prot
      Q91ZP3
      UniProtKB/TrEMBL
      E9QKQ5, Q8CD95
      Related
      ENSMUSP00000152276.1, ENSMUST00000222989.1
      Conserved Domains (4) summary
      pfam15017
      Location:856885
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:627852
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:465555
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    2. NM_015763.4NP_056578.2  phosphatidate phosphatase LPIN1 isoform b

      See identical proteins and their annotated locations for NP_056578.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a longer protein (isoform b), compared to isoform a. Isoform b is also known as isoform beta.
      Source sequence(s)
      AK009789, AK014526, BY127780, CK621866, CX205142
      Consensus CDS
      CCDS25822.1
      UniProtKB/Swiss-Prot
      Q91ZP3
      UniProtKB/TrEMBL
      A0A0R4J0V3
      Related
      ENSMUSP00000070583.5, ENSMUST00000067124.5
      Conserved Domains (4) summary
      pfam15017
      Location:889918
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:660885
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:498588
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    3. NM_172950.3NP_766538.2  phosphatidate phosphatase LPIN1 isoform a

      See identical proteins and their annotated locations for NP_766538.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a). Isoform a is also known as isoform alpha. Variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AK009789, AK014526, AK030921, BY127780, CK621866, CX205142
      Consensus CDS
      CCDS25823.1
      UniProtKB/Swiss-Prot
      Q91ZP3
      UniProtKB/TrEMBL
      E9QKQ5, Q8CD95
      Related
      ENSMUSP00000152466.1, ENSMUST00000221230.1
      Conserved Domains (4) summary
      pfam15017
      Location:856885
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:627852
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:465555
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      16535669..16646969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514975.3XP_006515038.1  phosphatidate phosphatase LPIN1 isoform X1

      Conserved Domains (4) summary
      pfam15017
      Location:9751004
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:61166
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:746971
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:558674
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    2. XM_006514977.3XP_006515040.1  phosphatidate phosphatase LPIN1 isoform X3

      Conserved Domains (4) summary
      pfam15017
      Location:949978
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:61166
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:720945
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:558648
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    3. XM_006514988.3XP_006515051.1  phosphatidate phosphatase LPIN1 isoform X8

      See identical proteins and their annotated locations for XP_006515051.1

      UniProtKB/Swiss-Prot
      Q91ZP3
      UniProtKB/TrEMBL
      A0A0R4J0V3
      Related
      ENSMUSP00000106696.3, ENSMUST00000111067.9
      Conserved Domains (4) summary
      pfam15017
      Location:889918
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:660885
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:498588
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    4. XM_006514978.3XP_006515041.1  phosphatidate phosphatase LPIN1 isoform X4

      Conserved Domains (4) summary
      pfam15017
      Location:942971
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:61166
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:713938
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:525641
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    5. XM_006514976.3XP_006515039.1  phosphatidate phosphatase LPIN1 isoform X2

      Conserved Domains (4) summary
      pfam15017
      Location:9741003
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:61166
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:745970
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:557673
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    6. XM_006514982.3XP_006515045.1  phosphatidate phosphatase LPIN1 isoform X5

      Conserved Domains (4) summary
      pfam15017
      Location:916945
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:61166
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:687912
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:525615
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    7. XM_006514987.3XP_006515050.1  phosphatidate phosphatase LPIN1 isoform X7

      Conserved Domains (4) summary
      pfam15017
      Location:914943
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:685910
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:497613
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    8. XM_006514983.3XP_006515046.1  phosphatidate phosphatase LPIN1 isoform X6

      See identical proteins and their annotated locations for XP_006515046.1

      Conserved Domains (4) summary
      pfam15017
      Location:915944
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:686911
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:498614
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    9. XM_006514984.3XP_006515047.1  phosphatidate phosphatase LPIN1 isoform X6

      See identical proteins and their annotated locations for XP_006515047.1

      Conserved Domains (4) summary
      pfam15017
      Location:915944
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:686911
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:498614
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    10. XM_011243815.2XP_011242117.1  phosphatidate phosphatase LPIN1 isoform X9

      Conserved Domains (3) summary
      pfam15017
      Location:734763
      AF1Q; Drug resistance and apoptosis regulator
      pfam08235
      Location:505730
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:317433
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    11. XM_006514986.3XP_006515049.1  phosphatidate phosphatase LPIN1 isoform X6

      See identical proteins and their annotated locations for XP_006515049.1

      Conserved Domains (4) summary
      pfam15017
      Location:915944
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:686911
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:498614
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
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