Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Park2 Parkinson disease (autosomal recessive, juvenile) 2, parkin [ Mus musculus (house mouse) ]

    Gene ID: 50873, updated on 13-Aug-2017
    Official Symbol
    Park2provided by MGI
    Official Full Name
    Parkinson disease (autosomal recessive, juvenile) 2, parkinprovided by MGI
    Primary source
    MGI:MGI:1355296
    See related
    Ensembl:ENSMUSG00000023826 Vega:OTTMUSG00000046340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PRKN
    Orthologs
    Location:
    17 A1; 17 7.8 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (10840359..12063370)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (11033250..12256227)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene PARK2 co-regulated Neighboring gene predicted gene 16168 Neighboring gene uncharacterized protein C3orf18 homolog pseudogene Neighboring gene predicted gene 16169 Neighboring gene predicted gene, 41526 Neighboring gene predicted gene, 41525 Neighboring gene DNA segment, Chr 17, ERATO Doi 648, expressed Neighboring gene predicted gene, 46604 Neighboring gene teratocarcinoma-derived growth factor, pseudogene 2 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Neighboring gene mitogen-activated protein kinase kinase kinase 4 Neighboring gene predicted gene, 46605

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC130518

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    F-box domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aggresome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to L-glutamate ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to toxic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine uptake involved in synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    free ubiquitin chain polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion localization ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    mitophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation by host of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glucokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intralumenal vesicle formation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oxidative stress-induced neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of primary amine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of spontaneous neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    norepinephrine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitophagy in response to mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurotransmitter uptake ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein linear polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein linear polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein K6-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrial membrane potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    startle response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with LUBAC complex ISO
    Inferred from Sequence Orthology
    more info
     
    Parkin-FBXW7-Cul1 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with mitochondrion-derived vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density of dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    E3 ubiquitin-protein ligase parkin
    Names
    parkin RBR E3 ubiquitin-protein ligase
    parkin protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317726.1NP_001304655.1  E3 ubiquitin-protein ligase parkin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter, and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC091254, AC091484, AC091777, AC093450, AC105305
      UniProtKB/Swiss-Prot
      Q9WVS6
      Conserved Domains (2) summary
      cd01798
      Location:372
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00213
      Location:172
      UBQ; Ubiquitin homologues
    2. NM_016694.4NP_057903.1  E3 ubiquitin-protein ligase parkin isoform 1

      See identical proteins and their annotated locations for NP_057903.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC091254, AC091484, AC091777, AC093450, AC105305, AC122259, AC163687, CT009575
      Consensus CDS
      CCDS79506.1
      UniProtKB/Swiss-Prot
      Q9WVS6
      Related
      ENSMUSP00000140587.1, OTTMUSP00000066774, ENSMUST00000191124.6, OTTMUST00000120776
      Conserved Domains (4) summary
      cd01798
      Location:372
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00213
      Location:172
      UBQ; Ubiquitin homologues
      smart00647
      Location:313374
      IBR; In Between Ring fingers
      pfam01485
      Location:412452
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      10840359..12063370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523336.3XP_006523399.1  E3 ubiquitin-protein ligase parkin isoform X1

      Conserved Domains (4) summary
      cd01798
      Location:372
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00213
      Location:172
      UBQ; Ubiquitin homologues
      smart00647
      Location:314375
      IBR; In Between Ring fingers
      pfam01485
      Location:413453
      IBR; IBR domain, a half RING-finger domain
    2. XM_017317572.1XP_017173061.1  E3 ubiquitin-protein ligase parkin isoform X2

    3. XM_017317575.1XP_017173064.1  E3 ubiquitin-protein ligase parkin isoform X6

      Related
      ENSMUSP00000151830.1, ENSMUST00000218435.1
    4. XM_017317574.1XP_017173063.1  E3 ubiquitin-protein ligase parkin isoform X5

    5. XM_006523339.2XP_006523402.1  E3 ubiquitin-protein ligase parkin isoform X7

      Conserved Domains (2) summary
      smart00647
      Location:123184
      IBR; In Between Ring fingers
      pfam01485
      Location:222262
      IBR; IBR domain, a half RING-finger domain
    6. XM_017317576.1XP_017173065.1  E3 ubiquitin-protein ligase parkin isoform X8

    7. XM_006523337.3XP_006523400.1  E3 ubiquitin-protein ligase parkin isoform X3

      Conserved Domains (2) summary
      smart00647
      Location:183244
      IBR; In Between Ring fingers
      pfam01485
      Location:282322
      IBR; IBR domain, a half RING-finger domain
    8. XM_017317573.1XP_017173062.1  E3 ubiquitin-protein ligase parkin isoform X4

    RNA

    1. XR_001782089.1 RNA Sequence

    2. XR_001782090.1 RNA Sequence

    Support Center