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    Cdh23 cadherin 23 (otocadherin) [ Mus musculus (house mouse) ]

    Gene ID: 22295, updated on 19-May-2018
    Official Symbol
    Cdh23provided by MGI
    Official Full Name
    cadherin 23 (otocadherin)provided by MGI
    Primary source
    MGI:MGI:1890219
    See related
    Ensembl:ENSMUSG00000012819 Vega:OTTMUSG00000017511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    v; ahl; bob; bus; ahl1; mdfw; sals; USH1D; nmf112; nmf181; nmf252; 4930542A03Rik
    Expression
    Biased expression in testis adult (RPKM 8.3), heart adult (RPKM 1.0) and 8 other tissues See more
    Orthologs
    See Cdh23 in Genome Data Viewer
    Location:
    10 B4; 10 30.11 cM
    Exon count:
    74
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (60302748..60696513, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (59766022..60159238, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene headcase homolog pseudogene Neighboring gene prosaposin Neighboring gene V-set immunoregulatory receptor Neighboring gene predicted gene, 17455 Neighboring gene solute carrier family 29 (nucleoside transporters), member 3 Neighboring gene unc-5 netrin receptor B

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
     
    auditory receptor cell stereocilium organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    auditory receptor cell stereocilium organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    equilibrioception ISO
    Inferred from Sequence Orthology
    more info
     
    homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    inner ear auditory receptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear receptor cell stereocilium organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    photoreceptor cell maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    righting reflex IMP
    Inferred from Mutant Phenotype
    more info
     
    sensory perception of light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of light stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of sound IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    kinocilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    stereocilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stereocilium tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    cadherin-23
    Names
    age related hearing loss 1
    bobby
    bustling
    modifier of deaf waddler
    otocadherin
    waltzer

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252635.1NP_001239564.1  cadherin-23 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC079082, AC079818, AC079819, AK016365
      Consensus CDS
      CCDS56704.1
      UniProtKB/TrEMBL
      K4DI74
      Related
      ENSMUSP00000101104.2, ENSMUST00000105464.8
      Conserved Domains (1) summary
      cd11304
      Location:15311628
      Cadherin_repeat; Cadherin tandem repeat domain
    2. NM_023370.3NP_075859.2  cadherin-23 isoform 1 precursor

      See identical proteins and their annotated locations for NP_075859.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC079082, AF308939, AK016365
      UniProtKB/Swiss-Prot
      Q99PF4
      Conserved Domains (1) summary
      cd11304
      Location:15331630
      Cadherin_repeat; Cadherin tandem repeat domain

    RNA

    1. NR_045556.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC079082, AC079818, AC079819, AK016365
      Related
      ENSMUST00000128249.7

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      60302748..60696513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313930.1XP_017169419.1  cadherin-23 isoform X4

      Related
      ENSMUSP00000072973.4, OTTMUSP00000019115, ENSMUST00000073242.10, OTTMUST00000042527
    2. XM_017313926.1XP_017169415.1  cadherin-23 isoform X1

      Conserved Domains (1) summary
      cd11304
      Location:15331630
      Cadherin_repeat; Cadherin tandem repeat domain
    3. XM_017313927.1XP_017169416.1  cadherin-23 isoform X1

      Related
      ENSMUSP00000101102.1, OTTMUSP00000019116, ENSMUST00000105462.7, OTTMUST00000042528
      Conserved Domains (1) summary
      cd11304
      Location:15331630
      Cadherin_repeat; Cadherin tandem repeat domain
    4. XM_017313929.1XP_017169418.1  cadherin-23 isoform X3

      UniProtKB/Swiss-Prot
      Q99PF4
      Conserved Domains (1) summary
      cd11304
      Location:166264
      Cadherin_repeat; Cadherin tandem repeat domain
    5. XM_006513602.2XP_006513665.1  cadherin-23 isoform X3

      See identical proteins and their annotated locations for XP_006513665.1

      UniProtKB/Swiss-Prot
      Q99PF4
      Conserved Domains (1) summary
      cd11304
      Location:166264
      Cadherin_repeat; Cadherin tandem repeat domain
    6. XM_017313931.1XP_017169420.1  cadherin-23 isoform X5

    7. XM_017313928.1XP_017169417.1  cadherin-23 isoform X2

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