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    Trpv1 transient receptor potential cation channel, subfamily V, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83810, updated on 25-Jun-2017
    Official Symbol
    Trpv1provided by RGD
    Official Full Name
    transient receptor potential cation channel, subfamily V, member 1provided by RGD
    Primary source
    RGD:628841
    See related
    Ensembl:ENSRNOG00000019486
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Vr1; Vr1l1; VR.5'sv; TRPV1_SON
    Summary
    ion channel that demonstrates heat-evoked membrane currents [RGD, Feb 2006]
    Orthologs
    Location:
    10q24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59799123..59824208)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (59538296..59563441)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene Tax1 binding protein 3 Neighboring gene cystinosin, lysosomal cystine transporter Neighboring gene sedoheptulokinase Neighboring gene transient receptor potential cation channel, subfamily V, member 3 Neighboring gene aspartoacylase Neighboring gene spermatogenesis associated 22

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-release channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chloride channel regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    excitatory extracellular ligand-gated ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular ligand-gated ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular ligand-gated ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    ligand-gated ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphoprotein binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    temperature-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    temperature-gated ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    behavioral response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral response to pain ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to ATP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to acidic pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to acidic pH ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to alkaloid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to nerve growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to temperature stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    detection of chemical stimulus involved in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    detection of chemical stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    detection of temperature stimulus involved in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    detection of temperature stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    detection of temperature stimulus involved in thermoception IEA
    Inferred from Electronic Annotation
    more info
     
    detection of temperature stimulus involved in thermoception ISO
    Inferred from Sequence Orthology
    more info
     
    diet induced thermogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    diet induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    fever generation IEA
    Inferred from Electronic Annotation
    more info
     
    fever generation ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    microglial cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of establishment of blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    peptide secretion IEA
    Inferred from Electronic Annotation
    more info
     
    peptide secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gastric acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of molecular function IEA
    Inferred from Electronic Annotation
    more info
     
    release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    response to capsazepine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to capsazepine ISO
    Inferred from Sequence Orthology
    more info
     
    response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    response to organonitrogen compound ISO
    Inferred from Sequence Orthology
    more info
     
    response to pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to pH IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to pH ISO
    Inferred from Sequence Orthology
    more info
     
    response to pain ISO
    Inferred from Sequence Orthology
    more info
     
    response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    smooth muscle contraction involved in micturition IEA
    Inferred from Electronic Annotation
    more info
     
    smooth muscle contraction involved in micturition ISO
    Inferred from Sequence Orthology
    more info
     
    temperature homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    thermoception ISO
    Inferred from Sequence Orthology
    more info
     
    urinary bladder smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine membrane IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic component of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    transient receptor potential cation channel subfamily V member 1
    Names
    OTRPC1
    capsaicin receptor
    deltaN-TRPV1
    osm-9-like TRP channel 1
    transient receptor potential vanilloid 1 supraoptic nucleus
    vanilloid receptor 1
    vanilloid receptor subtype 1
    vanilloid receptor type 1 like protein 1
    vanilloid type 1 receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031982.1NP_114188.1  transient receptor potential cation channel subfamily V member 1

      See identical proteins and their annotated locations for NP_114188.1

      Status: PROVISIONAL

      Source sequence(s)
      AF029310
      UniProtKB/Swiss-Prot
      O35433
      Related
      ENSRNOP00000026493.3, ENSRNOT00000026493.6
      Conserved Domains (3) summary
      cd00204
      Location:199353
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      TIGR00870
      Location:52824
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:201231
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      59799123..59824208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      56974294..56999462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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