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    Rtn4 reticulon 4 [ Mus musculus (house mouse) ]

    Gene ID: 68585, updated on 7-May-2017
    Official Symbol
    Rtn4provided by MGI
    Official Full Name
    reticulon 4provided by MGI
    Primary source
    MGI:MGI:1915835
    See related
    Ensembl:ENSMUSG00000020458 Vega:OTTMUSG00000005336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ASY; NgA; NOGO; NSP-CL; Nogo-A; Nogo-B; Nogo-C; AA407876; AA409940; AA960376; mKIAA0886; mKIAA4153; 1110020G17Rik; C130026I10Rik
    Orthologs
    Location:
    11; 11 A3.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (29692898..29744414)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (29592898..29644414)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene 12092 Neighboring gene apurinic/apyrimidinic endonuclease 2 pseudogene Neighboring gene echinoderm microtubule associated protein like 6 Neighboring gene RIKEN cDNA 4931440F15 gene Neighboring gene predicted gene, 39671

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA4153

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonal fasciculation ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex radial glia guided migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endoplasmic reticulum tubular network formation ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron projection regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERBB3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mammary gland epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of branching morphogenesis of a nerve IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of branching morphogenesis of a nerve ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    reticulon-4
    Names
    neurite outgrowth inhibitor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024226.4NP_077188.1  reticulon-4 isoform C

      See identical proteins and their annotated locations for NP_077188.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a different segment for its 5' end, compared to variant 1. The resulting protein (isoform C) has a shorter and distinct N-terminus when it is compared to isoform A.
      Source sequence(s)
      AK034902, BU698622, BU848611, BY251875
      Consensus CDS
      CCDS24503.1
      UniProtKB/Swiss-Prot
      Q99P72
      UniProtKB/TrEMBL
      Q78NS1
      Related
      ENSMUSP00000053754.4, OTTMUSP00000005513, ENSMUST00000060992.5, OTTMUST00000011905
      Conserved Domains (1) summary
      pfam02453
      Location:12176
      Reticulon; Reticulon
    2. NM_194051.3NP_918940.1  reticulon-4 isoform D

      See identical proteins and their annotated locations for NP_918940.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses a different segment for its 5' end, compared to variant 1. The resulting protein (isoform D) has a shorter and distinct N-terminus when it is compared to isoform A.
      Source sequence(s)
      AK034902, AL929371, BC032272, BU698622
      Consensus CDS
      CCDS24502.1
      UniProtKB/Swiss-Prot
      Q99P72
      Related
      ENSMUSP00000099905.1, OTTMUSP00000005512, ENSMUST00000102841.7, OTTMUST00000011904
      Conserved Domains (1) summary
      pfam02453
      Location:8591023
      Reticulon; Reticulon
    3. NM_194052.3NP_918941.1  reticulon-4 isoform B1

      See identical proteins and their annotated locations for NP_918941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks one alternate exon in the coding region, compared to variant 1. The resulting protein (isoform B1) is shorter when it is compared to isoform A.
      Source sequence(s)
      AK034902, AL929371, BU698622
      Consensus CDS
      CCDS24499.1
      UniProtKB/TrEMBL
      Q8BH78
      Related
      ENSMUSP00000077875.4, OTTMUSP00000005511, ENSMUST00000078830.10, OTTMUST00000011903
      Conserved Domains (1) summary
      pfam02453
      Location:169333
      Reticulon; Reticulon
    4. NM_194053.3NP_918942.1  reticulon-4 isoform B2

      See identical proteins and their annotated locations for NP_918942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons in the coding region, compared to variant 1. The resulting protein (isoform B2) is shorter when it is compared to isoform A.
      Source sequence(s)
      AK034902, AL929371, BU698622
      Consensus CDS
      CCDS24500.1
      UniProtKB/TrEMBL
      Q8BHF5
      Related
      ENSMUSP00000099906.3, OTTMUSP00000005510, ENSMUST00000102842.9, OTTMUST00000011902
      Conserved Domains (1) summary
      pfam02453
      Location:188352
      Reticulon; Reticulon
    5. NM_194054.3NP_918943.1  reticulon-4 isoform A

      See identical proteins and their annotated locations for NP_918943.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform A).
      Source sequence(s)
      AK034902, AL929371, BC032272, BU698622
      Consensus CDS
      CCDS24501.1
      UniProtKB/Swiss-Prot
      Q99P72
      Related
      ENSMUSP00000099907.3, OTTMUSP00000005509, ENSMUST00000102843.9, OTTMUST00000011901
      Conserved Domains (1) summary
      pfam02453
      Location:9751139
      Reticulon; Reticulon

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      29692898..29744414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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