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    MTA3 metastasis associated 1 family member 3 [ Homo sapiens (human) ]

    Gene ID: 57504, updated on 22-Apr-2017
    Official Symbol
    MTA3provided by HGNC
    Official Full Name
    metastasis associated 1 family member 3provided by HGNC
    Primary source
    HGNC:HGNC:23784
    See related
    Ensembl:ENSG00000057935 MIM:609050; Vega:OTTHUMG00000150452
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Orthologs
    Location:
    2p21
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (42494569..42795032)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (42721709..43011080)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel modifier subfamily G member 3 Neighboring gene voltage dependent anion channel 1 pseudogene 13 Neighboring gene ribosomal protein S13 pseudogene 3 Neighboring gene uncharacterized LOC105374555 Neighboring gene RNA, U6 small nuclear 137, pseudogene Neighboring gene oxoeicosanoid receptor 1 Neighboring gene uncharacterized LOC107985875 Neighboring gene 3-hydroxyanthranilate 3,4-dioxygenase Neighboring gene transfer RNA-Ile (TAT) 2-1 Neighboring gene fat mass and obesity associated pseudogene 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA1266

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    histone deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    metastasis-associated protein MTA3
    Names
    metastasis associated gene family, member 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282755.1NP_001269684.1  metastasis-associated protein MTA3 isoform a

      See identical proteins and their annotated locations for NP_001269684.1

      Status: VALIDATED

      Source sequence(s)
      AB033092, AK127245, AW292870, DA239202
      Consensus CDS
      CCDS62900.1
      UniProtKB/Swiss-Prot
      Q9BTC8
      UniProtKB/TrEMBL
      D6W5A2
      Related
      ENSP00000383973.1, OTTHUMP00000197388, ENST00000405592.5, OTTHUMT00000318147
      Conserved Domains (6) summary
      smart00717
      Location:213260
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:214259
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:319368
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:321369
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam01448
      Location:94145
      ELM2; ELM2 domain
      cl02608
      Location:2114
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
    2. NM_001282756.1NP_001269685.1  metastasis-associated protein MTA3 isoform a

      See identical proteins and their annotated locations for NP_001269685.1

      Status: VALIDATED

      Source sequence(s)
      AB033092, AW292870
      Consensus CDS
      CCDS62900.1
      UniProtKB/Swiss-Prot
      Q9BTC8
      UniProtKB/TrEMBL
      D6W5A2
      Related
      ENSP00000384249.1, OTTHUMP00000197384, ENST00000406652.5, OTTHUMT00000318143
      Conserved Domains (6) summary
      smart00717
      Location:213260
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:214259
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:319368
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:321369
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam01448
      Location:94145
      ELM2; ELM2 domain
      cl02608
      Location:2114
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
    3. NM_001330442.1NP_001317371.1  metastasis-associated protein MTA3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (c).
      Source sequence(s)
      AC025750, AC074375, AC098824
      Consensus CDS
      CCDS82441.1
      UniProtKB/Swiss-Prot
      Q9BTC8
    4. NM_001330443.1NP_001317372.1  metastasis-associated protein MTA3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC025750, AC074375, AC098824
      Conserved Domains (6) summary
      smart00717
      Location:269316
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:270315
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:375424
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:377425
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:3170
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:150201
      ELM2; ELM2 domain
    5. NM_001330444.1NP_001317373.1  metastasis-associated protein MTA3 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC025750, AC074375, AC098824
    6. NM_020744.3NP_065795.1  metastasis-associated protein MTA3 isoform b

      See identical proteins and their annotated locations for NP_065795.1

      Status: VALIDATED

      Source sequence(s)
      AC025750, BC053631, BU859486, CA447673, DB335600
      Consensus CDS
      CCDS46267.1
      UniProtKB/Swiss-Prot
      Q9BTC8
      Related
      ENSP00000385045.3, OTTHUMP00000197385, ENST00000407270.7, OTTHUMT00000318144
      Conserved Domains (6) summary
      smart00717
      Location:269316
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:270315
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:376425
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:378426
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:3170
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:150201
      ELM2; ELM2 domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      42494569..42795032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264459.2XP_005264516.1  metastasis-associated protein MTA3 isoform X3

      See identical proteins and their annotated locations for XP_005264516.1

      Conserved Domains (6) summary
      smart00717
      Location:213260
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:214259
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:320369
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:322370
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam01448
      Location:94145
      ELM2; ELM2 domain
      cl02608
      Location:2114
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
    2. XM_005264456.2XP_005264513.1  metastasis-associated protein MTA3 isoform X1

      Related
      ENSP00000385823.1, OTTHUMP00000197391, ENST00000405094.1, OTTHUMT00000318159
      Conserved Domains (6) summary
      smart00717
      Location:269316
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:270315
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:376425
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:378426
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:3170
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:150201
      ELM2; ELM2 domain
    3. XM_005264458.2XP_005264515.1  metastasis-associated protein MTA3 isoform X2

      Related
      ENSP00000386763.1, OTTHUMP00000202136, ENST00000409019.5, OTTHUMT00000327194
      Conserved Domains (6) summary
      smart00717
      Location:269316
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:270315
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:375424
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:377425
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:3170
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:150201
      ELM2; ELM2 domain
    4. XM_017004561.1XP_016860050.1  metastasis-associated protein MTA3 isoform X4

    5. XM_017004562.1XP_016860051.1  metastasis-associated protein MTA3 isoform X5

      Related
      ENSP00000391455.1, OTTHUMP00000197387, ENST00000454356.5, OTTHUMT00000318146

    RNA

    1. XR_939697.2 RNA Sequence

    2. XR_001738859.1 RNA Sequence

    3. XR_001738860.1 RNA Sequence

    4. XR_001738861.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      42651119..42913421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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