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    Ica1 islet cell autoantigen 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81024, updated on 25-May-2017
    Official Symbol
    Ica1provided by RGD
    Official Full Name
    islet cell autoantigen 1provided by RGD
    Primary source
    RGD:621465
    See related
    Ensembl:ENSRNOG00000008628
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ica69
    Summary
    arfaptin-related protein associated with membrane trafficking at the Golgi complex and immature secretory granules in neurosecretory cells; candidate gene for autoimmune target in type 1 diabetes [RGD, Feb 2006]
    Orthologs
    Location:
    4q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (34635509..34780187, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (34493594..34639924, complement)

    Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene glucocorticoid induced 1 Neighboring gene replication protein A3 Neighboring gene uncharacterized LOC102550643 Neighboring gene neurexophilin 1 Neighboring gene similar to TGF beta-inducible nuclear protein 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
      Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type I diabetes mellitus, conserved biosystem (from KEGG)
      Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein homodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Golgi stack IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule membrane IEA
    Inferred from Electronic Annotation
    more info
     
    secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    islet cell autoantigen 1
    Names
    69 kDa islet cell autoantigen
    ICAp69
    islet cell autoantigen 1, 69 kDa
    islet cell autoantigen p69
    p69

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030844.2NP_110471.2  islet cell autoantigen 1

      See identical proteins and their annotated locations for NP_110471.2

      Status: PROVISIONAL

      Source sequence(s)
      BC078812
      UniProtKB/TrEMBL
      Q6AZ05
      Related
      ENSRNOP00000011651.4, ENSRNOT00000011651.5
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260480
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

      Range
      34635509..34780187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236095.3XP_006236157.1  islet cell autoantigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006236157.1

      UniProtKB/TrEMBL
      Q6AZ05
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260480
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    2. XM_006236094.3XP_006236156.1  islet cell autoantigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006236156.1

      UniProtKB/TrEMBL
      Q6AZ05
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260480
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    3. XM_008762728.2XP_008760950.1  islet cell autoantigen 1 isoform X2

      See identical proteins and their annotated locations for XP_008760950.1

      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260459
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    4. XM_006236092.3XP_006236154.1  islet cell autoantigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006236154.1

      UniProtKB/TrEMBL
      Q6AZ05
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260480
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    5. XM_006236093.3XP_006236155.1  islet cell autoantigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006236155.1

      UniProtKB/TrEMBL
      Q6AZ05
      Related
      ENSRNOP00000075191.1, ENSRNOT00000077329.1
      Conserved Domains (2) summary
      cd07661
      Location:52255
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:260480
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    Alternate Rn_Celera

    Genomic

    1. AC_000072.1 Alternate Rn_Celera

      Range
      32158705..32303677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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