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    LILRA2 leukocyte immunoglobulin like receptor A2 [ Homo sapiens (human) ]

    Gene ID: 11027, updated on 31-Aug-2017
    Official Symbol
    LILRA2provided by HGNC
    Official Full Name
    leukocyte immunoglobulin like receptor A2provided by HGNC
    Primary source
    HGNC:HGNC:6603
    See related
    Ensembl:ENSG00000239998 MIM:604812; Vega:OTTHUMG00000065703
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ILT1; LIR7; CD85H; LIR-7
    Summary
    This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]
    Orthologs
    Location:
    19q13.42
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (54572997..54587560)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55084469..55099027)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains X1 Neighboring gene uncharacterized LOC107985347 Neighboring gene uncharacterized LOC105372461 Neighboring gene leukocyte immunoglobulin like receptor A1 Neighboring gene leukocyte immunoglobulin like receptor B1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    IgM binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    antigen binding TAS
    Traceable Author Statement
    more info
    PubMed 
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    leukocyte immunoglobulin-like receptor subfamily A member 2
    Names
    CD85 antigen-like family member H
    immunoglobulin-like transcript 1
    leucocyte Ig-like receptor A2
    leukocyte immunoglobulin-like receptor 7
    leukocyte immunoglobulin-like receptor subfamily A member 2 soluble
    leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034038.1 RefSeqGene

      Range
      5001..19564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130917.2NP_001124389.2  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform a precursor

      See identical proteins and their annotated locations for NP_001124389.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC245036, AK310088, CB046242, U82278
      Consensus CDS
      CCDS46179.1
      Related
      ENSP00000375618.3, ENST00000391738.7
      Conserved Domains (2) summary
      smart00410
      Location:35116
      IG_like; Immunoglobulin like
      cl11960
      Location:27117
      Ig; Immunoglobulin domain
    2. NM_001290270.1NP_001277199.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform c precursor

      See identical proteins and their annotated locations for NP_001277199.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks in-frame exons in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC245036, AK310088, CB046242, U82276
      Consensus CDS
      CCDS74453.1
      UniProtKB/TrEMBL
      A8MZH0
      Related
      ENSP00000375617.1, OTTHUMP00000068395, ENST00000391737.3, OTTHUMT00000140814
      Conserved Domains (2) summary
      smart00410
      Location:23104
      IG_like; Immunoglobulin like
      cl11960
      Location:15105
      Ig; Immunoglobulin domain
    3. NM_001290271.1NP_001277200.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform d precursor

      See identical proteins and their annotated locations for NP_001277200.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, and lacks an exon and contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is longer than isoform a.
      Source sequence(s)
      AC245036, AK310088, CB046242, DA264697
      Conserved Domains (2) summary
      smart00410
      Location:35116
      IG_like; Immunoglobulin like
      cl11960
      Location:122217
      Ig; Immunoglobulin domain
    4. NM_006866.3NP_006857.2  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC245036, BC027916, CB046242, DA465773, DA931441
      Consensus CDS
      CCDS12900.1
      UniProtKB/Swiss-Prot
      Q8N149
      Related
      ENSP00000251376.3, OTTHUMP00000068396, ENST00000251376.7, OTTHUMT00000140815
      Conserved Domains (2) summary
      smart00410
      Location:35116
      IG_like; Immunoglobulin like
      cl11960
      Location:27117
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      54572997..54587560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722986.1XP_006723049.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X1

      See identical proteins and their annotated locations for XP_006723049.1

      Conserved Domains (2) summary
      smart00410
      Location:35116
      IG_like; Immunoglobulin like
      cl11960
      Location:122217
      Ig; Immunoglobulin domain
    2. XM_011526385.1XP_011524687.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X2

      See identical proteins and their annotated locations for XP_011524687.1

      Conserved Domains (2) summary
      smart00410
      Location:35116
      IG_like; Immunoglobulin like
      cl11960
      Location:27117
      Ig; Immunoglobulin domain
    3. XM_017026224.1XP_016881713.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X6

    4. XM_011526386.1XP_011524688.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X3

      Conserved Domains (2) summary
      smart00410
      Location:23104
      IG_like; Immunoglobulin like
      cl11960
      Location:110205
      Ig; Immunoglobulin domain
    5. XM_011526387.1XP_011524689.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X4

      See identical proteins and their annotated locations for XP_011524689.1

      UniProtKB/TrEMBL
      A8MZH0
      Conserved Domains (2) summary
      smart00410
      Location:23104
      IG_like; Immunoglobulin like
      cl11960
      Location:15105
      Ig; Immunoglobulin domain
    6. XM_011526389.1XP_011524691.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X7

      Conserved Domains (2) summary
      smart00410
      Location:128189
      IG_like; Immunoglobulin like
      cl11960
      Location:16111
      Ig; Immunoglobulin domain
    7. XM_011526388.1XP_011524690.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X5

      Conserved Domains (2) summary
      smart00410
      Location:23104
      IG_like; Immunoglobulin like
      cl11960
      Location:15105
      Ig; Immunoglobulin domain
    8. XM_011526390.1XP_011524692.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X8

      Related
      ENSP00000388131.1, OTTHUMP00000068397, ENST00000439534.5, OTTHUMT00000140818
      Conserved Domains (2) summary
      smart00410
      Location:35116
      IG_like; Immunoglobulin like
      cl11960
      Location:122217
      Ig; Immunoglobulin domain
    9. XM_011526391.1XP_011524693.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X9

      Conserved Domains (2) summary
      smart00410
      Location:35116
      IG_like; Immunoglobulin like
      cl11960
      Location:122217
      Ig; Immunoglobulin domain

    Reference GRCh38.p7 ALT_REF_LOCI_1

    Genomic

    1. NW_003571054.1 Reference GRCh38.p7 ALT_REF_LOCI_1

      Range
      479387..493950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_7

    Genomic

    1. NW_003571060.1 Reference GRCh38.p7 ALT_REF_LOCI_7

      Range
      477882..492444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p7 ALT_REF_LOCI_9

      Range
      555578..570141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      55078016..55092579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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