Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Fgfr4 fibroblast growth factor receptor 4 [ Mus musculus (house mouse) ]

    Gene ID: 14186, updated on 6-Aug-2017
    Official Symbol
    Fgfr4provided by MGI
    Official Full Name
    fibroblast growth factor receptor 4provided by MGI
    Primary source
    MGI:MGI:95525
    See related
    Ensembl:ENSMUSG00000005320 Vega:OTTMUSG00000035043
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fgfr-4
    Orthologs
    Location:
    13 B1; 13 29.8 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (55152818..55168759)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55254179..55270120)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene zinc finger protein 346 Neighboring gene predicted gene, 46415 Neighboring gene nuclear receptor-binding SET-domain protein 1 Neighboring gene RAB24, member RAS oncogene family

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    alveolar secondary septum development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fibroblast growth factor production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    organ induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphate ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of parathyroid hormone secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of bile acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of phosphorus metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vacuolar phosphate transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vitamin D3 metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    fibroblast growth factor receptor 4
    Names
    CTLA-2-beta protein
    fibroblast growth factor receptor 4 16 minus form
    protein-tyrosine kinase receptor MPK-11
    NP_032037.2
    XP_006517162.2
    XP_006517163.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008011.2NP_032037.2  fibroblast growth factor receptor 4 precursor

      See identical proteins and their annotated locations for NP_032037.2

      Status: VALIDATED

      Source sequence(s)
      AK084850
      Consensus CDS
      CCDS26540.1
      UniProtKB/Swiss-Prot
      Q03142
      UniProtKB/TrEMBL
      A0A0R4IZY3
      Related
      ENSMUSP00000005452.5, OTTMUSP00000048664, ENSMUST00000005452.5, OTTMUST00000089130
      Conserved Domains (6) summary
      cd05099
      Location:451764
      PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4
      cd05858
      Location:261348
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:47104
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:159238
      IG_like; Immunoglobulin like
      pfam07714
      Location:464740
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:154238
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      55152818..55168759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517099.2XP_006517162.2  fibroblast growth factor receptor 4 isoform X1

    2. XM_006517100.1XP_006517163.1  fibroblast growth factor receptor 4 isoform X2

      Conserved Domains (4) summary
      cd05099
      Location:205518
      PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4
      cd05858
      Location:15102
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00410
      Location:7101
      IG_like; Immunoglobulin like
      pfam07714
      Location:218494
      Pkinase_Tyr; Protein tyrosine kinase
    Support Center