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    INPPL1 inositol polyphosphate phosphatase like 1 [ Homo sapiens (human) ]

    Gene ID: 3636, updated on 16-Jul-2017
    Official Symbol
    INPPL1provided by HGNC
    Official Full Name
    inositol polyphosphate phosphatase like 1provided by HGNC
    Primary source
    HGNC:HGNC:6080
    See related
    Ensembl:ENSG00000165458 MIM:600829; Vega:OTTHUMG00000167879
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OPSMD; SHIP2
    Summary
    The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]
    Orthologs
    Location:
    11q13.4
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (72223861..72239147)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71934916..71950191)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene folate receptor 1 Neighboring gene folate receptor beta Neighboring gene paired like homeobox 2a Neighboring gene dedicator of cytokinesis 1 pseudogene Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity TAS
    Traceable Author Statement
    more info
     
    phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    endochondral ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    inositol phosphate metabolic process TAS
    Traceable Author Statement
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
     
    phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
    Names
    51C protein
    INPPL-1
    SH2 domain-containing inositol-5'-phosphatase 2
    SHIP-2
    protein 51C
    NP_001558.3
    XP_005274035.1
    XP_005274036.1
    XP_011543301.1
    XP_011543302.1
    XP_016873162.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023253.1 RefSeqGene

      Range
      5001..19310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001567.3NP_001558.3  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

      See identical proteins and their annotated locations for NP_001558.3

      Status: REVIEWED

      Source sequence(s)
      BC140853, BG236320, Y14385
      Consensus CDS
      CCDS8213.1
      UniProtKB/Swiss-Prot
      O15357
      Related
      ENSP00000298229.2, OTTHUMP00000237158, ENST00000298229.6, OTTHUMT00000396789
      Conserved Domains (4) summary
      cd09491
      Location:11941256
      SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
      cd09101
      Location:424727
      INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
      smart00454
      Location:12021258
      SAM; Sterile alpha motif
      cd10343
      Location:17119
      SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      72223861..72239147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017673.1XP_016873162.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2

    2. XM_005273979.4XP_005274036.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

      See identical proteins and their annotated locations for XP_005274036.1

      Conserved Domains (4) summary
      cd09491
      Location:12161278
      SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
      cd09101
      Location:446749
      INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
      smart00454
      Location:12241280
      SAM; Sterile alpha motif
      cd10343
      Location:17119
      SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    3. XM_011545000.2XP_011543302.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X4

      Conserved Domains (2) summary
      cd09101
      Location:446749
      INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
      cd10343
      Location:17119
      SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    4. XM_011544999.2XP_011543301.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X3

      See identical proteins and their annotated locations for XP_011543301.1

      UniProtKB/Swiss-Prot
      O15357
      Conserved Domains (4) summary
      cd09491
      Location:11941256
      SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
      cd09101
      Location:424727
      INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
      smart00454
      Location:12021258
      SAM; Sterile alpha motif
      cd10343
      Location:17119
      SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    5. XM_005273978.3XP_005274035.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

      See identical proteins and their annotated locations for XP_005274035.1

      Conserved Domains (4) summary
      cd09491
      Location:12161278
      SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
      cd09101
      Location:446749
      INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
      smart00454
      Location:12241280
      SAM; Sterile alpha motif
      cd10343
      Location:17119
      SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      71819333..71833642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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