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    Usp14 ubiquitin specific peptidase 14 [ Mus musculus (house mouse) ]

    Gene ID: 59025, updated on 6-Feb-2017
    Official Symbol
    Usp14provided by MGI
    Official Full Name
    ubiquitin specific peptidase 14provided by MGI
    Primary source
    MGI:MGI:1928898
    See related
    Ensembl:ENSMUSG00000047879 Vega:OTTMUSG00000020274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ax; C78769; nmf375; AW107924; 2610005K12Rik; 2610037B11Rik
    Orthologs
    Location:
    18 A1; 18 4.91 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (9993615..10030149, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (9993613..10030147, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene cell division cycle associated 7 pseudogene Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene THO complex 1 Neighboring gene Rho-associated coiled-coil containing protein kinase 1 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene high mobility group box 3 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Targeted (2) 
    • Chemically induced (ENU) (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    proteasome binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiol-dependent ubiquitinyl hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ER-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 14
    Names
    ataxia
    dUB-type TGT for deubiquitinating enzyme
    deubiquitinating enzyme 14
    ubiquitin specific protease 14
    ubiquitin thioesterase 14
    ubiquitin thiolesterase 14
    ubiquitin-specific-processing protease 14
    NP_001033678.1
    NP_067497.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038589.2NP_001033678.1  ubiquitin carboxyl-terminal hydrolase 14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163451, CB520876, CJ161902, CK621440, CN531861
      Consensus CDS
      CCDS37734.1
      UniProtKB/TrEMBL
      E9PYI8
      Related
      ENSMUSP00000112368, OTTMUSP00000021968, ENSMUST00000116669, OTTMUST00000048113
      Conserved Domains (3) summary
      cd02657
      Location:71445
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      pfam00443
      Location:69444
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl00155
      Location:564
      UBQ; Ubiquitin-like proteins
    2. NM_021522.4NP_067497.2  ubiquitin carboxyl-terminal hydrolase 14 isoform 1

      See identical proteins and their annotated locations for NP_067497.2

      Status: VALIDATED

      Source sequence(s)
      AC163451, AK011322, AK029977, CJ161902
      Consensus CDS
      CCDS37735.1
      UniProtKB/Swiss-Prot
      Q9JMA1
      Related
      ENSMUSP00000089728, OTTMUSP00000021967, ENSMUST00000092096, OTTMUST00000048112
      Conserved Domains (4) summary
      smart00213
      Location:574
      UBQ; Ubiquitin homologues
      cd02657
      Location:106480
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      pfam00443
      Location:104479
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl00155
      Location:574
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      9993615..10030149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526134.3XP_006526197.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X1

      Conserved Domains (3) summary
      cd02657
      Location:80454
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      pfam00443
      Location:78453
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl00155
      Location:148
      UBQ; Ubiquitin-like proteins
    2. XM_017317959.1XP_017173448.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X2

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