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    CASP3 caspase 3 [ Homo sapiens (human) ]

    Gene ID: 836, updated on 6-Jun-2017
    Official Symbol
    CASP3provided by HGNC
    Official Full Name
    caspase 3provided by HGNC
    Primary source
    HGNC:HGNC:1504
    See related
    Ensembl:ENSG00000164305 MIM:600636; Vega:OTTHUMG00000133681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPP32; SCA-1; CPP32B
    Summary
    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    4q35.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 4 NC_000004.12 (184627696..184649475, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (185548850..185570629, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene GAR1 ribonucleoprotein homolog (yeast) pseudogene Neighboring gene long intergenic non-protein coding RNA 2365 Neighboring gene primase and DNA directed polymerase Neighboring gene centromere protein U Neighboring gene acyl-CoA synthetase long chain family member 1 Neighboring gene proteoglycan 3 pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Mutational analysis shows that HIV-1 gp120 R476K and N425R are associated with the bystander apoptosis-inducing activity of Env glycoprotein through caspase 3 PubMed
    env Treatment of astrocytes with HIV-1 gp120 induces the cleavage of CASP3 as compared with untreated cells PubMed
    env HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells PubMed
    env HIV-1 R5-tropic Env-mediated apoptosis of bystander cells is dependent on both CCR5 expression levels and fusogenic activity of the Env glycoprotein through the mechanism of apoptosis involved caspase-3 activation and mitochondrial depolarization PubMed
    env Treatment of HIV-1 Env-pseudotyped virus-infected MDM cells with both soluble TRAIL and an agonistic anti-DR5 antibody AD5-10 induces activation of caspase-3, -8, and -9 PubMed
    env HIV-1 gp120-mediated activation of caspase 8 occurs in a p53 independent manner, while HIV-1 gp120-mediated activation of caspase 3 requires p53 PubMed
    env Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 PubMed
    env Inactivation of PKR has an inhibitory effect on gp120-induced caspase-3 activation PubMed
    env Gp120-mediated activation of caspase-3 is significantly reduced in cells pretreated with PDGF-B PubMed
    env The combinatorial toxicity of cocaine and gp120 is accompanied by an increase in both caspase-3 activity and expression of the proapoptotic protein Bax in HIV-associated neuropathological disorders PubMed
    env The cytolytic process that takes place between primary uninfected CD4+ T cells and HIV-1 infected or HIV-1 gp120-expressing cells requires the activity of caspases such as ICE and CPP32 PubMed
    env The interaction of cell-associated HIV-1 gp120 with CXCR4-expressing target cells triggers apoptotic processes by activating caspase-9 and -3 PubMed
    env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
    env Signal transducer and activator of transcription factor 1 (STAT1) partially regulates HIV-1 gp120/HCV E2-induced caspase 3 activity PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells PubMed
    env HIV-1 gp41-dependent apoptosis involves caspase-3-dependent mitochondrial depolarization and reactive oxygen species production; HIV-1 gp41-induced mitochondrial depolarization is inhibited by the protease inhibitor nelfinavir PubMed
    env HIV-1 R5-tropic Env-mediated apoptosis of bystander cells is dependent on both CCR5 expression levels and fusogenic activity of the Env glycoprotein through the mechanism of apoptosis involved caspase-3 activation and mitochondrial depolarization PubMed
    env Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 PubMed
    env A point mutation (V38E) in the gp41 region of HIV-1 abolishes HIV-1-mediated apoptosis by CASP3 and minimizes CD4 loss in humanized mice without altering viral replication PubMed
    Nef nef Stable expression of HIV-1 Nef in CEM T cells activates caspase-3 and enhances apoptosis through mechanisms unrelated to Fas PubMed
    nef Stable expression of HIV-1 Nef in Jurkat T cells confers resistance to Fas-mediated apoptosis through inactivation of caspase-3 and caspase-8 PubMed
    nef Microarray and Western blot analyses have shown HIV-1 Nef-induced apoptosis in human brain micro vascular endothelial cells requires the involvement of caspase-3 and caspase-9 PubMed
    Pr55(Gag) gag Monocyte-derived macrophages selectively capture and engulf HIV-1-infected CD4+ T cells as HIV-1 Gag interacts with CD3 and Caspase 3 markers, leading to efficient macrophage infection PubMed
    Tat tat HIV-1 clade B and C Tat induce cleavage of both PARP and CASP3 in primary glia PubMed
    tat CB1 and CB2 endocannabinoid receptors are involved in HIV-1 Tat-induced cleavage of PARP1 and CASP3 in retinal cells PubMed
    tat FasL-induced activation of caspase-3 and -8 proteins is inhibited in HIV-1 Tat101-expressing Jurkat cells PubMed
    tat HIV-1 Tat induces apoptosis through activation of caspase-3 PubMed
    tat The levels of caspase-3 protein are reduced after Caco-2 cells exposure to HIV-1 Tat compared with control PubMed
    tat PDGF-BB prevents caspase-3 activation induced by HIV-1 Tat and morphine in neuroblastoma cells PubMed
    tat Tat-triggered PKCdelta and PKCtheta activation results in the downstream signaling through the apoptosis pathways mediated by both ERK1/2 and caspase-3 PubMed
    tat Co-administration of morphine and HIV-1 Tat significantly increases the percentage of neurons expressing active caspase-3 PubMed
    tat HIV-1 Tat-induced apoptosis through increased expression of anti-apoptotic protein Bcl-2, proapoptotic protein Bax and activation of caspases CASP3 and CASP9 is inhibited by estrogen receptor beta (ER)-mediated estrogen treatment PubMed
    tat A p53 fusion protein with the HIV-1 Tat basic domain at its N terminus activates the expression of p21and downregulates the levels of caspase-3 and Bcl-2 PubMed
    Vpr vpr Visualization of HIV-1 Vpr-induced cell cycle arrest in G2 phase and apoptosis in HeLa/Fucci2 cells is associated with caspase-3 activation PubMed
    vpr Through activation of the caspase 9 pathway, HIV-1 Vpr also activates caspase 3 PubMed
    vpr Induction of G2 cell cycle arrest by Vpr is upregulated under caspase 3-inhibition and induction of apoptosis by Vpr is downregulated by caspase 3-inhibition PubMed
    vpr Inhibition of caspase 3 by compound Z-DEVD-fmk causes accumulation of HIV-1 Vpr at the nuclear envelope. VprL23F and VprP35A mutants abrogate the sensitivity to caspase 3-inhibition PubMed
    vpr HIV-1 Vpr increases the activity of caspase-3 and caspase-9, but not of caspase-8 in human HeLa cells; Vpr-induced apoptosis can be inhibited by inhibitors of caspase-3 and caspase-9, but not by inhibitors of caspase-8 PubMed
    vpr HIV-1 Vpr-induced apoptosis results in caspase 3 cleavage PubMed
    vpr HIV-1 Vpr segments with mutation at the positions 70, 85, 86, or 94 show lower apoptosis-inducing capabilities by the attenuation of Caspase-3 activity PubMed
    vpr Virion-associated Vpr activates caspase 3/7, 8, and 9 in Fas-mediated apoptosis in Jurkat T cells and human activated PBMCs PubMed
    vpr Virion-associated Vpr triggers apoptosis through caspases 3/7 and 9 in human T cells independently of other HIV de novo-expressed proteins and also activates caspase 8, the initiator caspase of the death receptor pathway PubMed
    vpr HIV-1 Vpr-induced apoptosis through caspase activation and Smac release from mitochondria is dependent on G2 cell cycle arrest , but is lost in cells synchronized in G1/S PubMed
    vpr Overproduction of EEF2 blocks HIV-1 Vpr-induced cell death both in fission yeast and human cells, suppresses caspase 9 and caspase 3-mediated apoptosis induced by Vpr, and reduces cytochrome c release induced by Vpr PubMed
    Vpu vpu Caspase-8 and caspase-3 activity are required for HIV-1 Vpu-induced cleavage of IRF3 and HIV-1 infection also induces caspase-mediated IRF3 cleavage PubMed
    vpu Levels of active caspase-3 are elevated in T cells as a result of HIV-1 Vpu-mediated inhibition of NF-kappa B activation PubMed
    retropepsin gag-pol HIV-1 PR cleaves CASP3 to result in three processed products, Myr-lyn signal peptide, p17 and p12 proteins PubMed
    gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed

    Go to the HIV-1, Human Interaction Database

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    • Alzheimer's disease, conserved biosystem (from KEGG)
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    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from WikiPathways)
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    • Colorectal cancer, organism-specific biosystem (from KEGG)
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    • HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
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    • Integrated Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Cancer Pathway, organism-specific biosystem
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      NADE modulates death signalling, organism-specific biosystemNADE protein (p75NTR-associated cell death executor) may induce cell death upon NGF binding, but not BDNF, NT3, or NT4/5 binding, to p75NTR. The NADE-dependent apoptosis is modulated by the 14-3-3-ep...
    • Nanomaterial induced apoptosis, organism-specific biosystem (from WikiPathways)
      Nanomaterial induced apoptosis, organism-specific biosystemApotosis caused by nanomaterials, such as single-walled carbon nanohorns, titanium oxide, and polystyrene nanoparticles, may be induced through lysosomal impairment. For example, PAMAMs have been fou...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Oncostatin M Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Oncostatin M Signaling Pathway, organism-specific biosystemOncostatin M (OSM) is a member of the multifunctional cytokine interleukin 6 (IL6) - type cytokine family. It is mainly produced in cell types such as activated T lymphocytes, macrophages, monocytes,...
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
    • Parkinsons Disease Pathway, organism-specific biosystem (from WikiPathways)
      Parkinsons Disease Pathway, organism-specific biosystemMost people with Parkinson's disease have idiopathic Parkinson's disease (having no specific known cause). A small proportion of cases, however, can be attributed to known genetic factors. Mutations ...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Platinum drug resistance, organism-specific biosystem (from KEGG)
      Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
    • Platinum drug resistance, conserved biosystem (from KEGG)
      Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
    • Programmed Cell Death, organism-specific biosystem (from REACTOME)
      Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
    • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem
      Role of Calcineurin-dependent NFAT signaling in lymphocytes
    • SMAC binds to IAPs, organism-specific biosystem (from REACTOME)
      SMAC binds to IAPs, organism-specific biosystemSMAC binds to the XIAP:caspase complexes.
    • SMAC-mediated apoptotic response, organism-specific biosystem (from REACTOME)
      SMAC-mediated apoptotic response, organism-specific biosystemOnce released from the mitochondria, SMAC binds to IAP family proteins displacing them from Caspase:IAP complexes liberating the active caspases.
    • SMAC-mediated dissociation of IAP:caspase complexes, organism-specific biosystem (from REACTOME)
      SMAC-mediated dissociation of IAP:caspase complexes, organism-specific biosystemSmac/DIABLO regulates IAP function. Residues 56-59 of Smac/DIABLO are homologous to the amino-terminal motif that is used by caspase-9 to bind to the BIR3 domain of XIAP. Binding of Smac/DIABLO to ...
    • Serotonergic synapse, organism-specific biosystem (from KEGG)
      Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Hippo, organism-specific biosystem (from REACTOME)
      Signaling by Hippo, organism-specific biosystemHuman Hippo signaling is a network of reactions that regulates cell proliferation and apoptosis, centered on a three-step kinase cascade. The cascade was discovered by analysis of Drosophila mutation...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    • Stimulation of the cell death response by PAK-2p34, organism-specific biosystem (from REACTOME)
      Stimulation of the cell death response by PAK-2p34, organism-specific biosystemIn response to stress signals, the p21-activated protein kinase PAK-2 stimulates a cell death response characterized by increased cell rounding and apoptotic chromatin condensation (see Jakobi et al...
    • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-2-mediated signaling events, organism-specific biosystem
      Syndecan-2-mediated signaling events
    • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...
    • TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, organism-specific biosystemTNF related weak inducer of apoptosis (TWEAK) is a small pleiotropic cytokine of the TNF super family and its gene is located at chromosome 17p13.1. TWEAK has been reported to be expressed in tissues...
    • TNF signaling pathway, organism-specific biosystem (from KEGG)
      TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • TNF signaling pathway, conserved biosystem (from KEGG)
      TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
    • miRNA Regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
      miRNA Regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...
    • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
      p75(NTR)-mediated signaling, organism-specific biosystem
      p75(NTR)-mediated signaling
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
    Traceable Author Statement
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c TAS
    Traceable Author Statement
    more info
     
    apoptotic DNA fragmentation TAS
    Traceable Author Statement
    more info
     
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to staurosporine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    erythrocyte differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    execution phase of apoptosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    execution phase of apoptosis TAS
    Traceable Author Statement
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand TAS
    Traceable Author Statement
    more info
     
    glial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    hippo signaling TAS
    Traceable Author Statement
    more info
     
    hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway in response to osmotic stress IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    learning or memory IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of activated T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neurotrophin TRK receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet formation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of macroautophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    response to UV IEA
    Inferred from Electronic Annotation
    more info
     
    response to X-ray IEA
    Inferred from Electronic Annotation
    more info
     
    response to amino acid IEA
    Inferred from Electronic Annotation
    more info
     
    response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
     
    response to cobalt ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    response to tumor necrosis factor TAS
    Traceable Author Statement
    more info
    PubMed 
    sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    death-inducing signaling complex IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    caspase-3
    Names
    CASP-3
    CPP-32
    PARP cleavage protease
    SREBP cleavage activity 1
    apopain
    caspase 3, apoptosis-related cysteine peptidase
    caspase 3, apoptosis-related cysteine protease
    cysteine protease CPP32
    procaspase3
    protein Yama
    NP_004337.2
    NP_116786.1
    XP_011530603.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004346.3NP_004337.2  caspase-3 preproprotein

      See identical proteins and their annotated locations for NP_004337.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) represents the longer transcript.
      Source sequence(s)
      AU127028, BC016926, BU753483
      Consensus CDS
      CCDS3836.1
      UniProtKB/Swiss-Prot
      P42574
      Related
      ENSP00000311032.4, OTTHUMP00000165052, ENST00000308394.8, OTTHUMT00000257885
      Conserved Domains (1) summary
      smart00115
      Location:37277
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    2. NM_032991.2NP_116786.1  caspase-3 preproprotein

      See identical proteins and their annotated locations for NP_116786.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta) differs in the 5' UTR, compared to variant alpha.
      Source sequence(s)
      AU127028, BC016926, BU753483
      Consensus CDS
      CCDS3836.1
      UniProtKB/Swiss-Prot
      P42574
      Related
      ENSP00000428929.1, OTTHUMP00000165054, ENST00000523916.5, OTTHUMT00000257887
      Conserved Domains (1) summary
      smart00115
      Location:37277
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p7 Primary Assembly

      Range
      184627696..184649475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532301.1XP_011530603.1  caspase-3 isoform X1

      See identical proteins and their annotated locations for XP_011530603.1

      UniProtKB/Swiss-Prot
      P42574
      Conserved Domains (1) summary
      smart00115
      Location:37277
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      185525377..185547156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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