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    Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 13075, updated on 15-Oct-2017
    Official Symbol
    Cyp19a1provided by MGI
    Official Full Name
    cytochrome P450, family 19, subfamily a, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:88587
    See related
    Ensembl:ENSMUSG00000032274 Vega:OTTMUSG00000063201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ar; ArKO; Int5; Cyp19; Int-5; p450arom
    Orthologs
    Location:
    9 A5.3; 9 29.49 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (54165859..54229532, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (54013744..54041249, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene ELMO/CED-12 domain containing 1 Neighboring gene tumor necrosis factor, alpha-induced protein 8-like 3 Neighboring gene gliomedin, opposite strand Neighboring gene gliomedin Neighboring gene Dmx-like 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC124251, MGC124252

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    C21-steroid hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    androgen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    androgen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    androgen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    calcineurin-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    female genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of chronic inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of macrophage chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of estradiol secretion ISO
    Inferred from Sequence Orthology
    more info
     
    prostate gland growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synapse structure or activity ISO
    Inferred from Sequence Orthology
    more info
     
    testosterone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    uterus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    aromatase
    Names
    CYPXIX
    cytochrome P-450AROM
    cytochrome P450 19A1
    cytochrome P450, 19, aromatase
    estrogen synthase
    NP_031836.1
    XP_006510868.1
    XP_006510869.1
    XP_006510871.1
    XP_006510872.1
    XP_011240963.1
    XP_017168612.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348171.1NP_001335100.1  aromatase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. Expression of this variant has been found in adipose tissue.
      Source sequence(s)
      AC159816, AC162180
      UniProtKB/Swiss-Prot
      P28649
      UniProtKB/TrEMBL
      Q3ZAT3
      Conserved Domains (1) summary
      pfam00067
      Location:48488
      p450; Cytochrome P450
    2. NM_001348172.1NP_001335101.1  aromatase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. Expression of this variant has been found in brain.
      Source sequence(s)
      AC159816, AC162180
      UniProtKB/Swiss-Prot
      P28649
      UniProtKB/TrEMBL
      Q3ZAT3
      Conserved Domains (1) summary
      pfam00067
      Location:48488
      p450; Cytochrome P450
    3. NM_001348173.1NP_001335102.1  aromatase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. Expression of this variant has been found in testis.
      Source sequence(s)
      AC159816, AC162180
      UniProtKB/Swiss-Prot
      P28649
      UniProtKB/TrEMBL
      Q3ZAT3
      Conserved Domains (1) summary
      pfam00067
      Location:48488
      p450; Cytochrome P450
    4. NM_007810.4NP_031836.1  aromatase

      See identical proteins and their annotated locations for NP_031836.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein. Expression of this variant has been found in gonads.
      Source sequence(s)
      AC159816, AC162180
      Consensus CDS
      CCDS23187.1
      UniProtKB/Swiss-Prot
      P28649
      UniProtKB/TrEMBL
      Q3ZAT3
      Related
      ENSMUSP00000034811.7, ENSMUST00000034811.7
      Conserved Domains (1) summary
      pfam00067
      Location:48488
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      54165859..54229532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242661.2XP_011240963.1  aromatase isoform X3

      See identical proteins and their annotated locations for XP_011240963.1

      Conserved Domains (1) summary
      pfam00067
      Location:1329
      p450; Cytochrome P450
    2. XM_006510808.3XP_006510871.1  aromatase isoform X2

      See identical proteins and their annotated locations for XP_006510871.1

      Conserved Domains (1) summary
      pfam00067
      Location:1386
      p450; Cytochrome P450
    3. XM_006510809.3XP_006510872.1  aromatase isoform X2

      See identical proteins and their annotated locations for XP_006510872.1

      Conserved Domains (1) summary
      pfam00067
      Location:1386
      p450; Cytochrome P450
    4. XM_017313123.1XP_017168612.1  aromatase isoform X2

      Conserved Domains (1) summary
      pfam00067
      Location:1386
      p450; Cytochrome P450
    5. XM_006510805.3XP_006510868.1  aromatase isoform X1

      Conserved Domains (1) summary
      pfam00067
      Location:48488
      p450; Cytochrome P450
    6. XM_006510806.3XP_006510869.1  aromatase isoform X1

      Conserved Domains (1) summary
      pfam00067
      Location:48488
      p450; Cytochrome P450
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