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    TOB1 transducer of ERBB2, 1 [ Homo sapiens (human) ]

    Gene ID: 10140, updated on 8-Oct-2017
    Official Symbol
    TOB1provided by HGNC
    Official Full Name
    transducer of ERBB2, 1provided by HGNC
    Primary source
    HGNC:HGNC:11979
    See related
    Ensembl:ENSG00000141232 MIM:605523; Vega:OTTHUMG00000162277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TOB; TROB; APRO5; APRO6; PIG49; TROB1
    Summary
    This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
    Orthologs
    Location:
    17q21.33
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (50862223..50867978, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48939584..48945339, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 Neighboring gene ribosomal protein L5 pseudogene 33 Neighboring gene TOB1 antisense RNA 1 Neighboring gene uncharacterized LOC105371825 Neighboring gene sperm associated antigen 9

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Bone Morphogenic Protein (BMP) Signalling and Regulation, organism-specific biosystem (from WikiPathways)
      Bone Morphogenic Protein (BMP) Signalling and Regulation, organism-specific biosystem"BMP signals are mediated by type I and II BMP receptors and their downstream molecules Smad1, 5 and 8. Phosphorylated Smad1, 5 and 8 proteins form a complex with Smad4 and then are translocated into...
    • Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystem (from WikiPathways)
      Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
    • RNA degradation, organism-specific biosystem (from KEGG)
      RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • RNA degradation, conserved biosystem (from KEGG)
      RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC34446, MGC104792

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3/SH2 adaptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor tyrosine kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    protein Tob1
    Names
    proliferation-inducing gene 49
    transducer of erbB-2 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243877.1NP_001230806.1  protein Tob1 isoform 1

      See identical proteins and their annotated locations for NP_001230806.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK313904, BC031406
      Consensus CDS
      CCDS11576.1
      UniProtKB/Swiss-Prot
      P50616
      Related
      ENSP00000268957.3, OTTHUMP00000221804, ENST00000268957.3, OTTHUMT00000368364
      Conserved Domains (1) summary
      smart00099
      Location:1106
      btg1; tob/btg1 family
    2. NM_001243885.1NP_001230814.1  protein Tob1 isoform 2

      See identical proteins and their annotated locations for NP_001230814.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA675891, AK313904, BC031406, DA039934
      UniProtKB/Swiss-Prot
      P50616
    3. NM_005749.3NP_005740.1  protein Tob1 isoform 1

      See identical proteins and their annotated locations for NP_005740.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      BC031406, BC098415, DA039934
      Consensus CDS
      CCDS11576.1
      UniProtKB/Swiss-Prot
      P50616
      Related
      ENSP00000427695.1, OTTHUMP00000221803, ENST00000499247.2, OTTHUMT00000368363
      Conserved Domains (1) summary
      smart00099
      Location:1106
      btg1; tob/btg1 family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      50862223..50867978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      49003687..49009428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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