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    Irak3 interleukin-1 receptor-associated kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 73914, updated on 6-Aug-2017
    Official Symbol
    Irak3provided by MGI
    Official Full Name
    interleukin-1 receptor-associated kinase 3provided by MGI
    Primary source
    MGI:MGI:1921164
    See related
    Ensembl:ENSMUSG00000020227 Vega:OTTMUSG00000034096
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IRAK-M; AI563835; 4833428C18Rik
    Orthologs
    Location:
    10; 10 D2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (120141648..120201744, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (119578710..119638593, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene glutamate receptor interacting protein 1 Neighboring gene glutamate receptor interacting protein 1, opposite strand 1 Neighboring gene helicase (DNA) B Neighboring gene predicted gene, 34545 Neighboring gene predicted gene, 40781 Neighboring gene predicted gene, 38500 Neighboring gene predicted gene, 40782 Neighboring gene transmembrane BAX inhibitor motif containing 4

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MyD88-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-1-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cytokine-mediated signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macrophage cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macrophage tolerance induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    regulation of protein complex disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to peptidoglycan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to virus IC
    Inferred by Curator
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    interleukin-1 receptor-associated kinase 3
    Names
    IL-1 receptor-associated kinase M
    IRAK-3
    irak3
    NP_082955.2
    XP_006514290.1
    XP_006514291.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028679.3NP_082955.2  interleukin-1 receptor-associated kinase 3

      See identical proteins and their annotated locations for NP_082955.2

      Status: PROVISIONAL

      Source sequence(s)
      AK029057
      Consensus CDS
      CCDS24204.1
      UniProtKB/Swiss-Prot
      Q8K4B2
      UniProtKB/TrEMBL
      Q0VB14
      Related
      ENSMUSP00000020448.4, OTTMUSP00000046651, ENSMUST00000020448.10, OTTMUST00000086213
      Conserved Domains (3) summary
      cd08796
      Location:16102
      Death_IRAK-M; Death domain of Interleukin 1 Receptor Associated Kinase-M
      cd14160
      Location:184459
      PK_IRAK3; Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3
      pfam07714
      Location:184456
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      120141648..120201744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514228.3XP_006514291.1  interleukin-1 receptor-associated kinase 3 isoform X1

      See identical proteins and their annotated locations for XP_006514291.1

      Conserved Domains (1) summary
      cl21453
      Location:1247
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006514227.3XP_006514290.1  interleukin-1 receptor-associated kinase 3 isoform X1

      See identical proteins and their annotated locations for XP_006514290.1

      Conserved Domains (1) summary
      cl21453
      Location:1247
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_380448.2 RNA Sequence

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