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    Pcsk1 proprotein convertase subtilisin/kexin type 1 [ Mus musculus (house mouse) ]

    Gene ID: 18548, updated on 10-Sep-2017
    Official Symbol
    Pcsk1provided by MGI
    Official Full Name
    proprotein convertase subtilisin/kexin type 1provided by MGI
    Primary source
    MGI:MGI:97511
    See related
    Ensembl:ENSMUSG00000021587 Vega:OTTMUSG00000026053
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PC1; PC3; Nec1; SPC3; Nec-1; Phpp-1
    Orthologs
    Location:
    13 C1; 13 40.63 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (75089420..75134861)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (75227435..75269946)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like 2, pseudogene Neighboring gene predicted gene, 30867 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 4 pseudogene Neighboring gene taxilin alpha pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Clone Names

    • MGC124320, MGC124321

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    peptide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide hormone processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    neuroendocrine convertase 1
    Names
    NEC 1
    furin homolog
    prohormone convertase 1
    prohormone convertase 1/3
    propeptide-processing protease
    proprotein convertase 1
    NP_038656.1
    XP_006517216.1
    XP_006517217.1
    XP_006517218.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013628.2NP_038656.1  neuroendocrine convertase 1 precursor

      See identical proteins and their annotated locations for NP_038656.1

      Status: PROVISIONAL

      Source sequence(s)
      AC158543
      Consensus CDS
      CCDS26649.1
      UniProtKB/Swiss-Prot
      P63239
      UniProtKB/TrEMBL
      Q32MU0
      Related
      ENSMUSP00000022075.4, OTTMUSP00000031918, ENSMUST00000022075.5, OTTMUST00000064311
      Conserved Domains (5) summary
      cd04059
      Location:121415
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:158432
      Peptidase_S8; Subtilase family
      pfam01483
      Location:504591
      P_proprotein; Proprotein convertase P-domain
      pfam12177
      Location:715751
      Proho_convert; Prohormone convertase enzyme
      pfam16470
      Location:34110
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      75089420..75134861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517154.3XP_006517217.1  neuroendocrine convertase 1 isoform X1

      See identical proteins and their annotated locations for XP_006517217.1

      UniProtKB/Swiss-Prot
      P63239
      UniProtKB/TrEMBL
      Q32MU0
      Conserved Domains (5) summary
      cd04059
      Location:121415
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:158432
      Peptidase_S8; Subtilase family
      pfam01483
      Location:504591
      P_proprotein; Proprotein convertase P-domain
      pfam12177
      Location:715751
      Proho_convert; Prohormone convertase enzyme
      pfam16470
      Location:34110
      S8_pro-domain; Peptidase S8 pro-domain
    2. XM_006517153.2XP_006517216.1  neuroendocrine convertase 1 isoform X1

      See identical proteins and their annotated locations for XP_006517216.1

      UniProtKB/Swiss-Prot
      P63239
      UniProtKB/TrEMBL
      Q32MU0
      Conserved Domains (5) summary
      cd04059
      Location:121415
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:158432
      Peptidase_S8; Subtilase family
      pfam01483
      Location:504591
      P_proprotein; Proprotein convertase P-domain
      pfam12177
      Location:715751
      Proho_convert; Prohormone convertase enzyme
      pfam16470
      Location:34110
      S8_pro-domain; Peptidase S8 pro-domain
    3. XM_006517155.2XP_006517218.1  neuroendocrine convertase 1 isoform X1

      See identical proteins and their annotated locations for XP_006517218.1

      UniProtKB/Swiss-Prot
      P63239
      UniProtKB/TrEMBL
      Q32MU0
      Conserved Domains (5) summary
      cd04059
      Location:121415
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:158432
      Peptidase_S8; Subtilase family
      pfam01483
      Location:504591
      P_proprotein; Proprotein convertase P-domain
      pfam12177
      Location:715751
      Proho_convert; Prohormone convertase enzyme
      pfam16470
      Location:34110
      S8_pro-domain; Peptidase S8 pro-domain
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