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    Pgf placental growth factor [ Mus musculus (house mouse) ]

    Gene ID: 18654, updated on 25-May-2017
    Official Symbol
    Pgfprovided by MGI
    Official Full Name
    placental growth factorprovided by MGI
    Primary source
    MGI:MGI:105095
    See related
    Ensembl:ENSMUSG00000004791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PIGF; Plgf; AI854365
    Orthologs
    Location:
    12 D1; 12 39.58 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (85166637..85177785, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (86507591..86518235, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) Neighboring gene ribosomal protein S6 kinase-like 1 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene eukaryotic translation initiation factor 2B, subunit 2 beta

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
      Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystem (from REACTOME)
      VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • VEGF ligand-receptor interactions, organism-specific biosystem (from REACTOME)
      VEGF ligand-receptor interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    vascular endothelial growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    branching involved in ureteric bud morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    induction of positive chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mast cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of morphogenesis of a branching structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    vascular endothelial growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271705.1NP_001258634.1  placenta growth factor isoform 2

      See identical proteins and their annotated locations for NP_001258634.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC127582, AK042891
      UniProtKB/TrEMBL
      Q544A5
      Conserved Domains (1) summary
      smart00141
      Location:179
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    2. NM_008827.3NP_032853.1  placenta growth factor isoform 1 precursor

      See identical proteins and their annotated locations for NP_032853.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). An in-frame AUG is located 4 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
      Source sequence(s)
      AC127582, AK042891
      Consensus CDS
      CCDS49115.1
      UniProtKB/Swiss-Prot
      P49764
      UniProtKB/TrEMBL
      Q544A5
      Related
      ENSMUSP00000004913.6, ENSMUST00000004913.6
      Conserved Domains (1) summary
      smart00141
      Location:46129
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      85166637..85177785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244016.1XP_011242318.1  placenta growth factor isoform X1

      Conserved Domains (1) summary
      smart00141
      Location:50131
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    2. XM_006515585.1XP_006515648.1  placenta growth factor isoform X2

      See identical proteins and their annotated locations for XP_006515648.1

      Conserved Domains (1) summary
      smart00141
      Location:179
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
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