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    WNT5A Wnt family member 5A [ Homo sapiens (human) ]

    Gene ID: 7474, updated on 25-Jun-2017
    Official Symbol
    WNT5Aprovided by HGNC
    Official Full Name
    Wnt family member 5Aprovided by HGNC
    Primary source
    HGNC:HGNC:12784
    See related
    Ensembl:ENSG00000114251 MIM:164975; Vega:OTTHUMG00000158361
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hWNT5A
    Summary
    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
    Orthologs
    Location:
    3p14.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (55465715..55505261, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (55499743..55521670, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377097 Neighboring gene long intergenic non-protein coding RNA 2030 Neighboring gene uncharacterized LOC105377100 Neighboring gene ELKS/RAB6-interacting/CAST family member 2 Neighboring gene ERC2 intronic transcript 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of WNT5a in human neural stem cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Asymmetric localization of PCP proteins, organism-specific biosystem (from REACTOME)
      Asymmetric localization of PCP proteins, organism-specific biosystemOne of the hallmarks of the Planar Cell Polarity pathway is the asymmetric distribution of proteins on opposite membranes of a single cell. In Drosophila, Stbm and Pk (homologues to the human VANGL1/...
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Basal cell carcinoma, organism-specific biosystem (from KEGG)
      Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Basal cell carcinoma, conserved biosystem (from KEGG)
      Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Beta-catenin independent WNT signaling, organism-specific biosystem (from REACTOME)
      Beta-catenin independent WNT signaling, organism-specific biosystemHumans and mice have 19 identified WNT proteins that were originally classified as either 'canonical' or 'non-canonical' depending upon whether they were able to transform the mouse mammary epithelia...
    • Breast cancer, organism-specific biosystem (from KEGG)
      Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Breast cancer, conserved biosystem (from KEGG)
      Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Ca2+ pathway, organism-specific biosystem (from REACTOME)
      Ca2+ pathway, organism-specific biosystemA number of so called non-canonical WNT ligands have been shown to promote intracellular calcium release upon FZD binding. This beta-catenin-independent WNT pathway acts through heterotrimeric G pro...
    • Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystemRecruitment of plasma membrane-localized cargo into clathrin-coated endocytic vesicles is mediated by interaction with a variety of clathrin-interacting proteins collectively called CLASPs (clathrin-...
    • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
      Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
    • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
    • DNA Damage Response (only ATM dependent), organism-specific biosystem (from WikiPathways)
      DNA Damage Response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
    • Differentiation Pathway, organism-specific biosystem (from WikiPathways)
      Differentiation Pathway, organism-specific biosystemThis pathway provides an overview of the directed differentiation molecules used to induce early and derivative cell lineages from human pluripotent stem cells. The initial version of this pathway is...
    • Extracellular vesicle-mediated signaling in recipient cells, organism-specific biosystem (from WikiPathways)
      Extracellular vesicle-mediated signaling in recipient cells, organism-specific biosystemProtein sorting during formation of multivesicular bodies results in packaging of key molecules in exosomes. Exosomes bound-signaling ligands once released from host cells interacts with the receptor...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Melanogenesis, organism-specific biosystem (from KEGG)
      Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Melanogenesis, conserved biosystem (from KEGG)
      Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
    • Negative regulation of TCF-dependent signaling by WNT ligand antagonists, organism-specific biosystem (from REACTOME)
      Negative regulation of TCF-dependent signaling by WNT ligand antagonists, organism-specific biosystemSeveral unrelated families of secreted proteins antagonize WNT signaling. Secreted frizzled-related proteins (sFRPs) have a cysteine rich domain (CRD) that is also found in FZD and ROR receptors, wh...
    • Noncanonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Noncanonical Wnt signaling pathway, organism-specific biosystem
      Noncanonical Wnt signaling pathway
    • PCP/CE pathway, organism-specific biosystem (from REACTOME)
      PCP/CE pathway, organism-specific biosystemThe planar cell polarity (PCP) pathway controls the establishment of polarity within the plane of a sheet of cells. PCP was initially characterized in Drosophila, where it controls the arrangement o...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
    • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
      TCF dependent signaling in response to WNT, organism-specific biosystem19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of ...
    • Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional repression, organism-specific biosystem
      Validated targets of C-MYC transcriptional repression
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    • WNT ligand biogenesis and trafficking, organism-specific biosystem (from REACTOME)
      WNT ligand biogenesis and trafficking, organism-specific biosystem19 WNT proteins have been identified in human cells. The WNTs are members of a conserved metazoan family of secreted morphogens that activate several signaling pathways in the responding cell: the c...
    • WNT5A-dependent internalization of FZD2, FZD5 and ROR2, organism-specific biosystem (from REACTOME)
      WNT5A-dependent internalization of FZD2, FZD5 and ROR2, organism-specific biosystemInternalization of FZD2, FZD5 and ROR2 after WNT5A binding is thought to occur in a clathrin-dependent manner and is required for the activation of RAC signaling (Kurayoshi et al, 2007; Sato et al, 2...
    • WNT5A-dependent internalization of FZD4, organism-specific biosystem (from REACTOME)
      WNT5A-dependent internalization of FZD4, organism-specific biosystemWNT5A induces internalization of FZD4 in a manner that depends upon PKC-mediated phosphorylation of DVL2. Uptake of FZD4 appears to occur in a clathrin, AP-2 and ARBB2-dependent mannner (Chen et al,...
    • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
    • Wnt signaling, organism-specific biosystem (from KEGG)
      Wnt signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • Wnt signaling, conserved biosystem (from KEGG)
      Wnt signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • Wnt signaling network, organism-specific biosystem (from Pathway Interaction Database)
      Wnt signaling network, organism-specific biosystem
      Wnt signaling network
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chemoattractant activity involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    frizzled binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    frizzled-2 binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    receptor agonist activity IC
    Inferred by Curator
    more info
    PubMed 
    receptor tyrosine kinase-like orphan receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt signaling pathway TAS
    Traceable Author Statement
    more info
     
    Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Wnt signaling pathway, calcium modulating pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt signaling pathway, calcium modulating pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Wnt signaling pathway, calcium modulating pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Wnt signaling pathway, planar cell polarity pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of MAPK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of protein kinase B activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anterior/posterior axis specification, embryo IEA
    Inferred from Electronic Annotation
    more info
     
    axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to interferon-gamma IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to retinoic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cervix development IEA
    Inferred from Electronic Annotation
    more info
     
    chemoattraction of serotonergic neuron axon IEA
    Inferred from Electronic Annotation
    more info
     
    chemorepulsion of dopaminergic neuron axon IEA
    Inferred from Electronic Annotation
    more info
     
    cochlea morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    convergent extension involved in axis elongation IEA
    Inferred from Electronic Annotation
    more info
     
    convergent extension involved in organogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell proliferation involved in mammary gland duct elongation IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial to mesenchymal transition IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    establishment of epithelial cell apical/basal polarity IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of planar polarity IEA
    Inferred from Electronic Annotation
    more info
     
    excitatory synapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    face development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hindgut morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    hypophysis morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    inhibitory synapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    keratinocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    lateral sprouting involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    lens development in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mammary gland branching involved in thelarche IEA
    Inferred from Electronic Annotation
    more info
     
    melanocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    membrane organization TAS
    Traceable Author Statement
    more info
     
    mesenchymal-epithelial cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    mesodermal to mesenchymal transition involved in gastrulation IEA
    Inferred from Electronic Annotation
    more info
     
    midgut development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of axon extension involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell proliferation in midbrain NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of melanin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mesenchymal cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of prostatic bud formation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    non-canonical Wnt signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    non-canonical Wnt signaling pathway via JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    notochord morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    olfactory bulb interneuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    optic cup formation involved in camera-type eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    palate development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    paraxial mesoderm formation IEA
    Inferred from Electronic Annotation
    more info
     
    planar cell polarity pathway involved in axis elongation IEA
    Inferred from Electronic Annotation
    more info
     
    planar cell polarity pathway involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    planar cell polarity pathway involved in cardiac muscle tissue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    planar cell polarity pathway involved in cardiac right atrium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    planar cell polarity pathway involved in gastrula mediolateral intercalation IEA
    Inferred from Electronic Annotation
    more info
     
    planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    planar cell polarity pathway involved in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    planar cell polarity pathway involved in outflow tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    planar cell polarity pathway involved in pericardium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    planar cell polarity pathway involved in ventricular septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cGMP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell-cell adhesion mediated by cadherin IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytokine secretion involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-1 beta secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-8 secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of macrophage cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mesenchymal cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of non-canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein kinase C activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase C signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein localization to synapse TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of thymocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of timing of anagen IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of type I interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    post-anal tail morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    postsynapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    presynapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    primitive streak formation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of branching involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cellular protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    response to organic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    type B pancreatic cell development IEA
    Inferred from Electronic Annotation
    more info
     
    urinary bladder development IEA
    Inferred from Electronic Annotation
    more info
     
    uterus development IEA
    Inferred from Electronic Annotation
    more info
     
    vagina development IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi lumen TAS
    Traceable Author Statement
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-coated endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    clathrin-coated vesicle membrane TAS
    Traceable Author Statement
    more info
     
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    extracellular exosome TAS
    Traceable Author Statement
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    protein Wnt-5a
    Names
    WNT-5A protein
    wingless-type MMTV integration site family, member 5A

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031992.1 RefSeqGene

      Range
      5001..26928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256105.1NP_001243034.1  protein Wnt-5a isoform 2 precursor

      See identical proteins and their annotated locations for NP_001243034.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC121764, AK290869, BU742635, DB224740
      Consensus CDS
      CCDS58835.1
      UniProtKB/Swiss-Prot
      P41221
      UniProtKB/TrEMBL
      A0A024R316
      Related
      ENSP00000420104.1, OTTHUMP00000212861, ENST00000497027.5, OTTHUMT00000350845
      Conserved Domains (1) summary
      pfam00110
      Location:60365
      wnt; wnt family
    2. NM_003392.4NP_003383.2  protein Wnt-5a isoform 1

      See identical proteins and their annotated locations for NP_003383.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC121764, AK090582, BC064694, BU742635
      Consensus CDS
      CCDS46850.1
      UniProtKB/Swiss-Prot
      P41221
      UniProtKB/TrEMBL
      B3KQX9
      Related
      ENSP00000264634.4, ENST00000264634.8
      Conserved Domains (1) summary
      pfam00110
      Location:75380
      wnt; wnt family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      55465715..55505261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007127.1XP_016862616.1  protein Wnt-5a isoform X1

    2. XM_011534086.2XP_011532388.1  protein Wnt-5a isoform X2

      See identical proteins and their annotated locations for XP_011532388.1

      UniProtKB/Swiss-Prot
      P41221
      UniProtKB/TrEMBL
      A0A024R316
      Conserved Domains (1) summary
      pfam00110
      Location:60365
      wnt; wnt family
    3. XM_017007128.1XP_016862617.1  protein Wnt-5a isoform X2

      UniProtKB/Swiss-Prot
      P41221
      UniProtKB/TrEMBL
      A0A024R316
      Conserved Domains (1) summary
      pfam00110
      Location:60365
      wnt; wnt family
    4. XM_011534085.2XP_011532387.1  protein Wnt-5a isoform X2

      See identical proteins and their annotated locations for XP_011532387.1

      UniProtKB/Swiss-Prot
      P41221
      UniProtKB/TrEMBL
      A0A024R316
      Conserved Domains (1) summary
      pfam00110
      Location:60365
      wnt; wnt family
    5. XM_006713324.1XP_006713387.1  protein Wnt-5a isoform X2

      See identical proteins and their annotated locations for XP_006713387.1

      UniProtKB/Swiss-Prot
      P41221
      UniProtKB/TrEMBL
      A0A024R316
      Conserved Domains (1) summary
      pfam00110
      Location:60365
      wnt; wnt family
    6. XM_011534087.2XP_011532389.1  protein Wnt-5a isoform X2

      See identical proteins and their annotated locations for XP_011532389.1

      UniProtKB/Swiss-Prot
      P41221
      UniProtKB/TrEMBL
      A0A024R316
      Conserved Domains (1) summary
      pfam00110
      Location:60365
      wnt; wnt family
    7. XM_011534088.2XP_011532390.1  protein Wnt-5a isoform X2

      See identical proteins and their annotated locations for XP_011532390.1

      UniProtKB/Swiss-Prot
      P41221
      UniProtKB/TrEMBL
      A0A024R316
      Conserved Domains (1) summary
      pfam00110
      Location:60365
      wnt; wnt family
    8. XM_011534089.1XP_011532391.1  protein Wnt-5a isoform X2

      See identical proteins and their annotated locations for XP_011532391.1

      UniProtKB/Swiss-Prot
      P41221
      UniProtKB/TrEMBL
      A0A024R316
      Conserved Domains (1) summary
      pfam00110
      Location:60365
      wnt; wnt family

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      55451089..55473010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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