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    CHKA choline kinase alpha [ Homo sapiens (human) ]

    Gene ID: 1119, updated on 12-Mar-2017
    Official Symbol
    CHKAprovided by HGNC
    Official Full Name
    choline kinase alphaprovided by HGNC
    Primary source
    HGNC:HGNC:1937
    See related
    Ensembl:ENSG00000110721 MIM:118491; Vega:OTTHUMG00000167424
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CK; EK; CHK; CKI
    Summary
    The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    11q13.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (68052859..68121391, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67820326..67888858, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit S8 Neighboring gene microRNA 4691 Neighboring gene T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 Neighboring gene microRNA 6753 Neighboring gene uncharacterized LOC105369362 Neighboring gene lysine methyltransferase 5B

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    choline binding IEA
    Inferred from Electronic Annotation
    more info
     
    choline kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    choline kinase activity TAS
    Traceable Author Statement
    more info
     
    cholinesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    drug binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ethanolamine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ethanolamine kinase activity TAS
    Traceable Author Statement
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    CDP-choline pathway IEA
    Inferred from Electronic Annotation
    more info
     
    choline metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    ethanolamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    lipid transport TAS
    Traceable Author Statement
    more info
    PubMed 
    phosphatidylcholine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylcholine biosynthetic process TAS
    Traceable Author Statement
    more info
     
    phosphatidylethanolamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylethanolamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylethanolamine biosynthetic process TAS
    Traceable Author Statement
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    response to 3-methylcholanthrene IEA
    Inferred from Electronic Annotation
    more info
     
    response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    choline kinase alpha
    Names
    CHETK-alpha
    ethanolamine kinase
    NP_001268.2
    NP_997634.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277.2NP_001268.2  choline kinase alpha isoform a

      See identical proteins and their annotated locations for NP_001268.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC036471, BG703955, BG723115, BI195927, BU617910, D10704
      Consensus CDS
      CCDS8178.1
      UniProtKB/Swiss-Prot
      P35790
      Related
      ENSP00000265689, OTTHUMP00000235913, ENST00000265689, OTTHUMT00000394570
      Conserved Domains (2) summary
      PLN02236
      Location:99455
      PLN02236; choline kinase
      cd05156
      Location:111452
      ChoK_euk; Euykaryotic Choline Kinase
    2. NM_212469.1NP_997634.1  choline kinase alpha isoform b

      See identical proteins and their annotated locations for NP_997634.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AI809679, AK054792, BC036471, BE260889, BG703955, BG723115, BU617910, D10704
      Consensus CDS
      CCDS8179.1
      UniProtKB/Swiss-Prot
      P35790
      Related
      ENSP00000348454, OTTHUMP00000235915, ENST00000356135, OTTHUMT00000394572
      Conserved Domains (2) summary
      PLN02236
      Location:99437
      PLN02236; choline kinase
      cd05156
      Location:111434
      ChoK_euk; Euykaryotic Choline Kinase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      68052859..68121391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017148.1XP_016872637.1  choline kinase alpha isoform X2

    2. XM_017017147.1XP_016872636.1  choline kinase alpha isoform X1

    RNA

    1. XR_949773.2 RNA Sequence

    2. XR_949772.2 RNA Sequence

    3. XR_949775.2 RNA Sequence

    4. XR_428905.2 RNA Sequence

    5. XR_428904.3 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      67704080..67773223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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