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    Nr2c1 nuclear receptor subfamily 2, group C, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 22025, updated on 22-Apr-2017
    Official Symbol
    Nr2c1provided by MGI
    Official Full Name
    nuclear receptor subfamily 2, group C, member 1provided by MGI
    Primary source
    MGI:MGI:1352465
    See related
    Ensembl:ENSMUSG00000005897 Vega:OTTMUSG00000022679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TR2; 80.3; Eenr; Tr2-11; 4831444H07Rik
    Orthologs
    Location:
    10 C2; 10 48.81 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (94147512..94197216)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (93610676..93659959)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene microRNA 331 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene B-cell CLL/lymphoma 9-like pseudogene Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 Neighboring gene predicted gene, 32749

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    nuclear receptor subfamily 2 group C member 1
    Names
    80-3 cNDA
    early embryonic nuclear receptor
    mTR2
    nr2c1
    nuclear receptor subfamily 2, group H, member 1
    orphan nuclear receptor TR2
    orphan receptor, TR2-11
    testicular receptor 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011629.3NP_035759.3  nuclear receptor subfamily 2 group C member 1

      See identical proteins and their annotated locations for NP_035759.3

      Status: VALIDATED

      Source sequence(s)
      AC138026, AK146891, AK149374
      Consensus CDS
      CCDS24131.1
      UniProtKB/Swiss-Prot
      Q505F1
      Related
      ENSMUSP00000100927.2, OTTMUSP00000025946, ENSMUST00000105290.8, OTTMUST00000054363
      Conserved Domains (2) summary
      cd06952
      Location:355576
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:96182
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      94147512..94197216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513592.2XP_006513655.1  nuclear receptor subfamily 2 group C member 1 isoform X1

      See identical proteins and their annotated locations for XP_006513655.1

      UniProtKB/Swiss-Prot
      Q505F1
      Related
      ENSMUSP00000089858.4, OTTMUSP00000025978, ENSMUST00000092213.10, OTTMUST00000054433
      Conserved Domains (2) summary
      cd06952
      Location:355576
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:96182
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    RNA

    1. XR_001779514.1 RNA Sequence

    2. XR_001779515.1 RNA Sequence

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