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    Tcl1 T cell lymphoma breakpoint 1 [ Mus musculus (house mouse) ]

    Gene ID: 21432, updated on 8-Oct-2017
    Official Symbol
    Tcl1provided by MGI
    Official Full Name
    T cell lymphoma breakpoint 1provided by MGI
    Primary source
    MGI:MGI:1097166
    See related
    Ensembl:ENSMUSG00000041359 Vega:OTTMUSG00000042098
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcl1a
    Location:
    12 E; 12 55.28 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (105216753..105222737, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (106454963..106460947, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene T cell leukemia/lymphoma 1B, 3 Neighboring gene T cell leukemia/lymphoma 1B, 4 Neighboring gene Tcl1 upstream neural differentiation associated RNA Neighboring gene predicted gene 2721

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
      Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    T-cell leukemia/lymphoma protein 1A
    Names
    TCL-1
    oncogene TCL-1
    oncogene TCL1
    protein p14 TCL1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289468.1NP_001276397.1  T-cell leukemia/lymphoma protein 1A isoform 2

      See identical proteins and their annotated locations for NP_001276397.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a longer and distinct C-terminus.
      Source sequence(s)
      AK149361, DV653827, DV660020
      Consensus CDS
      CCDS70418.1
      UniProtKB/TrEMBL
      Q3UES7
      Related
      ENSMUSP00000098632.3, OTTMUSP00000061588, ENSMUST00000101071.3, OTTMUST00000110420
      Conserved Domains (1) summary
      pfam01840
      Location:198
      TCL1_MTCP1; TCL1/MTCP1 family
    2. NM_001309484.1NP_001296413.1  T-cell leukemia/lymphoma protein 1A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal exon and contains an alternate internal exon, resulting in the use of an alternate start codon, compared to variant 2. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      CJ087217, DV646075, DV649899, DV653827, DV660020
    3. NM_001309485.1NP_001296414.1  T-cell leukemia/lymphoma protein 1A isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in its 3' coding region and contains an alternate internal exon, resulting in a frameshift and an early stop codon, compared to variant 2. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      CA558861, DV646075, DV653827, DV655843, DV660020
      Consensus CDS
      CCDS83999.1
      UniProtKB/TrEMBL
      H3BJP6
      Related
      ENSMUSP00000135069.1, OTTMUSP00000061609, ENSMUST00000176579.1, OTTMUST00000110451
      Conserved Domains (1) summary
      pfam01840
      Location:180
      TCL1_MTCP1; TCL1/MTCP1 family
    4. NM_009337.3NP_033363.1  T-cell leukemia/lymphoma protein 1A isoform 1

      See identical proteins and their annotated locations for NP_033363.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK163387, BC052336, DV653827
      Consensus CDS
      CCDS36549.1
      UniProtKB/Swiss-Prot
      P56280
      Related
      ENSMUSP00000036066.8, OTTMUSP00000061587, ENSMUST00000041316.14, OTTMUST00000110419
      Conserved Domains (1) summary
      pfam01840
      Location:1110
      TCL1_MTCP1; TCL1/MTCP1 family

    RNA

    1. NR_110339.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CJ087554, DV648028, DV653827, DV660020, DV663230

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      105216753..105222737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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