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    IGFBP3 insulin like growth factor binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 3486, updated on 22-Sep-2016
    Official Symbol
    IGFBP3provided by HGNC
    Official Full Name
    insulin like growth factor binding protein 3provided by HGNC
    Primary source
    HGNC:HGNC:5472
    See related
    Ensembl:ENSG00000146674 HPRD:00899; MIM:146732; Vega:OTTHUMG00000023769
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IBP3; BP-53
    Summary
    This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    7p12.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (45912245..45921272, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (45951844..45960871, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene septin 14 pseudogene 7 Neighboring gene insulin like growth factor binding protein 1 Neighboring gene uncharacterized LOC102723446 Neighboring gene RNA, U7 small nuclear 76 pseudogene Neighboring gene uncharacterized LOC105375264 Neighboring gene ferritin light chain pseudogene 15

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.
    NHGRI GWA Catalog
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    NHGRI GWA Catalog
    Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.
    NHGRI GWA Catalog
    Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    fibronectin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    insulin-like growth factor I binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    insulin-like growth factor II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    insulin-like growth factor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    metal ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine phosphatase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of smooth muscle cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of insulin-like growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    type B pancreatic cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin-like growth factor binding protein complex IC
    Inferred by Curator
    more info
    PubMed 
    insulin-like growth factor ternary complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    insulin-like growth factor-binding protein 3
    Names
    IBP-3
    IGF-binding protein 3
    IGFBP-3
    acid stable subunit of the 140 K IGF complex
    binding protein 29
    binding protein 53
    growth hormone-dependent binding protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011508.1 RefSeqGene

      Range
      5001..14028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000598.4NP_000589.2  insulin-like growth factor-binding protein 3 isoform b precursor

      See identical proteins and their annotated locations for NP_000589.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform b).
      Source sequence(s)
      AI142967, AK056274, AU102436, BC064987
      Consensus CDS
      CCDS5505.1
      UniProtKB/Swiss-Prot
      P17936
      UniProtKB/TrEMBL
      B3KPF0
      Related
      ENSP00000275521, OTTHUMP00000159562, ENST00000275521, OTTHUMT00000251356
      Conserved Domains (2) summary
      smart00121
      Location:38115
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:213285
      Thyroglobulin_1; Thyroglobulin type-1 repeat
    2. NM_001013398.1NP_001013416.1  insulin-like growth factor-binding protein 3 isoform a precursor

      See identical proteins and their annotated locations for NP_001013416.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC091524, AI142967, AL540642, BC064987, X64875
      Consensus CDS
      CCDS34632.1
      UniProtKB/Swiss-Prot
      P17936
      Related
      ENSP00000370473, OTTHUMP00000214350, ENST00000381083, OTTHUMT00000353842
      Conserved Domains (2) summary
      smart00121
      Location:38115
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:219291
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      45912245..45921272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012152.1XP_016867641.1  

      Related
      ENSP00000480717, ENST00000615754
      Conserved Domains (2) summary
      smart00121
      Location:38115
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:213285
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      45956047..45965072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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