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    IKZF1 IKAROS family zinc finger 1 [ Homo sapiens (human) ]

    Gene ID: 10320, updated on 23-May-2018
    Official Symbol
    IKZF1provided by HGNC
    Official Full Name
    IKAROS family zinc finger 1provided by HGNC
    Primary source
    HGNC:HGNC:13176
    See related
    Ensembl:ENSG00000185811 MIM:603023; Vega:OTTHUMG00000155907
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452
    Summary
    This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
    Expression
    Biased expression in lymph node (RPKM 13.3), appendix (RPKM 8.6) and 10 other tissues See more
    Orthologs
    See IKZF1 in Genome Data Viewer
    Location:
    7p12.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (50303453..50405101)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (50344378..50367358) , (50444231..50472799)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zona pellucida binding protein Neighboring gene G protein nucleolar 2 pseudogene 1 Neighboring gene spermatogenesis associated 48 Neighboring gene conserved acetylation island sequence 3 enhancer Neighboring gene RNA, U6 small nuclear 1091, pseudogene Neighboring gene fidgetin like 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Immunodeficiency, common variable, 13
    MedGen: C4225173 OMIM: 616873 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Confirmation of Childhood Acute Lymphoblastic Leukemia Variants, ARID5B and IKZF1, and Interaction with Parental Environmental Exposures.
    NHGRI GWA Catalog
    Discovery and refinement of loci associated with lipid levels.
    NHGRI GWA Catalog
    Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
    NHGRI GWA Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    NHGRI GWA Catalog
    Germline genomic variants associated with childhood acute lymphoblastic leukemia.
    NHGRI GWA Catalog
    Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
    NHGRI GWA Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    NHGRI GWA Catalog
    Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.
    NHGRI GWA Catalog
    Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
    NHGRI GWA Catalog
    Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
    NHGRI GWA Catalog
    Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.
    NHGRI GWA Catalog
    Seventy-five genetic loci influencing the human red blood cell.
    NHGRI GWA Catalog
    Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Ikaros is identified to interact with HIV-1 Tat in Jurkat cell by GST pull-down and by WB PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA
    Inferred from Sequence Alignment
    more info
     
    RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesoderm development TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein heterooligomerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Preferred Names
    DNA-binding protein Ikaros
    Names
    CLL-associated antigen KW-6
    ikaros family zinc finger protein 1
    lymphoid transcription factor LyF-1
    protein phosphatase 1, regulatory subunit 92
    zinc finger protein, subfamily 1A, 1 (Ikaros)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034231.1 RefSeqGene

      Range
      5634..106019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001220765.2NP_001207694.1  DNA-binding protein Ikaros isoform 2

      See identical proteins and their annotated locations for NP_001207694.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2, also known as Ikx) is shorter than isoform 1, and it contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:11489963). Both variants 2 and 14 encode isoform 2.
      Source sequence(s)
      AY377974, BC018349, BM148203, DB148957, JX459579
      Consensus CDS
      CCDS59055.1
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Related
      ENSP00000352123.5, OTTHUMP00000208888, ENST00000359197.9, OTTHUMT00000342243
      Conserved Domains (2) summary
      sd00017
      Location:119139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132156
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001220767.2NP_001207696.1  DNA-binding protein Ikaros isoform 4

      See identical proteins and their annotated locations for NP_001207696.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (4, also known as Ik-2(del) as described in PMID:9892693) is shorter than isoform 1. This isoform contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:9892693).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Conserved Domains (2) summary
      COG5048
      Location:1131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6080
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. NM_001220768.2NP_001207697.1  DNA-binding protein Ikaros isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (5, also known as Ik-3 as described in PMID:12937159) is shorter than isoform 1. This isoform contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:9892693).
      Source sequence(s)
      JX459579, U40462
      Consensus CDS
      CCDS75597.1
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Related
      ENSP00000349928.4, ENST00000357364.8
      Conserved Domains (2) summary
      sd00017
      Location:119139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132156
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001220770.2NP_001207699.1  DNA-binding protein Ikaros isoform 7

      See identical proteins and their annotated locations for NP_001207699.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an alternate in-frame exon in both the 5' and central coding regions, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (7, also known as Ik-4(del) as described in PMID:9892693), is shorter than isoform 1. This isoform contains only two N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Conserved Domains (3) summary
      COG5048
      Location:1112
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6080
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:7297
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001220771.2NP_001207700.1  DNA-binding protein Ikaros isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks three consecutive alternate in-frame exons in the central coding region, compared to variant 1. The encoded isoform (8, also known as Ik-5 as described in PMID:12937159) is shorter than isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant-negative isoform.
      Source sequence(s)
      BC018349, JX459579
      Consensus CDS
      CCDS69299.1
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Related
      ENSP00000342485.4, ENST00000349824.8
    6. NM_001291837.1NP_001278766.1  DNA-binding protein Ikaros isoform 2

      See identical proteins and their annotated locations for NP_001278766.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2, also known as Ikx) is shorter than isoform 1, and it contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:11489963). Both variants 2 and 14 encode isoform 2.
      Source sequence(s)
      BC018349, DB122945, JX459579
      Consensus CDS
      CCDS59055.1
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Related
      ENSP00000413025.1, OTTHUMP00000208890, ENST00000439701.2, OTTHUMT00000342245
      Conserved Domains (2) summary
      sd00017
      Location:119139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132156
      zf-H2C2_2; Zinc-finger double domain
    7. NM_001291838.1NP_001278767.1  DNA-binding protein Ikaros isoform 3

      See identical proteins and their annotated locations for NP_001278767.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Ik-2) differs in the 5' UTR, and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (3, also known as Ik-2) is shorter than isoform 1, and is localized to the nucleus and contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:9892693).
      Source sequence(s)
      AK303586, DB122945, JX459579
      Consensus CDS
      CCDS78233.1
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Related
      ENSP00000396554.1, OTTHUMP00000208889, ENST00000438033.5, OTTHUMT00000342244
      Conserved Domains (2) summary
      COG5048
      Location:1131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6080
      ZF_C2H2; C2H2 Zn finger [structural motif]
    8. NM_001291839.1NP_001278768.1  DNA-binding protein Ikaros isoform 6

      See identical proteins and their annotated locations for NP_001278768.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Ik-4) differs in the 5' UTR, and lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1. The encoded isoform (6, also known as Ik-4 as described in PMID:12937159), is shorter than isoform 1. This isoform contains only two N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
      Source sequence(s)
      BC018349, DC391353, JX459579
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Conserved Domains (4) summary
      COG5048
      Location:1112
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6080
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:5880
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:7297
      zf-H2C2_2; Zinc-finger double domain
    9. NM_001291840.1NP_001278769.1  DNA-binding protein Ikaros isoform Ik-6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Ik-6) lacks four consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (Ik-6) is shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs, is localized to the cytoplasm and functions as a non-DNA-binding, dominant-negative isoform (PMIDs:12937159, 10463586).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
    10. NM_001291841.1NP_001278770.1  DNA-binding protein Ikaros isoform Ik-7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Ik-7) lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (Ik-7) is shorter than isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Related
      ENSP00000478368.1, ENST00000615491.4
      Conserved Domains (1) summary
      sd00017
      Location:6081
      ZF_C2H2; C2H2 Zn finger [structural motif]
    11. NM_001291842.1NP_001278771.1  DNA-binding protein Ikaros isoform Ik-7(del)

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Ik-7(del)) lacks two consecutive in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (Ik-7(del)) is shorter than isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Conserved Domains (1) summary
      sd00017
      Location:6081
      ZF_C2H2; C2H2 Zn finger [structural motif]
    12. NM_001291843.1NP_001278772.1  DNA-binding protein Ikaros isoform Ik-8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Ik-8) lacks three consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (Ik-8) is shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Related
      ENSP00000401507.3, ENST00000440768.6
    13. NM_001291844.1NP_001278773.1  DNA-binding protein Ikaros isoform Ik-8(del)

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Ik-8(del)) lacks three consecutive in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (Ik-8(del)) is shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
    14. NM_001291845.1NP_001278774.1  DNA-binding protein Ikaros isoform 15

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) lacks five 3' exons but contains an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (15) has a distinct C-terminus and is significantly shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs and is likely non-DNA-binding.
      Source sequence(s)
      BC064594, DB148957
      Consensus CDS
      CCDS78232.1
      UniProtKB/TrEMBL
      C9JTB0
      Related
      ENSP00000388478.1, OTTHUMP00000208892, ENST00000413698.5, OTTHUMT00000342248
    15. NM_001291846.1NP_001278775.1  DNA-binding protein Ikaros isoform 16

      See identical proteins and their annotated locations for NP_001278775.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) lacks five 3' exons but contains two alternate 3' exons, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (16) has a distinct C-terminus and is significantly shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs and is likely non-DNA-binding. Both variants 16 and 17 encode isoform 16.
      Source sequence(s)
      AW337855, BM148203, BU537824, DB148957
      Related
      ENSP00000493696.1, ENST00000646110.1
    16. NM_001291847.1NP_001278776.1  DNA-binding protein Ikaros isoform 16

      See identical proteins and their annotated locations for NP_001278776.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) differs in the 5' UTR, and lacks five 3' exons but contains two alternate 3' exons, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (16) has a distinct C-terminus and is significantly shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs and is likely non-DNA-binding. Both variants 16 and 17 encode isoform 16.
      Source sequence(s)
      AW337855, BU537824, DB122945
      Related
      ENSP00000494180.1, ENST00000492782.6
    17. NM_006060.6NP_006051.1  DNA-binding protein Ikaros isoform 1

      See identical proteins and their annotated locations for NP_006051.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1, also known as Ik-1 as described in PMID:12937159). This isoform contains four N-terminal zinc finger motifs, binds DNA, and is localized to the nucleus.
      Source sequence(s)
      BM148203, JX459579, U40462
      Consensus CDS
      CCDS75596.1
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Related
      ENSP00000496453.1, OTTHUMP00000208887, ENST00000644005.1
      Conserved Domains (2) summary
      sd00017
      Location:119139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132156
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      50303453..50405101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515078.2XP_011513380.1  DNA-binding protein Ikaros isoform X15

      See identical proteins and their annotated locations for XP_011513380.1

      Conserved Domains (2) summary
      COG5048
      Location:25136
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:84104
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_011515059.3XP_011513361.1  DNA-binding protein Ikaros isoform X2

      See identical proteins and their annotated locations for XP_011513361.1

      Conserved Domains (3) summary
      COG5048
      Location:188262
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:163183
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:176200
      zf-H2C2_2; Zinc-finger double domain
    3. XM_011515067.3XP_011513369.1  DNA-binding protein Ikaros isoform X6

      See identical proteins and their annotated locations for XP_011513369.1

      Conserved Domains (2) summary
      sd00017
      Location:163183
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:176200
      zf-H2C2_2; Zinc-finger double domain
    4. XM_011515074.2XP_011513376.1  DNA-binding protein Ikaros isoform X12

      See identical proteins and their annotated locations for XP_011513376.1

      Conserved Domains (2) summary
      COG5048
      Location:25155
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:84104
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. XM_011515070.2XP_011513372.1  DNA-binding protein Ikaros isoform X8

      See identical proteins and their annotated locations for XP_011513372.1

      Conserved Domains (2) summary
      sd00017
      Location:143163
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156180
      zf-H2C2_2; Zinc-finger double domain
    6. XM_011515077.2XP_011513379.1  DNA-binding protein Ikaros isoform X14

      See identical proteins and their annotated locations for XP_011513379.1

      Conserved Domains (2) summary
      COG5048
      Location:25136
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:84104
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. XM_011515058.2XP_011513360.1  DNA-binding protein Ikaros isoform X1

      See identical proteins and their annotated locations for XP_011513360.1

      Conserved Domains (3) summary
      COG5048
      Location:187343
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:163183
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:176200
      zf-H2C2_2; Zinc-finger double domain
    8. XM_011515071.2XP_011513373.1  DNA-binding protein Ikaros isoform X9

      See identical proteins and their annotated locations for XP_011513373.1

      Conserved Domains (4) summary
      COG5048
      Location:101175
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:104124
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:102124
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:116141
      zf-H2C2_2; Zinc-finger double domain
    9. XM_011515061.3XP_011513363.1  DNA-binding protein Ikaros isoform X4

      See identical proteins and their annotated locations for XP_011513363.1

      Conserved Domains (3) summary
      COG5048
      Location:168242
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:143163
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156180
      zf-H2C2_2; Zinc-finger double domain
    10. XM_011515072.2XP_011513374.1  DNA-binding protein Ikaros isoform X10

      See identical proteins and their annotated locations for XP_011513374.1

      Conserved Domains (2) summary
      COG5048
      Location:25155
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:84104
      ZF_C2H2; C2H2 Zn finger [structural motif]
    11. XM_011515076.2XP_011513378.1  DNA-binding protein Ikaros isoform X13

      See identical proteins and their annotated locations for XP_011513378.1

      UniProtKB/Swiss-Prot
      Q13422
      Conserved Domains (2) summary
      COG5048
      Location:1131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6080
      ZF_C2H2; C2H2 Zn finger [structural motif]
    12. XM_011515065.2XP_011513367.1  DNA-binding protein Ikaros isoform X5

      See identical proteins and their annotated locations for XP_011513367.1

      Conserved Domains (2) summary
      sd00017
      Location:139159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152176
      zf-H2C2_2; Zinc-finger double domain
    13. XM_017011669.1XP_016867158.1  DNA-binding protein Ikaros isoform X16

    14. XM_017011668.1XP_016867157.1  DNA-binding protein Ikaros isoform X13

      UniProtKB/Swiss-Prot
      Q13422
      Conserved Domains (2) summary
      COG5048
      Location:1131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6080
      ZF_C2H2; C2H2 Zn finger [structural motif]
    15. XM_011515063.2XP_011513365.1  DNA-binding protein Ikaros isoform X5

      See identical proteins and their annotated locations for XP_011513365.1

      Conserved Domains (2) summary
      sd00017
      Location:139159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152176
      zf-H2C2_2; Zinc-finger double domain
    16. XM_017011667.1XP_016867156.1  DNA-binding protein Ikaros isoform X11

      Conserved Domains (3) summary
      sd00017
      Location:80100
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:78100
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:92117
      zf-H2C2_2; Zinc-finger double domain
    17. XM_011515068.2XP_011513370.1  DNA-binding protein Ikaros isoform X7

      See identical proteins and their annotated locations for XP_011513370.1

      UniProtKB/Swiss-Prot
      Q13422
      Conserved Domains (2) summary
      sd00017
      Location:119139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132156
      zf-H2C2_2; Zinc-finger double domain
    18. XM_017011670.1XP_016867159.1  DNA-binding protein Ikaros isoform X16

    19. XM_011515066.2XP_011513368.1  DNA-binding protein Ikaros isoform X5

      See identical proteins and their annotated locations for XP_011513368.1

      Conserved Domains (2) summary
      sd00017
      Location:139159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152176
      zf-H2C2_2; Zinc-finger double domain
    20. XM_011515062.2XP_011513364.1  DNA-binding protein Ikaros isoform X5

      See identical proteins and their annotated locations for XP_011513364.1

      Conserved Domains (2) summary
      sd00017
      Location:139159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152176
      zf-H2C2_2; Zinc-finger double domain
    21. XM_011515073.2XP_011513375.1  DNA-binding protein Ikaros isoform X11

      Conserved Domains (3) summary
      sd00017
      Location:80100
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:78100
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:92117
      zf-H2C2_2; Zinc-finger double domain
    22. XM_011515075.2XP_011513377.1  DNA-binding protein Ikaros isoform X13

      See identical proteins and their annotated locations for XP_011513377.1

      UniProtKB/Swiss-Prot
      Q13422
      Related
      ENSP00000342750.5, ENST00000343574.9
      Conserved Domains (2) summary
      COG5048
      Location:1131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6080
      ZF_C2H2; C2H2 Zn finger [structural motif]
    23. XM_011515064.3XP_011513366.1  DNA-binding protein Ikaros isoform X5

      See identical proteins and their annotated locations for XP_011513366.1

      Conserved Domains (2) summary
      sd00017
      Location:139159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152176
      zf-H2C2_2; Zinc-finger double domain
    24. XM_011515069.2XP_011513371.1  DNA-binding protein Ikaros isoform X7

      See identical proteins and their annotated locations for XP_011513371.1

      UniProtKB/Swiss-Prot
      Q13422
      Conserved Domains (2) summary
      sd00017
      Location:119139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132156
      zf-H2C2_2; Zinc-finger double domain
    25. XM_011515060.2XP_011513362.1  DNA-binding protein Ikaros isoform X3

      See identical proteins and their annotated locations for XP_011513362.1

      Conserved Domains (3) summary
      COG5048
      Location:174248
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:149169
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:162186
      zf-H2C2_2; Zinc-finger double domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001220766.1: Suppressed sequence

      Description
      NM_001220766.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    2. NM_001220769.1: Suppressed sequence

      Description
      NM_001220769.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    3. NM_001220772.1: Suppressed sequence

      Description
      NM_001220772.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    4. NM_001220773.1: Suppressed sequence

      Description
      NM_001220773.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    5. NM_001220774.1: Suppressed sequence

      Description
      NM_001220774.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    6. NM_001220775.1: Suppressed sequence

      Description
      NM_001220775.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    7. NM_001220776.1: Suppressed sequence

      Description
      NM_001220776.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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