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    Chrna9 cholinergic receptor nicotinic alpha 9 subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65024, updated on 22-Apr-2017
    Official Symbol
    Chrna9provided by RGD
    Official Full Name
    cholinergic receptor nicotinic alpha 9 subunitprovided by RGD
    Primary source
    RGD:621534
    See related
    Ensembl:ENSRNOG00000002484
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    forms an acetylcholine activated homomeric receptor-channel complex; may modulate encoding of auditory stimuli in cochlear hair cells [RGD, Feb 2006]
    Orthologs
    Location:
    14p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (43883450..43890171, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (43670525..43677246, complement)

    Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene similar to ribosomal protein S23 Neighboring gene RNA binding motif protein 47 Neighboring gene uncharacterized LOC103692861 Neighboring gene similar to RIKEN cDNA 2410004L22 Neighboring gene NEDD4 binding protein 2 Neighboring gene ras homolog family member H

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    acetylcholine-gated cation-selective channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetylcholine-gated cation-selective channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acetylcholine-gated cation-selective channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    detection of mechanical stimulus involved in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    detection of mechanical stimulus involved in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    inner ear morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    inner ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of sound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetylcholine-gated channel complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acetylcholine-gated channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    neuronal acetylcholine receptor subunit alpha-9
    Names
    NACHR alpha-9
    acetylcholine receptor alpha 9 subunit (nAChR)
    cholinergic receptor, nicotinic, alpha 9 (neuronal)
    cholinergic receptor, nicotinic, alpha polypeptide 9
    nicotinic acetylcholine receptor subunit alpha-9

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022930.1NP_075219.1  neuronal acetylcholine receptor subunit alpha-9 precursor

      See identical proteins and their annotated locations for NP_075219.1

      Status: PROVISIONAL

      Source sequence(s)
      U12336
      UniProtKB/Swiss-Prot
      P43144
      Related
      ENSRNOP00000003382.2, ENSRNOT00000003382.3
      Conserved Domains (3) summary
      TIGR00860
      Location:8474
      LIC; Cation transporter family protein
      pfam02931
      Location:31236
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:244474
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

      Range
      43883450..43890171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000082.1 Alternate Rn_Celera

      Range
      41388099..41394795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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