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    Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) [ Mus musculus (house mouse) ]

    Gene ID: 17319, updated on 9-Apr-2017
    Official Symbol
    Mifprovided by MGI
    Official Full Name
    macrophage migration inhibitory factor (glycosylation-inhibiting factor)provided by MGI
    Primary source
    MGI:MGI:96982
    See related
    Ensembl:ENSMUSG00000033307
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GIF; Glif
    Orthologs
    Location:
    10 38.59 cM; 10 C1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (75859353..75860250, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (75322098..75322995, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, theta 4 Neighboring gene glutathione S-transferase, theta 2 Neighboring gene predicted gene, 40697 Neighboring gene Der1-like domain family, member 3

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC107654

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    dopachrome isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phenylpyruvate tautomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phenylpyruvate tautomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain renin-angiotensin system ISO
    Inferred from Sequence Orthology
    more info
     
    carboxylic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    drinking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell aging ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mature B cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of myeloid cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of acute inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of adaptive immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of arachidonic acid secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of axon regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine (C-X-C motif) ligand 2 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytokine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lipopolysaccharide-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of myeloid leukocyte cytokine production involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of prostaglandin secretion involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    macrophage migration inhibitory factor
    Names
    DER6
    L-dopachrome isomerase
    L-dopachrome tautomerase
    delayed early response protein 6
    glycosylation-inhibiting factor
    phenylpyruvate tautomerase
    NP_034928.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010798.2NP_034928.1  macrophage migration inhibitory factor

      See identical proteins and their annotated locations for NP_034928.1

      Status: PROVISIONAL

      Source sequence(s)
      AC142499
      Consensus CDS
      CCDS23934.1
      UniProtKB/Swiss-Prot
      P34884
      UniProtKB/TrEMBL
      Q545F0
      Related
      ENSMUSP00000041149.6, ENSMUST00000038169.7
      Conserved Domains (1) summary
      pfam01187
      Location:2115
      MIF; Macrophage migration inhibitory factor (MIF)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      75859353..75860250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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