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    MPZL1 myelin protein zero like 1 [ Homo sapiens (human) ]

    Gene ID: 9019, updated on 4-Jun-2017
    Official Symbol
    MPZL1provided by HGNC
    Official Full Name
    myelin protein zero like 1provided by HGNC
    Primary source
    HGNC:HGNC:7226
    See related
    Ensembl:ENSG00000197965 MIM:604376; Vega:OTTHUMG00000034571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PZR; PZRa; PZRb; PZR1b; MPZL1b
    Orthologs
    Location:
    1q24.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (167721950..167791919)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (167691187..167761156)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transfer RNA-Pro (CGG) 1-1 Neighboring gene transfer RNA-Pro (AGG) 2-1 Neighboring gene adenylate cyclase 10, soluble Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene DDB1 and CUL4 associated factor 6

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.
    NHGRI GWA Catalog
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ21047

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    myelin protein zero-like protein 1
    Names
    immunoglobulin family transmembrane protein
    protein zero related

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146191.1NP_001139663.1  myelin protein zero-like protein 1 isoform c precursor

      See identical proteins and their annotated locations for NP_001139663.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three alternate exons in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AK297112, AW292498, DA725074, Z99943
      Consensus CDS
      CCDS53425.1
      UniProtKB/Swiss-Prot
      O95297
      Related
      ENSP00000375968.3, OTTHUMP00000201770, ENST00000392121.7, OTTHUMT00000326411
      Conserved Domains (1) summary
      cl11960
      Location:3986
      Ig; Immunoglobulin domain
    2. NM_003953.5NP_003944.1  myelin protein zero-like protein 1 isoform a precursor

      See identical proteins and their annotated locations for NP_003944.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AW292498, AY359019, DA725074, Z99943
      Consensus CDS
      CCDS1264.1
      UniProtKB/Swiss-Prot
      O95297
      UniProtKB/TrEMBL
      A8K5D4
      Related
      ENSP00000352513.2, OTTHUMP00000032519, ENST00000359523.6, OTTHUMT00000083655
      Conserved Domains (2) summary
      cd05715
      Location:39154
      Ig_P0-like; Immunoglobulin (Ig)-like domain of Protein zero (P0) and similar proteins
      smart00410
      Location:43154
      IG_like; Immunoglobulin like
    3. NM_024569.4NP_078845.3  myelin protein zero-like protein 1 isoform b precursor

      See identical proteins and their annotated locations for NP_078845.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AF478447, AW292498, DA725074, Z99943
      Consensus CDS
      CCDS44273.1
      UniProtKB/Swiss-Prot
      O95297
      UniProtKB/TrEMBL
      A0A024R8Y3
      Related
      ENSP00000420455.1, OTTHUMP00000201812, ENST00000474859.5, OTTHUMT00000326467
      Conserved Domains (2) summary
      cd05715
      Location:39154
      Ig_P0-like; Immunoglobulin (Ig)-like domain of Protein zero (P0) and similar proteins
      smart00410
      Location:43154
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      167721950..167791919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      169113411..169183386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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